<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">134</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2012-0-3-4-169-172</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ЛЕЧЕНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Intraperitoneal biotherapy of malignant peritoneal effusions in ovarian cancer patients</article-title><trans-title-group xml:lang="ru"><trans-title>Интраперитонеальная биотерапия у больных с асцитными формами диссеминированного рака яичников</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Titov</surname><given-names>К. S.</given-names></name><name xml:lang="ru"><surname>Титов</surname><given-names>К. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ks-titov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gritsai</surname><given-names>A. N.</given-names></name><name xml:lang="ru"><surname>Грицай</surname><given-names>А. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Demidov</surname><given-names>L. V.</given-names></name><name xml:lang="ru"><surname>Демидов</surname><given-names>Л. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rodionova</surname><given-names>L. M.</given-names></name><name xml:lang="ru"><surname>Родионова</surname><given-names>Л. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kiselevsky</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Киселевский</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mosina</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Мосина</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center RAMS, Moscow</institution></aff><aff><institution xml:lang="ru">ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-09-24" publication-format="electronic"><day>24</day><month>09</month><year>2012</year></pub-date><issue>3-4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>169</fpage><lpage>172</lpage><history><date date-type="received" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-24"><day>24</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2012</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/134">https://ojrs.abvpress.ru/ojrs/article/view/134</self-uri><abstract xml:lang="en"><p>Malignant peritoneal effusions often arise in patients with of ovarian cancer. They are dangerous complication of cancer. Intraperitoneal chemotherapy isn’t always effective and causes side effects. Intraperitoneal interleukin-2 (IL-2) and IL-2 / lymphokine activated killers (LAK) biotherapy is characterised of high efficacy in ovarian cancer patients with malignant peritoneal effusions. The objective effect was 82,6 % аnd 72,0 % accordingly. These results suggest that intraperitoneal biotherapy allows to expand possibilities of malignant peritoneal effusions treat- ment in ovarian cancer patients.</p></abstract><trans-abstract xml:lang="ru"><p>Опухолевые асциты (ОА) наиболее часто сопровождают течение рака яичников (РЯ) и являются серьезными проявлениями диссеминации, нередко рецидивируя после лекарственного лечения. Системная и интраперитонеальная химиотерапия (ХТ) не всегда вызывает длительные ремиссии и при этом является токсичным лечением. Интраперитонеальная иммунотерапия ОА интерлейкином-2 (ИЛ-2) в комбинации с аллогенными лимфокин-активированными киллерами (ЛАК) и ИЛ-2 в монорежиме характеризуется высокой эффективностью и хорошей переносимостью у больных РЯ при неэффективности 2 линий ХТ. Объективный эффект данного лечения составил 82,6 % и 72,0 % соответственно. Предложенный вид биотерапии может рассматриваться как один из этапов комбинированного лечения данной категории больных, при этом имеет хорошую переносимость и улучшает качество их жизни.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ovarian cancer</kwd><kwd>malignant peritoneal effusions</kwd><kwd>interleukin-2</kwd><kwd>LAK-cells</kwd><kwd>intraperitoneal biotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак яичников</kwd><kwd>опухолевые асциты</kwd><kwd>интерлейкин-2</kwd><kwd>ЛАК-клетки</kwd><kwd>интраперитонеальная биотерапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Гарин А.М., Базин И.С. Десять наиболее распространенных злокачественных опухолей. М., 2006. С. 205.</mixed-citation><mixed-citation xml:lang="ru">Гарин А.М., Базин И.С. Десять наиболее распространенных злокачественных опухолей. М., 2006. С. 205.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Давыдов М.И., Летягин В.П., Кузнецов В.В. Рак яичников. В кн.: Опухоли женской репродуктивной системы. М.: Радуга, 2007. С. 164−176; 273−82.</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Летягин В.П., Кузнецов В.В. Рак яичников. В кн.: Опухоли женской репродуктивной системы. М.: Радуга, 2007. С. 164−176; 273−82.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Киселевский М.В., Блюменберг А.Г. Адоптивная иммунотерапия рака яичников. Сборник статей, приуроченный к Европейской школе по онкологии, 2001.</mixed-citation><mixed-citation xml:lang="ru">Киселевский М.В., Блюменберг А.Г. Адоптивная иммунотерапия рака яичников. Сборник статей, приуроченный к Европейской школе по онкологии, 2001.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Markman M. Intraperitoneal chemotherapy of ovarian cancer. Semin Oncol 1998;25:356−60.</mixed-citation><mixed-citation xml:lang="ru">Markman M. Intraperitoneal chemotherapy of ovarian cancer. Semin Oncol 1998;25:356−60.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Feedman R.S., Kudelka A.P., Kavanagh J.J. Clinical and Biological Effects of Intraperitoneal Injections of Recombinant Interferon- and Recombinant Interleukin-2 with or without Tumor-infiltrating Lympho- cytes in Patients with Ovarian or Peritoneal Carcinoma. Clin Cancer Res 2000;6:225−6.</mixed-citation><mixed-citation xml:lang="ru">Feedman R.S., Kudelka A.P., Kavanagh J.J. Clinical and Biological Effects of Intraperitoneal Injections of Recombinant Interferon- and Recombinant Interleukin-2 with or without Tumor-infiltrating Lympho- cytes in Patients with Ovarian or Peritoneal Carcinoma. Clin Cancer Res 2000;6:225−6.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Nagamine I., Yamaguchi Y., Ohara M.et al. Induction of gamma delta T-cells using zoledronate plus interleukin-2 in patients with metastatic cancer. Hiroshima J Med Sci 2009; 58:37−44.</mixed-citation><mixed-citation xml:lang="ru">Nagamine I., Yamaguchi Y., Ohara M.et al. Induction of gamma delta T-cells using zoledronate plus interleukin-2 in patients with metastatic cancer. Hiroshima J Med Sci 2009; 58:37−44.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Pujade-Lauraine E., Guastella J.P., Colombo N. et al. Intraperitoneal ecombinant interferon-γ in ovarian cancer patients with residual disease at second-look laparotomy. J Clin Oncol 1996;14:343−50.</mixed-citation><mixed-citation xml:lang="ru">Pujade-Lauraine E., Guastella J.P., Colombo N. et al. Intraperitoneal ecombinant interferon-γ in ovarian cancer patients with residual disease at second-look laparotomy. J Clin Oncol 1996;14:343−50.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Hua Z., Lit J. Clinical study on immunotherapy of ovarian canser with tumor infiltrating lumphocytes. Chung Yua Fu 1996; 13:555−7.</mixed-citation><mixed-citation xml:lang="ru">Hua Z., Lit J. Clinical study on immunotherapy of ovarian canser with tumor infiltrating lumphocytes. Chung Yua Fu 1996; 13:555−7.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
