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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1241</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2024-16-2-99-104</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Analysis of the incidence of uterine fibroid in Yekaterinburg</article-title><trans-title-group xml:lang="ru"><trans-title>Анализ заболеваемости лейомиомой матки в г. Екатеринбурге</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0828-0479</contrib-id><name-alternatives><name xml:lang="en"><surname>Sevostyanova</surname><given-names>O. Yu.</given-names></name><name xml:lang="ru"><surname>Севостьянова</surname><given-names>О. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Olga Yuryevna Sevostyanova</p><p>3 Repina St., Yekaterinburg 620028</p></bio><bio xml:lang="ru"><p>Ольга Юрьевна Севостьянова</p><p>20028 Екатеринбург, ул. Репина, 3</p></bio><email>olsyava@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1321-6583</contrib-id><name-alternatives><name xml:lang="en"><surname>Koval</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Коваль</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 Repina St., Yekaterinburg 620028</p></bio><bio xml:lang="ru"><p>620028 Екатеринбург, ул. Репина, 3</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7965-2364</contrib-id><name-alternatives><name xml:lang="en"><surname>Chumarnaya</surname><given-names>T. V.</given-names></name><name xml:lang="ru"><surname>Чумарная</surname><given-names>Т. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>106 Pervomayskaya St., Yekaterinburg 620078</p></bio><bio xml:lang="ru"><p>620078 Екатеринбург, ул. Первомайская, 106</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4031-4907</contrib-id><name-alternatives><name xml:lang="en"><surname>Belomestnov</surname><given-names>S. R.</given-names></name><name xml:lang="ru"><surname>Беломестнов</surname><given-names>С. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 Repina St., Yekaterinburg 620028</p></bio><bio xml:lang="ru"><p>620028 Екатеринбург, ул. Репина, 3</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0237-6645</contrib-id><name-alternatives><name xml:lang="en"><surname>Sevostyanova</surname><given-names>N. E.</given-names></name><name xml:lang="ru"><surname>Севостьянова</surname><given-names>Н. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p> 10 Soboleva St., Yekaterinburg 620036</p></bio><bio xml:lang="ru"><p>620036 Екатеринбург, ул. Соболева, 10</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Oboskalova</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Обоскалова</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 Repina St., Yekaterinburg 620028</p></bio><bio xml:lang="ru"><p>620028 Екатеринбург, ул. Репина, 3</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-5995-117X</contrib-id><name-alternatives><name xml:lang="en"><surname>Striganova</surname><given-names>O. D.</given-names></name><name xml:lang="ru"><surname>Стриганова</surname><given-names>О. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>3 Repina St., Yekaterinburg 620028</p></bio><bio xml:lang="ru"><p>620028 Екатеринбург, ул. Репина, 3</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ural State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФБОУ ВО «Уральский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science</institution></aff><aff><institution xml:lang="ru">ФГБУН «Институт иммунологии и физиологии УрО РАН»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Military Clinical Hospital of the National Guard of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФКГУЗ «5 военный клинический госпиталь войск национальной гвардии Российской Федерации»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-07-29" publication-format="electronic"><day>29</day><month>07</month><year>2024</year></pub-date><volume>20</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>99</fpage><lpage>104</lpage><history><date date-type="received" iso-8601-date="2024-07-29"><day>29</day><month>07</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-07-29"><day>29</day><month>07</month><year>2024</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/1241">https://ojrs.abvpress.ru/ojrs/article/view/1241</self-uri><abstract xml:lang="en"><p><bold>Background.