Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press15010.17650/1994-4098-2011-0-1-96-105GYNECOLOGY. DIAGNOSISГИНЕКОЛОГИЯ. ДИАГНОСТИКАEarly response genes in the pathogenesis of cancer of the cervix uteri: a reviewГены раннего ответа в патогенезе рака шейки матки: обзорKurmyshkinaO. V.КурмышкинаО. В.
Russian Federation
VolkovaT. O.ВолковаТ. О.
Russian Federation
VolkovaTO@yandex.ruKovchurP. I.КовчурП. И.
Russian Federation
BakhlayevI. E.БахлаевИ. Е.
Russian Federation
NemovaN. N.НемоваН. Н.
Russian Federation
Petrozavodsk State UniversityПетрозаводский государственный университет, Петрозаводск, КарелияPetrozavodsk State UniversityПетрозаводский государственный университетInstitute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, KareliaИнститут биологии КарНЦ РАН, Петрозаводск, Карелия2502201119610525072014250720142011https://ojrs.abvpress.ru/ojrs/article/view/150

Early response genes are a group of proto-oncogenes that are the first to be activated in cell stimulation with different growth factors and to be involved in the regulation of cell proliferation and differentiation. Large amount of information supporting that altered expression of these genes is one of the central and earliest events of carcinogenesis has been accumulated. In this connection, it is promising to use early response genes as diagnostic and prognostic markers for the detection and combination therapy of cancer of the cervix uteri, one of the most common gynecological malignancies characterized by high mortality rates and difficulties in early diagnosis. The theoretical basis for these promises is the found mechanisms for the interaction of early response genes with human papillomavirus genome, the main cause of cervix uteri cancer.

Гены раннего ответа — это группа протоонкогенов, в числе первых активирующихся при стимуляции клетки различными ростовыми факторами и участвующих в регуляции клеточной пролиферации и дифференцировки. Накоплен большой объем данных, подтверждающих, что изменение экспрессии данных генов является одним из центральных и наиболее ранних событий канцерогенеза. В связи с этим представляется перспективным использование генов раннего ответа в качестве диагностических и прогностических маркеров для выявления и комплексной терапии рака шейки матки — одного из наиболее распространенных онко-гинекологических заболеваний, характеризующихся высоким показателем смертности и сложностью ранней диагностики. Теоретическую основу данных перспектив составляют обнаруженные механизмы взаимодействия генов раннего ответа с геномом вируса папилломы человека — главной причиной развития рака шейки матки.

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