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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1388</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2025-21-4-136-145</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Artificial intelligence in gynecologic oncology: current status and development prospects</article-title><trans-title-group xml:lang="ru"><trans-title>Применение искусственного интеллекта в онкогинекологии: современное состояние и перспективы развития</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7124-1652</contrib-id><name-alternatives><name xml:lang="en"><surname>Kalkina</surname><given-names>Gulnara N.</given-names></name><name xml:lang="ru"><surname>Калькина</surname><given-names>Гульнара Нургалыевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Research Institute of Oncology</p></bio><bio xml:lang="ru"><p>Научно-исследовательский институт онкологии</p></bio><email>dr.gulnara98@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3439-8830</contrib-id><name-alternatives><name xml:lang="en"><surname>Churuksaeva</surname><given-names>O. N.</given-names></name><name xml:lang="ru"><surname>Чуруксаева</surname><given-names>О. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Research Institute of Oncology</p></bio><bio xml:lang="ru"><p>Научно-исследовательский институт онкологии</p></bio><email>dr.gulnara98@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6854-8940</contrib-id><name-alternatives><name xml:lang="en"><surname>Kolomiets</surname><given-names>Larisa A.</given-names></name><name xml:lang="ru"><surname>Коломиец</surname><given-names>Лариса Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Head of the Department of Gynecologic Oncology, Research Institute of Oncology</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, заведующая отделением гинекологии отдела клинической онкологии, Научно-исследовательский институт онкологии</p></bio><email>dr.gulnara98@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tomsk National Research Medical Center, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-01-20" publication-format="electronic"><day>20</day><month>01</month><year>2026</year></pub-date><volume>21</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>136</fpage><lpage>145</lpage><history><date date-type="received" iso-8601-date="2025-08-26"><day>26</day><month>08</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, .</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Калькина Г.Н.</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">.</copyright-holder><copyright-holder xml:lang="ru">Калькина Г.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/1388">https://ojrs.abvpress.ru/ojrs/article/view/1388</self-uri><abstract xml:lang="en"><p>Gynecologic oncology is a significant challenge for modern healthcare, requiring innovative approaches to diagnosis, treatment, and outcome prediction. Artificial intelligence (AI) is revolutionizing oncology practice, opening up new opportunities to improve the care of patients with gynecologic malignancies. This review assesses the current state of AI use in gynecologic oncology based on a systematic literature review. The methodology included searching in PubMed, Web of Science, and Scopus databases for the period 2010–2024 using the key terms “artificial intelligence”, “machine learning”, and “deep learning” in combination with “cervical cancer”, “ovarian cancer”, and “endometrial cancer”. The results show that of the 71 studies, 34 focused on cervical cancer, 21 – on ovarian cancer, and 13 – on endometrial cancer, with 49 % of the studies using imaging data and 51 % using numerical data. AI demonstrates high accuracy in cervical cancer screening (up to 95 %), significantly improves outcome prediction in ovarian cancer (AUC 0.77–0.88), and shows promising results in endometrial cancer diagnosis. Radiomics-based machine learning models achieve a C-index of 0.85 for predicting disease-free survival and overall survival in cervical cancer after chemoradiation therapy. The discussion highlights the theoretical significance of AI for personalized medicine in gynecologic oncology and its practical importance for improving clinical outcomes, but also highlights the need to address validation issues, ethical considerations, and integration into clinical practice. Prospects include the development of multimodal models, the integration of more data, and the creation of explainable algorithms to enhance clinician confidence.</p></abstract><trans-abstract xml:lang="ru"><p>Онкогинекологические заболевания представляют значительную проблему современного здравоохранения, требующую внедрения инновационных подходов к диагностике, лечению и прогнозированию исходов. Искусственный интеллект (ИИ) революционизирует онкологическую практику, открывая новые возможности для улучшения ведения пациентов с гинекологическими злокачественными новообразованиями. Данный обзор посвящен оценке современного состояния применения ИИ в онкогинекологии на основе систематического анализа литературы. Методология включала поиск в базах данных PubMed, Web of Science и Scopus за период 2010–2024 гг. с использованием ключевых терминов «искусственный интеллект», «машинное обучение», «глубокое обучение» в сочетании с терминами «рак шейки матки», «рак яичников», «рак эндометрия». Результаты показывают, что из 71 исследования 34 посвящены раку шейки матки, 21 – раку яичников и 13 – раку эндометрия, при этом 49 % исследований использовали данные визуализации, а 51 % – числовые данные. ИИ демонстрирует высокую точность в скрининге рака шейки матки (до 95 %), значительно улучшает прогнозирование исходов при раке яичников (AUC 0,77–0,88) и показывает многообещающие результаты в диагностике рака эндометрия. Радиомические модели машинного обучения достигают C-индекса 0,85 для прогнозирования выживаемости без болезни и общей выживаемости при раке шейки матки после химиолучевой терапии. Дискуссия выявляет теоретическую значимость ИИ для персонализированной медицины в онкогинекологии и его практическую важность для улучшения клинических исходов, однако отмечает необходимость решения проблем валидации, этических аспектов и интеграции в клиническую практику. Перспективы включают развитие мультимодальных моделей, интеграцию большего количества данных и создание объяснимых алгоритмов для повышения доверия клиницистов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>artificial intelligence</kwd><kwd>gynecologic oncology</kwd><kwd>machine learning</kwd><kwd>deep learning</kwd><kwd>radiomics</kwd><kwd>personalized medicine</kwd><kwd>cancer diagnostics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>искусственный интеллект</kwd><kwd>онкогинекология</kwd><kwd>машинное обучение</kwd><kwd>глубокое обучение</kwd><kwd>радиомика</kwd><kwd>персонализированная медицина</kwd><kwd>диагностика рака</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Paiboonborirak C., Abu-Rustum N.R., Wilailak S. Artificial intelligence in gynaecological malignancies: perspectives of a clinical oncologist. Cureus 2023;15(10):e47889. 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