Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press121110.17650/1994-4098-2024-20-1-89-103MAMMOLOGY. REVIEWSМАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИEscalation of adjuvant endocrine therapy for early hormone-dependent HER2-negative breast cancer: to whom, when and why?Эскалация адъювантной эндокринотерапии раннего гормонозависимого HER2-отрицательного рака молочной железы: кому, когда и зачем?https://orcid.org/0000-0002-1124-6802KolyadinaI. V.КолядинаИ. В.
Russian Federation

Irina Vladimirovna Kolyadina  

2/1 Barrikadnaya St., Moscow 125993, Russia;

4 Akademika Oparina St., Moscow 117198, Russia 

Ирина Владимировна Колядина  

Россия, 125993 Москва, ул. Баррикадная, 2/1, стр. 1;

Россия, 117997 Москва, ул. Академика Опарина, 4 

irinakolyadina@yandex.comRussian Medical Academy of Continuous Professional Education, Ministry of Health of RussiaФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииV.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России19052024201891030804202417052024https://ojrs.abvpress.ru/ojrs/article/view/1211

This review presents the evolution of adjuvant endocrine therapy for early hormone-dependent HER2-negative breast cancer, describes late relapse phenomenon, provides clinical rationale for escalation of treatment, analyzes the key stages of the metastatic cascade, and provides a scientific rationale for the introduction of CDK4/6 inhibitors into adjuvant treatment regimens. The main results of two large randomized studies of therapy including abemaciclib (MonarchE) and ribociclib (NATALEE) in patients with early stages of hormone-dependent HER2-negative breast cancer are presented; the oncological results of escalation of treatment and the safety of therapy are assessed.

В настоящем обзоре представлена эволюция адъювантной эндокринотерапии раннего гормонозависимого HER2-отрицательного рака молочной железы, описан феномен позднего рецидивирования и дано клиническое обоснование для проведения эскалации лечения, проанализированы ключевые этапы метастатического каскада и дано научное обоснование внедрения ингибиторов CDK4/6 в адъювантные режимы терапии. Представлены основные результаты 2 крупных рандомизированных исследований терапии с включением абемациклиба (MonarchE) и рибоциклиба (NATALEE) у больных с ранними стадиями гормонозависимого HER2-отрицательного рака молочной железы, оценены онкологические результаты эскалации лечения и безопасность терапии.

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