Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press131910.17650/1994-4098-2024-20-4-70-80MAMMOLOGY. REVIEWSМАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИProgesterone and progesterone receptors in breast cancer: past, present, and futureПрогестерон и прогестероновые рецепторы при раке молочной железы: прошлое, настоящее, будущееhttps://orcid.org/0000-0002-0658-1454RodionovaM. V.РодионоваМ. В.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

 Россия, 117997 Москва, ул. Академика Опарина, 4 

https://orcid.org/0000-0003-0096-7126RodionovV. V.РодионовВ. В.
Russian Federation

Valeriy Vitalyevich Rodionov 

4 Akademika Oparina St., Moscow 117198, Russia

Валерий Витальевич Родионов  

Россия, 117997 Москва, ул. Академика Опарина, 4 

dr.valery.rodionov@gmail.comhttps://orcid.org/0000-0001-9666-6875KometovaV. V.КометоваВ. В.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

 Россия, 117997 Москва, ул. Академика Опарина, 4 

https://orcid.org/0000-0002-0627-3902SmetnikA. A.СметникА. А.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

 Россия, 117997 Москва, ул. Академика Опарина, 4 

https://orcid.org/0000-0002-1124-6802KolyadinaI. V.КолядинаИ. В.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

Build. 1, 2/1 Barrikadnaya St., Moscow 125993, Russia

Россия, 117997 Москва, ул. Академика Опарина, 4 

Россия, 125993 Москва, ул. Баррикадная, 2/1, стр. 1

https://orcid.org/0000-0003-2842-3980BurmenskayaO. V.БурменскаяО. В.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

 Россия, 117997 Москва, ул. Академика Опарина, 4 

https://orcid.org/0000-0001-8351-8152BozhenkoV. K.БоженкоВ. К.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

86 Profsoyuznaya St., Moscow 117997, Russia

Россия, 117997 Москва, ул. Академика Опарина, 4 

Россия, 117997 Москва, ул. Профсоюзная, 86

https://orcid.org/0009-0000-3757-5025BikeevYu. V.БикеевЮ. В.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

 Россия, 117997 Москва, ул. Академика Опарина, 4 

https://orcid.org/0000-0003-2052-914XMikhalevaL. M.МихалёваЛ. М.
Russian Federation

3 Tsyurupy St., Moscow 117418, Russia

Россия, 117418 Москва, ул. Цюрупы, 3 

https://orcid.org/0000-0001-6396-4948AshrafyanL. A.АшрафянЛ. А.
Russian Federation

4 Akademika Oparina St., Moscow 117198, Russia

Россия, 117997 Москва, ул. Академика Опарина, 4 

V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава РоссииRussian Medical Academy of Postgraduate Education, Ministry of Health of RussiaФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииRussian Scientific Center of Roentgenradiology, Ministry of Health of RussiaФГБУ «Российский научный центр рентгенорадиологии» Минздрава РоссииA.P. Avtsyn Research Institute of Human MorphologyФГБНУ «Научно-исследовательский институт морфологии человека им. акад. А.П. Авцына»03122024204708005112024260220252024https://ojrs.abvpress.ru/ojrs/article/view/1319

 The history of progesterone and progesterone receptors (PR) in breast cancer is as great, as controversial. In this review, we summarize the early history of PR research in breast cancer, debunk the myth that progesterone causes cancer, discuss recent discoveries in PR regulating cellular heterogeneity, attempt to reconcile theories that PR play “good” and “bad” role in tumorigenesis, and discuss new directions that may help elucidate the role of this puzzling hormone and its receptors. 

История изучения прогестерона и прогестероновых рецепторов (ПР) при раке молочной железы сколь легендарна, столь и противоречива. В данном обзоре мы резюмируем раннюю историю изучения  ПР при раке молочной железы, развенчиваем миф о том, что прогестерон вызывает рак, обсуждаем  недавнее открытие того, что ПР регулируют гетерогенность клеток, пытаемся объединить теории,  описывающие ПР как «хорошего» или  «плохого» участника онкогенеза, и обсуждаем новые направления исследований, которые могут помочь  объяснить роль этого загадочного гормона и его  рецепторов. 

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