Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press138210.17650/1994-4098-2025-21-2-115-122GYNECOLOGY. REVIEWSГИНЕКОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИBenign metastatic leiomyoma: literature reviewДоброкачественная метастазирующая лейомиома: обзор литературыhttps://orcid.org/0000-0002-0486-2404KotivKh. B.КотивХ. Б.
Russian Federation

Khristina Bogdanovna Kotiv

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

41 Kirochnaya St., Saint Petersburg 191015

Христина Богдановна Котив

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

191015 Санкт-Петербург, ул. Кирочная, 41

kotiv.onc@gmail.comKhmelevskaiaE. M.ХмелевскаяЕ. М.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

41 Kirochnaya St., Saint Petersburg 191015

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

191015 Санкт-Петербург, ул. Кирочная, 41

https://orcid.org/0000-0001-6937-2740BerlevI. V.БерлевИ. В.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

41 Kirochnaya St., Saint Petersburg 191015

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

191015 Санкт-Петербург, ул. Кирочная, 41

N. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова» Минздрава РоссииI. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Минздрава России030820252121151220208202502082025https://ojrs.abvpress.ru/ojrs/article/view/1382

The review systematises literature data on pathogenesis, clinical course and treatment of benign metastasising leiomyoma. Benign metastatic leiomyoma is a rare disease, occurring in women of reproductive period, characterised by the presence of multiple benign indolent smooth-muscle mitotically inactive tumours (metastases) of ectopic localisation with a history of uterine leiomyoma and no other tumour process. It is presented in various forms: peritoneal leiomyomatosis, intravenous leiomyomatosis involvement of parenchymal organs, bones, skeletal muscles. Currently, there are no standards for the treatment of patients with benign metastasising leiomyoma. Treatment depends on localisation of metastases and clinical manifestations of the disease: dynamic observation, hormone therapy or surgical treatment.

В обзоре систематизированы данные о патогенезе, клиническом течении и терапии доброкачественной метастази рующей лейомиомы. Доброкачественная метастазирующая лейомиома – редкое заболевание, встречающееся у женщин репродуктивного возраста, характеризуется развитием множественных доброкачественных гладкомы шечных митотически неактивных опухолей (метастазов) внематочной локализации с индолентным течением при наличии лейомиомы матки в анамнезе и отсутствии данных, указывающих на иной опухолевый процесс. Пред ставлена в различных формах: перитонеальный лейомиоматоз, интравенозный лейомиоматоз, поражение паренхиматозных органов, костей, скелетных мышц. В настоящее время отсутствуют стандарты лечения больных добро качественной метастазирующей лейомиомой. Тактика зависит от локализации метастазов и клинических проявлений заболевания: динамическое наблюдение, гормонотерапия, хирургическое лечение.

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