</bold> Uterine fibroid (UF) is a benign tumor of the myometrium and is considered as one of the criteria for the state of women’s reproductive health. Objective information about the incidence of UF in a modern megalopolis allows us to assess the level of health of the female population, characterize the availability and quality of medical care, and plan its development.</p><p><bold>Aim.</bold> To analyze the incidence and prevalence of UF according to the data of medical organizations in Yekaterinburg in 2016–2022.</p><p><bold>Materials and methods.</bold> An epidemiological study of the incidence and prevalence of the adult female population of the city of Yekaterinburg in 2016–2022 was conducted. For the analysis, we used Form No. 12 of the Federal Statistical Observation of Medical Organizations located in the city. The incidence rates were calculated for the average annual female population aged 18 years and over, expressed in <sup>0</sup>/<sub>0000</sub>. Absolute growth (decrease), growth rate (decrease), growth rate (decrease), average growth rate (decrease) were studied. The long-term dynamics of the indicators was determined using the average growth rate.</p><p><bold>Results.</bold> The incidence of UF was 130.89<sup>0</sup>/<sub>0000</sub>, and the prevalence was 735.80<sup>0</sup>/<sub>0000</sub> in 2016. During the pre-pandemic period, the indicators increased significantly in 2019 compared to the baseline year 2016 (<italic>р</italic> &lt; 0.001). The incidence increased by 1.96 times, the prevalence – by 1.39 times. The indicators decreased to the level of 2016 during the pandemic of new coronavirus infection (2020–2022) (<italic>р</italic> &gt;0.05).</p><p><bold>Conclusion.</bold> The obtained dynamics of incidence and prevalence of UF in the population of women in a modern megalopolis is considered as a criterion for the state of women’s health, accessibility and quality of preventive and planned medical care for gynecological patients. The results of the study are recommended for planning medical care for women and can form the basis for continuing epidemiological studies.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение.</bold> Лейомиома матки (ЛМ) является доброкачественной опухолью миометрия и рассматривается в качестве одного из критериев состояния репродуктивного здоровья женщин. Объективная информация о заболеваемости ЛМ в современном мегаполисе позволяет оценить уровень репродуктивного здоровья популяции женского населения, охарактеризовать доступность и качество медицинской помощи, планировать ее развитие.</p><p><bold>Цель исследования</bold> – провести анализ первичной (ПЗ) и общей заболеваемости (ОЗ) ЛМ по данным медицинских организаций г. Екатеринбурга в 2016–2022 гг.</p><p><bold>Материалы и методы.</bold> Проведено эпидемиологическое исследование ПЗ и ОЗ ЛМ взрослого женского населения г. Екатеринбурга в 2016–2022 гг. Для анализа использовали форму федерального статистического наблюдения №12 медицинских организаций, расположенных на территории города. Показатели заболеваемости рассчитывали на среднегодовую численность женского населения в возрасте 18 лет и старше, выражали в <sup>0</sup>/<sub>0000</sub>. Исследовали абсолютный прирост (убыль), темп роста (снижения), темп прироста (снижения), средний темп прироста (снижения). Многолетнюю динамику показателей определяли с помощью среднего темпа прироста.</p><p><bold>Результаты.</bold> ПЗ ЛМ составила 130,89<sup>0</sup>/<sub>0000</sub>, ОЗ – 735,80<sup>0</sup>/<sub>0000</sub> в 2016 г. В течение допандемийного периода показатели значимо увеличились в 2019 г. по сравнению с исходным 2016 г. (<italic>р</italic> &lt;0,001): ПЗ возросла в 1,96 раза, ОЗ – в 1,39 раза. Показатели уменьшились до уровня 2016 г. во время пандемии новой коронавирусной инфекции (2020–2022 гг.) (<italic>р</italic> &gt;0,05).</p><p><bold>Выводы.</bold> Динамика ПЗ и ОЗ ЛМ в популяции женщин современного мегаполиса рассматривается как критерий состояния здоровья женщин, доступности и качества профилактической и плановой медицинской помощи пациенткам гинекологического профиля. Результаты исследования рекомендуются для планирования медицинской помощи женщинам и могут составить основу для продолжения эпидемиологических исследований.</p></trans-abstract><kwd-group xml:lang="en"><kwd>incidence</kwd><kwd>prevalence</kwd><kwd>uterine fibroid</kwd><kwd>uterus</kwd><kwd>Yekaterinburg</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>первичная заболеваемость</kwd><kwd>общая заболеваемость</kwd><kwd>лейомиома</kwd><kwd>матка</kwd><kwd>Екатеринбург</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The study was performed without external funding.