Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press11810.17650/1994-4098-2012-0-3-4-73-83MAMMOLOGY. TREATMENTМАММОЛОГИЯ. ЛЕЧЕНИЕIntensified dose-dense neoadjuvant chemotherapy using paclitaxel-gemcitabine and docetaxel-doxorubicin combinations for locally advanced breast cancerИнтенсифицированная неоадъювантная химиотерапия в уплотненном режиме с использованием комбинаций паклитаксела с гемцитабином и доцетаксела с доксорубицином при местно-распространенном раке молочной железыFraiI. V.ФрайИ. В.
Russian Federation
inessa_frey@mail.ruGorbunovaV. A.ГорбуноваВ. А.
Russian Federation
PerevodchikovaN. I.ПереводчиковаН. И.
Russian Federation
LetyaginV. P.ЛетягинВ. П.
Russian Federation
AnurovaO. A.АнуроваО. А.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБУ «РОНЦ им. Н.Н. Блохина РАМН», Москва240920123-47383240720142012https://ojrs.abvpress.ru/ojrs/article/view/118

The developed chemotherapy (CT) regimen with paclitaxel and gemcitabine with the interval being reduced between the cycles up to 2 weeks can shorten the time of preoperative treatment 1.5-fold and may be further investigated in the neoadjuvant CT for inoperable breast cancer. Intensified CT in the regimen of paclitaxel 175 mg/m2 one day, gemcitabine 2000 mg/m2 one day, docetaxel 70 mg/m2 one day + doxorubi- cin 60 mg/m2 one day + colony-stimulating factors every 2 weeks has a high clinical effectiveness and a satisfactory tolerability.

Разработанный режим химиотерапии (ХТ) паклитакселом и гемцитабином с сокращением интервала между циклами до 2 нед позволяет в 1,5 раза сократить сроки проведения предоперационного лечения и может быть изучен далее в неоадъювантной ХТ операбельного рака молочной железы. Интенсифицированная ХТ в режиме паклитаксел 175 мг/м2 1-й день + гемцитабин 2000 мг/м2 1-й день, доцетаксел 70 мг/м2 1-й день + доксорубицин 60 мг/м2 1-й день + колониестимулирующий фактор каждые 2 нед обладает высокой клинической эффективностью и удовлетворительной переносимостью.

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