Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press13710.17650/1994-4098-2011-0-1-19-28MAMMOLOGY. TOPICAL ISSUEМАММОЛОГИЯ. АКТУАЛЬНАЯ ТЕМАCurrent molecular genetic markers of breast cancerСовременные молекулярно-генетические маркеры рака молочной железыApanovichN. V.АпановичН. В.
Russian Federation
apanovich2004@mail.ruShubinV. P.ШубинВ. П.
Russian Federation
KorotayevaA. A.КоротаеваА. А.
Russian Federation
BavykinA. S.БавыкинА. С.
Russian Federation
KimE. A.КимЕ. А.
Russian Federation
ZakiryakhodzhayevA. D.ЗакиряходжаевА. Д.
Russian Federation
LetyaginV. P.ЛетягинВ. П.
Russian Federation
VysotskayaI. V.ВысоцкаяИ. В.
Russian Federation
KarpukhinA. V.КарпухинА. В.
Russian Federation
Molecular Genetics Research Center, Russian Academy of Medical SciencesМГНЦ РАМНN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesРОНЦ им. Н.Н. Блохина РАМНI.M. Sechenov First Moscow State Medical University1-й МГМУ им. И.М. СеченоваMolecular Genetics Research Center, Russian Academy of Medical SciencesМГНЦ РАМНМГНЦ РАМНРОНЦ им. Н.Н. Блохина РАМНMolecular Genetics Research Center, Russian Academy of Medical Sciences1-й МГМУ им. И.М. СеченоваN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesI.M. Sechenov First Moscow State Medical UniversityМГНЦ РАМН1-й МГМУ им. И.М. СеченоваN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesI.M. Sechenov First Moscow State Medical UniversityМГНЦ РАМН1-й МГМУ им. И.М. СеченоваN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesI.M. Sechenov First Moscow State Medical UniversityМГНЦ РАМН1-й МГМУ им. И.М. СеченоваN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesРОНЦ им. Н.Н. Блохина РАМН1-й МГМУ им. И.М. Сеченова250220111192825072014250720142011https://ojrs.abvpress.ru/ojrs/article/view/137

The paper concerns the molecular and genetic markers of breast cancer (BC). For practice use it is expedient to limit a BC expression analysis panel with the VEGFR 1, VEGFR 2, VEGF 121, PDGFR, mTOR, Her-2/neu, Ki-67, BRCA 1, ESR 1, Ostp, BIRC 2 and BIRC 5 genes to accelerate the test and reduce its cost and to simplify interpretation by physicians. These 12 genes carry basic information that is required to choose and predict a chemotherapy response and that serves as its prognostic markers, by indicating the potential therapeutic targets.

Рассмотрены современные молекулярно-генетические маркеры рака молочной железы (РМЖ). Для практического использования с целью ускорения, удешевления анализа и упрощения трактовки практикующими врачами целесообразно ограничить панель для анализа экспрессии при РМЖ генами VEGFR 1, VEGFR 2, VEGF 121, PDGFR, mTOR, Her-2/neu, Ki-67, BRCA 1, ESR 1, Ostp, BIRC 2 и BIRC 5. Эти 12 генов несут основную информацию, необходимую для выбора и прогноза химиотерапевтического лечения и служат прогностическими маркерами ответа на терапию за счет указания на потенциальные мишени терапевтического воздействия.

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