</funding-statement><funding-statement xml:lang="ru">Исследование проведено без спонсорской поддержки.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Uterine fibroids. Clinical recommendations. Moscow, 2022. 35 p. Available at: https://roag-portal.ru/recommendations_gynecology. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Миома матки. Клинические рекомендации. М., 2022. 35 с. Доступно по: https://roag-portal.ru/recommendations_gynecology.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">International Classification of Diseases 10th revision (ICD-10). Available at: https://mkb-10.com/. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Международная классификация болезней 10-го пересмотра (МКБ-10). Доступно по: https://mkb-10.com/.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>Machado-Lopez A., Simón C., Mas A. Molecular and cellular insights into the development of uterine fibroids. Int J Mol Sci 2021;22(16):8483. DOI: 10.3390/ijms22168483</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Langton C.R., Gerety M., Harmon Q.E. et al. Keloids, hypertrophic scars, and uterine fibroid development: A prospective ultrasound study of black and African American women. F S Sci 2023;4(2):172–80. DOI: 10.1016/j.xfss.2023.03.006</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Roberts M.E., Aynardi J.T., Chu C.S. Uterine leiomyosarcoma: A review of the literature and update on management options. Gynecol Oncol 2018;151(3):562–72. DOI: 10.1016/j.ygyno.2018.09.010</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ricci G., Scrimin F., Sartore A et al. Characteristics of submucous myomas and the risk of anemia. Medicina (Kaunas) 2022;58(11):1652. DOI: 10.3390/medicina58111652</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Navarro A., Bariani M.V., Yang Q., Al-Hendy A. Understanding the impact of uterine fibroids on human endometrium function. Front Cell Dev Biol 2021;9:633180. DOI: 10.3389/fcell.2021.633180</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Pérez-Roncero G.R., López-Baena M.T., Ornat L. et al. Uterine fibroids and preterm birth risk: A systematic review and metaanalysis. J Obstet Gynaecol Res 2020;46(9):1711–27. DOI: 10.1111/jog.14343</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Yu O., Scholes D., Schulze-Rath R. et al. A US population-based study of uterine fibroid diagnosis incidence, trends, and prevalence: 2005 through 2014. Am J Obstet Gynecol 2018;219(6):591.e1–8. DOI: 10.1016/j.ajog.2018.09.039</mixed-citation></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Sadykhova E.E., Bezhenar V.F., Arakelyan B.V. et al. Opportunities for the use of X-ray endosurgical hemostasis in complex treatment of uterine myoma in patients with severe anemia. Uralskiy meditsinskiy zhurnal = Ural Medical Journal 2019;3(171):59–63. (In Russ.). DOI: 10.25694/URMJ.2019.03.23</mixed-citation><mixed-citation xml:lang="ru">Садыхова Э.Э., Беженарь В.Ф., Аракелян Б.В. и др. Возможности применения рентгеноэндохирургического гемостаза в комплексной терапии миомы матки у пациенток с тяжелой анемией. Уральский медицинский журнал 2019;3(171):59–63. DOI: 10.25694/URMJ.2019.03.23</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Podzolkova N.M., Korennaya V.V., Koloda Yu.A. et al. Functional outcomes of myomectomy. Problemy reproduktsii = Russian Journal of Human Reproduction 2020;26(3):31–8. (In Russ.). DOI: 10.17116/repro20202603131</mixed-citation><mixed-citation xml:lang="ru">Подзолкова Н.М., Коренная В.В., Колода Ю.А. и др. Функциональные исходы миомэктомии. Проблемы репродукции 2020;26(3):31–8. DOI: 10.17116/repro20202603131</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><mixed-citation>Marsh E.E., Al-Hendy A., Kappus D. et al. Prevalence, and treatment of uterine fibroids: A survey of U.S. women. J Womens Health (Larchmt) 2018;27(11):1359–67. DOI: 10.1089/jwh.2018.7076</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Hartmann K.E., Fonnesbeck C., Surawicz T. et al. Management of uterine fibroids. AHRQ comparative efectiveness review. Rockville, 2017. Available at: https://efectivehealthcare.ahrq.gov/sites/default/fles/pdf/cer-195-uterine-fbroids-fnal-revision.pdf.