Email this article To the question of the pathogenesis of endometrial hyperplasia
- Authors: Bishtavi A.K.1, Gornikh O.A.1, Gulieva V.N.2, Chikovani N.G.2, Gogoladze K.T.2, Kostin A.Y.3, Ivanov A.Y.3, Chabrov A.M.3, Solopova A.G.2, Tabakman Y.Y.3, Manukhin I.B.1
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Affiliations:
- Department of Oncology, Moscow State University of Medicine and Dentistry
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
- Cancer Clinic No 1 Department of Health in Moscow
- Issue: No 3-4 (2012)
- Pages: 108-111
- Section: GYNECOLOGY. DIAGNOSIS
- Published: 24.09.2012
- URL: https://ojrs.abvpress.ru/ojrs/article/view/124
- DOI: https://doi.org/10.17650/1994-4098-2012-0-3-4-108-111
- ID: 124
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Abstract
Traditional attitude towards the role of hyperestrogenia in endometrial hyperplasia pathogenesis can be considered cogent only in case of simple endometrial hyperplasia (SEH). In case of complex endometrial hyperplasia (CEH) and atypical endometrial hyperplasia (AEH) excessive proliferation occurs only in endometrial glands not diffusely but as pockets. The signs of atrophy are often registered outside these pockets that reflects the state of estrogens.
The aim: is to study the structure of pathological endometrial changes that patients with abnormal uterine bleeding (AUB) have and natural combination of various forms of pathological endometrial changes.
Material. The results of histological examination of endometrium collected from 668 patients have been studied.
Results. The structure of pathological changes that occur in case of AUB has been identified. Various endometrial changes outside CEH and AEH pockets against the background of SEH, polyposis, atrophic endometrium have been detected without any regularity; the fact that does not confirm the role of hyperestrogenia in CEH and AEH pathogenesis.
Conclusion. SEH being the result of estrogen and progesterone imbalance is subjected to cyclic progestin hormone therapy to prevent acyclic bleeding. Observation with regular control is acceptable in the absence of AUB after the curettage in case of SEH and CEH without atypia. In case of AEH surgical treatment is required.
About the authors
A. Kh. Bishtavi
Department of Oncology, Moscow State University of Medicine and Dentistry
Author for correspondence.
Email: haled72@mail.ru
Russian Federation
O. A. Gornikh
Department of Oncology, Moscow State University of Medicine and DentistryRussian Federation
V. N. Gulieva
I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation
N. G. Chikovani
I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation
Kh. T. Gogoladze
I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation
A. Yu. Kostin
Cancer Clinic No 1 Department of Health in MoscowRussian Federation
A. Yе. Ivanov
Cancer Clinic No 1 Department of Health in MoscowRussian Federation
A. M. Chabrov
Cancer Clinic No 1 Department of Health in MoscowRussian Federation
A. G. Solopova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian Federation
Yu. Yu. Tabakman
Cancer Clinic No 1 Department of Health in MoscowRussian Federation
I. B. Manukhin
Department of Oncology, Moscow State University of Medicine and DentistryRussian Federation
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