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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1366</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2025-21-4-45-52</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Possibilities of breast-conserving surgery in multicentric and multifocal forms of breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности органосохраняющих операций при мультицентричной и мультифокальной формах рака молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-0450-0166</contrib-id><name-alternatives><name xml:lang="en"><surname>Vats</surname><given-names>A. B.</given-names></name><name xml:lang="ru"><surname>Вац</surname><given-names>А. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-3112-8081</contrib-id><contrib-id contrib-id-type="spin">6144-1590</contrib-id><name-alternatives><name xml:lang="en"><surname>Lazakovich</surname><given-names>Alina A.</given-names></name><name xml:lang="ru"><surname>Лазакович</surname><given-names>Алина Алексеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6183-9764</contrib-id><name-alternatives><name xml:lang="en"><surname>Dashyan</surname><given-names>Garik A.</given-names></name><name xml:lang="ru"><surname>Дашян</surname><given-names>Гарик Альбертович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Member of the RSOM Board, MD, PhD, Leading Researcher of the Department of Breast Tumors, N. N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia, Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>член правления РООМ, д.м.н., ведущий научный сотрудник отделения опухолей молочной железы ФГБУ «НМИЦ онкологии им. Н. Н. Петрова» Минздрава России, Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3348-4251</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhmedov</surname><given-names>R. M.</given-names></name><name xml:lang="ru"><surname>Ахмедов</surname><given-names>Р. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-7511-2952</contrib-id><name-alternatives><name xml:lang="en"><surname>Zhurov</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Журов</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9623-3877</contrib-id><name-alternatives><name xml:lang="en"><surname>Shaykhelislamova</surname><given-names>L. F.</given-names></name><name xml:lang="ru"><surname>Шайхелисламова</surname><given-names>Л. Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2274-8170</contrib-id><name-alternatives><name xml:lang="en"><surname>Belousov</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Белоусов</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Clinic of High Medical Technologies named after N. I. Pirogov</p></bio><bio xml:lang="ru"><p>Клиника высоких медицинских технологий им. Н. И. Пирогова</p></bio><email>dr.lazakovich@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Saint Petersburg State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Санкт-Петербургский государственный университет»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-01-20" publication-format="electronic"><day>20</day><month>01</month><year>2026</year></pub-date><volume>21</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>45</fpage><lpage>52</lpage><history><date date-type="received" iso-8601-date="2025-06-26"><day>26</day><month>06</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Vats A.B., Lazakovich A.A., Dashyan G.A., Akhmedov R.M., Zhurov A.S., Shaykhelislamova L.F., Belousov A.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Вац А.Б., Лазакович А.А., Дашян Г.А., Ахмедов Р.М., Журов А.С., Шайхелисламова Л.Ф., Белоусов А.М.</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Vats A.B., Lazakovich A.A., Dashyan G.A., Akhmedov R.M., Zhurov A.S., Shaykhelislamova L.F., Belousov A.M.</copyright-holder><copyright-holder xml:lang="ru">Вац А.Б., Лазакович А.А., Дашян Г.А., Ахмедов Р.М., Журов А.С., Шайхелисламова Л.Ф., Белоусов А.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/1366">https://ojrs.abvpress.ru/ojrs/article/view/1366</self-uri><abstract xml:lang="en"><p>Breast cancer still occupies a leading position among oncological diseases in women, despite the successes in its diagnosis and treatment. Multifocal and multicentric forms of breast cancer, which are characterized by the development of several tumors in one or different quadrants of the mammary gland, remain especially difficult for clinical practice. These features significantly affect the choice of treatment tactics, the scope of surgical intervention and prognosis. The article considers modern approaches to the diagnosis and treatment of multifocal and multicentric forms of breast cancer and analyzes the possibilities and limitations of breast-conserving surgery in these cases.</p></abstract><trans-abstract xml:lang="ru"><p>Рак молочной железы по-прежнему занимает ведущие позиции среди онкологических заболеваний у женщин, несмотря на успехи в его диагностике и лечении. Особенно сложными для клинической практики остаются его мультифокальная и мультицентричная формы, для которых характерно развитие нескольких опухолей в одном или разных квадрантах молочной железы. Эти особенности существенно влияют на выбор лечебной тактики, объем хирургического вмешательства и прогноз. В статье рассматриваются современные подходы к диагностике и лечению мультицентричной и мультифокальной форм рака молочной железы, а также анализируются возможности и ограничения органосохраняющих операций в этих случаях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>multicentric breast cancer</kwd><kwd>multifocal breast cancer</kwd><kwd>breast-conserving surgery</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>мультицентричный рак молочной железы</kwd><kwd>мультифокальный рак молочной железы</kwd><kwd>органосохраняющая операция</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Feng Y., Spezia M., Huang S. et al. Breast cancer development and progression: risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. 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