Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press11010.17650/1994-4098-2012-0-3-4-19-28MAMMOLOGY. TOPICAL ISSUEМАММОЛОГИЯ. АКТУАЛЬНАЯ ТЕМАAnalysis of proteins associated with the expression of cyclooxygenase-2 and the biosynthesis of PGE2 in breast cancer cells with different metastatic potentialАнализ белков, ассоциированных с экспрессией циклооксигеназы-2 и биосинтезом PGE2 в клетках рака молочной железы с разным метастатическим потенциаломShevchenkoV. E.ШевченкоВ. Е.
Russian Federation
TaipovM. A.ТаиповМ. А.
Russian Federation
taipoff.m@yandex.ruKovalevS. V.КовалевС. В.
Russian Federation
ArnotskayaN. E.АрноцкаяН. Е.
Russian Federation
PavlovaO. M.ПавловаО. М.
Russian Federation
KudryavtsevI. A.КудрявцевИ. А.
Russian Federation
NikiforovaZ. N.НикифороваЗ. Н.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва240920123-4192824072014240720142012https://ojrs.abvpress.ru/ojrs/article/view/110

The proteome of lysates of the breast tumor cell lines MCF-7, BT-474, and ZR-75-1 was mapped, resulting in the sequence of 340 proteins. The proteins associated with the biosynthesis of PGE2 and with the regulation of cyclooxygenase-2 expression were identified and their relative expression levels were determined. Potential goals for the targeted therapy of breast cancer, such as prostaglandin E2 and D2 receptors, pros- taglandin E synthase, 15-hydroxyprostaglandin dehydrogenase and leukotriene-A4 -hydrolase, are of special interest in this group.

Проведено картирование протеома лизатов линий опухолевых клеток молочной железы MCF-7, BT-474, ZR-75-1, в результате секвенировано 340 белков. Идентифицированы белки, ассоциированные с биосинтезом PGE2 и регуляцией экспрессии циклоокси- геназы-2, и определены их относительные уровни экспрессии. В данной группе особый интерес представляют потенциальные мишени для направленной терапии рака молочной железы: рецепторы простагландинов E2 , D2 , простагландин Е-синтаза, 15-гид- рокси-простагландиндегидрогеназа и лейкотриен-А4-гидролаза.

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