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Cheng L.C., Li H.Y., Gong Q.Q. et al. Global, regional, and national burden of uterine fibroids in the last 30 years: Estimates from the 1990 to 2019 Global Burden of Disease Study. Front Med (Lausanne) 2022;9:1003605. DOI: 10.3389/fmed.2022.1003605</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Harris H.R., Petrick J.L., Rosenberg L. The epidemiology of uterine fibroids: Where do we go from here? Fertil Steril 2022;117(4):841, 842. DOI: 10.1016/j.fertnstert.2022.01.037</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Wise L.A., Laughlin-Tommaso S.K. Epidemiology of uterine fibroids: From menarche to menopause. Clin Obstet Gynecol 2016;59(1):2–24. DOI: 10.1097/GRF.0000000000000164</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Sung H., Siegel R.L., Torre L.A. et al. Global patterns in excess body weight and the associated cancer burden. CA Cancer J Clin 2019;69(2):88–112. DOI: 10.3322/caac.21499</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Takala H., Yang Q., El Razek A.M.A. et al. Alcohol consumption and risk of uterine fibroids. Curr Mol Med 2020;20(4):247–58. DOI: 10.2174/1566524019666191014170912</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Morhason-Bello I.O., Adebamowo C.A. Epidemiology of uterine fibroid in black African women: A systematic scoping review. BMJ Open 2022;12:e052053. DOI: 10.1136/bmjopen-2021-052053</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Carey C.M., Katon J., Bossick A. et al. Uterine weight as a modifier of black/white racial disparities in minimally invasive hysterectomy among veterans with fibroids in the Veterans Health Administration. Health Equity 2022;6(1):909–16. Available at: https://www.liebertpub.com/doi/abs/10.1089/heq.2022.0130.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Ngorili G.S., Yadav B.B., Takalkar A.A. Epidemiological study of uterine fibroids: Our experience from urban Maharashtra. Int J Reprod Contracept Obstet Gynecol 2022;11:2101–5. DOI: 10.18203/2320-1770.ijrcog20221918</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Leyland N., Leonardi M., Murji A. et al. A call-to-action for clinicians to implement evidence-based best practices when caring for women with uterine fibroids. Reprod Sci 2022;29:1188–96. DOI: 10.1007/s43032-022-00877-3</mixed-citation></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Leonov S.A., Son I.M., Savina A.A. Guidelines for the analysis of the main statistical indicators of the health status of the population and the activities of medical organizations. Moscow, 2015. 53 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Леонов С.А., Сон И.М., Савина А.А. Руководство по анализу основных статистических показателей состояния здоровья населения и деятельности медицинских организаций. М., 2015. 53 с.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Federal State Statistics Service. Order No. 409 dated November 22, 2010 “On the approval of the Practical Manual on Health Statistics”. Moscow, 2010. 102 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Федеральная служба государственной статистики. Приказ от 22 ноября 2010 г. № 409 «Об утверждении практического пособия по статистике здравоохранения». М., 2010. 102 с.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Kucherenko V.Z., Avksentieva M.V., Alekseeva V.M. et al. Application of statistical analysis methods for the study of public health and healthcare: A textbook. Moscow: GEOTAR-Media, 2011. 256 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Кучеренко В.З., Авксентьева М.В., Алексеева В.М. и др. Применение методов статистического анализа для изучения общественного здоровья и здравоохранения: учебное пособие. М.: ГЭОТАР-Медиа, 2011. 256 с.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">Slobodenyuk A.V., Kosova A.A., An R.N. Epidemiological analysis: A textbook. Yekaterinburg, 2015. 36 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Слободенюк А.В., Косова А.А., Ан Р.Н. Эпидемиологический анализ: учебное пособие. Екатеринбург, 2015. 36 с.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">Rebrova O.Yu. Statistical analysis of medical data. Application of the STATISTICA application software package. Мoscow: MediaSfera, 2006. 305 р. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М.: МедиаСфера, 2006. 305 с.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
