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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1047</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2022-18-4-26-31</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Organ-sparing treatment for breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Органосохраняющее лечение при раке молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rasskazova</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Рассказова</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Elena A. Rasskazova.</p><p>3 2<sup>nd</sup> Botkinskiy Proezd, Moscow 125284</p></bio><bio xml:lang="ru"><p>Рассказова Елена Александровна.</p><p>125284 Москва, 2-й Боткинский проезд, 3</p></bio><email>rasskaz2@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7141-2502</contrib-id><name-alternatives><name xml:lang="en"><surname>Zikiryakhodzhaev</surname><given-names>A. D.</given-names></name><name xml:lang="ru"><surname>Зикиряходжаев</surname><given-names>А. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 2<sup>nd</sup> Botkinskiy Proezd, Moscow 125284; Build. 2, 8 Trubetskaya St., Moscow 119991; 6 Miklukho-Maklaya St., Moscow 117198</p></bio><bio xml:lang="ru"><p>125284 Москва, 2-й Боткинский проезд, 3; 119991 Москва, ул. Трубецкая, 8, стр. 2; 117198 Москва, ул. Миклухо-Маклая, 6</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name><name xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 2<sup>nd</sup> Botkinskiy Proezd, Moscow 125284; 6 Miklukho-Maklaya St., Moscow 117198</p></bio><bio xml:lang="ru"><p>125284 Москва, 2-й Боткинский проезд, 3; 117198 Москва, ул. Миклухо-Маклая, 6</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">P.A. Herzen Moscow Oncology Research Institute — a branch of the National Medical Radiology Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена — филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Peoples' Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-03" publication-format="electronic"><day>03</day><month>12</month><year>2022</year></pub-date><volume>18</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>26</fpage><lpage>31</lpage><history><date date-type="received" iso-8601-date="2020-09-11"><day>11</day><month>09</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2023-05-01"><day>01</day><month>05</month><year>2023</year></date></history><permissions><copyright-year>2022</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/1047">https://ojrs.abvpress.ru/ojrs/article/view/1047</self-uri><abstract xml:lang="en"><p>This article reviews literature on organ-sparing and oncoplastic surgeries for breast cancer. Initially, we performed organ-sparing surgeries in patients with stage I—IIA breast cancer and then compared outcomes with those in patients after radical mastectomy. Since there were no differences in both overall and relapse-free survival between the groups, we started to perform organ-sparing surgeries in women with locally advanced breast cancer after neoadjuvant therapy who achieved complete or partial response. Oncoplastic resections were used to achieve good aesthetic results and also for patients in whom classical organ-sparing resection would inevitably result in a poor cosmetic outcome due to the tumor location. In recent years, the technique of extreme oncoplastic breast resection has emerged as a promising option that extended the scope of indications to organ-sparing treatment. In particular, it allows breast conservation for patients with multicentric, multifocal tumors, and tumors &gt;50 mm. All organ-sparing and oncoplastic operations first of all improve the quality of life of breast cancer patients. </p></abstract><trans-abstract xml:lang="ru"><p>В статье представлены данные литературы об органосохраняющих и онкопластических резекциях молочной железы при раке молочной железы (РМЖ). Изначально органосохраняющие операции выполняли у пациенток с I—IIA стадией, сравнивая результаты лечения с результатами пациенток после радикальных мастэктомий. так как не было значимых различий в безрецидивной и общей выживаемости в обеих группах, выполнять органосохраняющие операции стали и у больных местно-распространенным РмЖ после неоадъювантной лекарственной терапии и достижения полного или частичного регресса опухолевого узла. Онкопластические резекции стали применять для достижения хороших эстетических результатов при РМЖ, а также при такой локализации опухолевого узла в молочной железе, которая заведомо приведет к неудовлетворительным косметическим результатам при классической органосохраняющей резекции. В последние годы появилось понятие экстремальной онкопластической резекции молочной железы, при которой показания к выполнению органосохраняющего лечения расширены, а именно оно показано при мультицентричном, мультифокальном росте и размере опухолевого узла &gt;50 мм. Все органосохраняющие и онкопластические операции повышают, прежде всего, качество жизни пациенток с РМЖ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>organ-sparing surgeries</kwd><kwd>oncoplastic surgeries</kwd><kwd>extreme oncoplastic surgeries</kwd><kwd>recurrent breast cancer</kwd><kwd>breast cancer resection margin</kwd><kwd>R1</kwd><kwd>rehabilitation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>органосохраняющие операции</kwd><kwd>онкопластические операции</kwd><kwd>экстремальные онкопластические операции</kwd><kwd>рецидив рака молочной железы</kwd><kwd>края резекции молочной железы</kwd><kwd>R1</kwd><kwd>реабилитация</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Situation with cancer care in Russia in 2019. Ed. by A.D. Kaprin, V.V. Starinskiy, A.O. Shakhzadova. Moscow: P.A. 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