Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press104210.17650/1994-4098-2022-18-4-127-137GYNECOLOGY. REVIEWSГИНЕКОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИMalignant endometriosis-associated ovarian and extraovarian neoplasia (review of literature)Малигнизированные эндометриоз-ассоциированные овариальные и экстраовариальные неоплазии: обзор литературыhttps://orcid.org/0000-0002-0486-2404KotivKh. B.КотивХ. Б.
Russian Federation

Khristina B. Kotiv.

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

Котив Христина Богдановна.

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015 Санкт-Петербург, ул. Кирочная, 41

kotiv.onc@gmail.comhttps://orcid.org/0000-0003-1719-7498GorodnovaT. V.ГородноваТ. В.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0002-1886-3993LavrinovichO. E.ЛавриновичО. Е.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0001-6937-2740BerlevI. V.БерлевИ. В.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015 Санкт-Петербург, ул. Кирочная, 41

N.N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России0312202218412713703082022300420232022https://ojrs.abvpress.ru/ojrs/article/view/1042

Malignant transformation of endometrioid heterotopias develops in 0.7-2.5 % of cases; 75 % of cases have an ovarian localisation and 25 % an extraovarian one. As it has been suggested that malignant endometriosis-associated neoplasia (MEAN) is developed in foci of atypical endometriosis. The review describes the mechanisms of carcinogenesis, the clinical and morphological features of the disease, and the principles of therapy. MEAN usually occur in younger women, are detected at stages I-II, and are mostly represented by clear cell and endometrioid carcinomas, but rare histological types have also been described. CTNNB1, PTEN, PIK3CA and ARID1A mutations are often detected in MEAN. The treatment of MEAN is not standardised, there are no prospective randomized trials assessing treatment. Patients with ovarian MEAN receive therapy similar to epithelial ovarian cancer. Patients with extraovarian localisation represent a subgroup that of patients that may require a personalised approach.

Злокачественная трансформация эндометриоидных гетеротопий развивается в 0,7-2,5 % случаев, из которых 75 % имеют овариальную локализацию, 25 % - экстраовариальную. Существует гипотеза о формировании малигнизированных эндометриоз-ассоциированных неоплазий (МЭАН) в очагах атипичного эндометриоза. В обзоре описаны механизмы канцерогенеза, клинико-морфологические особенности заболевания и принципы терапии. МЭАН обычно развиваются у молодых женщин, диагностируются на I-II стадии, в большинстве случаев представлены светлоклеточными и эндометриоидными карциномами, но также описаны редкие гистологические типы. мутации в генах CTNNB1, PTEN, PIK3CA и ARID1A часто выявляют при МЭАН. лечение МЭАН не стандартизовано, отсутствуют проспективные рандомизированные исследования. Пациентки с овариальной локализацией МЭАН получают терапию, соответствующую стандартам лечения рака яичников. больные с экстраовариальной локализацией представляют особую подгруппу пациенток, которым требуется персонализированный подход.

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