Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press10810.17650/1994-4098-2012-0-3-4-10-12MAMMOLOGY. TOPICAL ISSUEМАММОЛОГИЯ. АКТУАЛЬНАЯ ТЕМАIncreasing the radicalism of organ-saving surgery for breast cancer by an intraoperative histological studyПовышение радикализма органосохраняющих операций при раке молочной железы путем проведения интраоперационного гистологического исследованияPortnoyS. M.ПортнойС. М.
Russian Federation
sportnoj@yahoo.comAnurovaO. A.АнуроваО. А.
Russian Federation
KorotkikhI. Yu.КороткихИ. Ю.
Russian Federation
PortyankoN. M.ПортянкоН. М.
Russian Federation
LaktionovK. P.ЛактионовК. П.
Russian Federation
MaslyaevA. V.МасляевА. В.
Russian Federation
KuznetsovA. V.КузнецовА. В.
Russian Federation
RepetyukD. V.РепетюкД. В.
Russian Federation
IvanovS. M.ИвановС. М.
Russian Federation
KarpovA. V.КарповА. В.
Russian Federation
N.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical Sciences, MoscowФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва240920123-4101224072014240720142012https://ojrs.abvpress.ru/ojrs/article/view/108

The paper gives the long-term results of organ-saving surgery in 141 patients with stage Ia–IIIc breast cancer. Emergent histological examina- tion of a breast tissue sector was made during the surgery. Due to intraoperative morphological findings, the surgical volume was extended to gland reresection or mastectomy in 34 % of cases. There were low rates of local recurrences (0.6 % per year) and delayed operations.

Представлены отдаленные результаты органосохраняющих операций больных раком молочной железы Ia−IIIc стадии (n = 141). Во время операции выполнялось срочное гистологическое исследование сектора ткани молочной железы. В 34 % случаев вследствие интраоперационных морфологических находок объем операции был расширен до ререзекции железы или мастэктомии. Отмечена низкая частота местных рецидивов (0,6 % в год) и невысокая частота отсроченных операций.

histological studyradical mastectomylumpectomyorgan-saving surgeryintraoperative histological studyгистологическое исследованиерадикальная мастэктомиялампэктомияорганосохраняющие операцииинтраоперационное гистологическое исследование1. Rutgers E.J. Th. for the EUSOMA Consensus Group. Quality control in the locoregional treatment of breast cancer. Eur J Cancer 2001;37:447−53.Rutgers E.J. Th. for the EUSOMA Consensus Group. Quality control in the locoregional treatment of breast cancer. Eur J Cancer 2001;37:447−53.2. Вишнякова В.В. О возможности уменьшения объема оперативного вмешательства в радикальном лечении рака молочной железы. Вестник АМН СССР 1976;2:57−61.Вишнякова В.В. О возможности уменьшения объема оперативного вмешательства в радикальном лечении рака молочной железы. Вестник АМН СССР 1976;2:57−61.3. Veronesi U., Saccozzi R., Del V.M. et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 1981;305:6−11.Veronesi U., Saccozzi R., Del V.M. et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 1981;305:6−11.4. Fisher B., Bauer M., Margolese R. et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 1985;312:665−73.Fisher B., Bauer M., Margolese R. et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 1985;312:665−73.5. Блохин С.Н., Портной С.М. Способ хирургического лечения рака молочной железы по С.Н. Блохину и С.М. Портному. Патент РФ No 2092112. Зарегистрирован 10.10.1997. Приоритет с 7.10.93.Блохин С.Н., Портной С.М. Способ хирургического лечения рака молочной железы по С.Н. Блохину и С.М. Портному. Патент РФ No 2092112. Зарегистрирован 10.10.1997. Приоритет с 7.10.93.6. Portnoj S.M., Blokhin S.N., Lactionov K.P. et al. May be, the best breast conserving operation (BCO). XVIth Int Cancer Congr. New Delhi, 1994, PSBR 2−12.Portnoj S.M., Blokhin S.N., Lactionov K.P. et al. May be, the best breast conserving operation (BCO). XVIth Int Cancer Congr. New Delhi, 1994, PSBR 2−12.7. Fisher B., Anderson S., Fisher E. et al. Significance of ipsilateral breast tumour recurrence after lumpectomy. The Lancet 1991;338(8763):327−31.Fisher B., Anderson S., Fisher E. et al. Significance of ipsilateral breast tumour recurrence after lumpectomy. The Lancet 1991;338(8763):327−31.8. Leong C., Boyages J., Jayasinghe U.W. et al. Effect of margins on ipsilateral breast tumor recurrence after breast conservation therapy for lymph node-negative breast carcinoma. Cancer 2004;100(9):1823−32.Leong C., Boyages J., Jayasinghe U.W. et al. Effect of margins on ipsilateral breast tumor recurrence after breast conservation therapy for lymph node-negative breast carcinoma. Cancer 2004;100(9):1823−32.9. Meric F., Mirza N.Q., Vlastos G. et al. Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy. Cancer 2003;97(4):926−33.Meric F., Mirza N.Q., Vlastos G. et al. Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy. Cancer 2003;97(4):926−33.10. Kaufmann M., Morrow M., von Minckwitz G., Harris J.R. Locoregional treatment of primary breast cancer. Cancer 2010;116:1184−91.Kaufmann M., Morrow M., von Minckwitz G., Harris J.R. Locoregional treatment of primary breast cancer. Cancer 2010;116:1184−91.11. Mirza N.Q., Vlastos G., Meric F. et al. Predictors of Locoregional Recurrence Among Patients With Early-Stage Breast Cancer Treated With Breast-Conserving Therapy. Ann Surg Oncol 2002;9:256−65.Mirza N.Q., Vlastos G., Meric F. et al. Predictors of Locoregional Recurrence Among Patients With Early-Stage Breast Cancer Treated With Breast-Conserving Therapy. Ann Surg Oncol 2002;9:256−65.12. Olson T.P., Harter J., Muñoz A. et al. Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local re- currence. Ann Surg Oncol 2007;14(10):2953−60.Olson T.P., Harter J., Muñoz A. et al. Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local re- currence. Ann Surg Oncol 2007;14(10):2953−60.13. Cabioglu N., Hunt K.K., Sahin A.A. et al. Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 2007;14(4):1458−71.Cabioglu N., Hunt K.K., Sahin A.A. et al. Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 2007;14(4):1458−71.