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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">160</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2011-0-2-41-44</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY.  PHARMACOTHERAPY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ФАРМАКОТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Present and future of breast cancer anti-Her-2-therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Настоящее и будущее анти-Her-2-терапии рака молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Letyagin</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Летягин</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>levipa@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">РОНЦ им Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-05-25" publication-format="electronic"><day>25</day><month>05</month><year>2011</year></pub-date><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>41</fpage><lpage>44</lpage><history><date date-type="received" iso-8601-date="2014-07-25"><day>25</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-25"><day>25</day><month>07</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/160">https://ojrs.abvpress.ru/ojrs/article/view/160</self-uri><abstract xml:lang="en"><p>The paper describes a new class of molecular targeted antitumor agents against the molecules involved in carcinogenesis. It considers the basic drugs of this class and their combinations and evaluates the efficiency of their use in therapy for breast cancer.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен новый класс противоопухолевых препаратов молекулярно-направленного действия (таргетных), мишенью которых являются молекулы, принимающие участие в канцерогенезе. Рассмотрены основные препараты данного класса и их комбинации, проведена оценка эффективности применения их в терапии рака молочной железы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>target therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>таргетная терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Gasparini G., Longo R., Torino F. et al. Therapy of breast cancer with molecular targeting agents. Ann Oncol 2005;16(Suppl 4):28–36.</mixed-citation><mixed-citation xml:lang="ru">Gasparini G., Longo R., Torino F. et al. Therapy of breast cancer with molecular targeting agents. Ann Oncol 2005;16(Suppl 4):28–36.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Roskoski R. Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004;319:1–11.</mixed-citation><mixed-citation xml:lang="ru">Roskoski R. Jr. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004;319:1–11.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Stern D.F. Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Res 2000;2:176–83.</mixed-citation><mixed-citation xml:lang="ru">Stern D.F. Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Res 2000;2:176–83.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Lin N.U., Winer E.P. New targets for therapy in breast cancer: small molecule tyrosine kinase inhibitors. Breast Cancer Res 2004;6:204–10.</mixed-citation><mixed-citation xml:lang="ru">Lin N.U., Winer E.P. New targets for therapy in breast cancer: small molecule tyrosine kinase inhibitors. Breast Cancer Res 2004;6:204–10.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Riese D.J. 2nd, Stern D.F. Specificity within the EGF family/ErbB receptorfamily signaling network. Bioessays 1998;20:41–8.</mixed-citation><mixed-citation xml:lang="ru">Riese D.J. 2nd, Stern D.F. Specificity within the EGF family/ErbB receptorfamily signaling network. Bioessays 1998;20:41–8.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Mills G.B., Lu Y., Fang X. et al. The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin Oncol 2001;28(Suppl 16):125–41.</mixed-citation><mixed-citation xml:lang="ru">Mills G.B., Lu Y., Fang X. et al. The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin Oncol 2001;28(Suppl 16):125–41.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Salomon D.S., Brandt R., Ciardiello F. et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183–232.</mixed-citation><mixed-citation xml:lang="ru">Salomon D.S., Brandt R., Ciardiello F. et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183–232.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Slamon D.J., Clark G.M., Wong S.G. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER- 2/neu oncogene. Science 1987;235:177–82.</mixed-citation><mixed-citation xml:lang="ru">Slamon D.J., Clark G.M., Wong S.G. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER- 2/neu oncogene. Science 1987;235:177–82.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Tsutsui S., Ohno S., Murakami S. et al. Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer. Breast Cancer Res Treat 2002;71:67–75.</mixed-citation><mixed-citation xml:lang="ru">Tsutsui S., Ohno S., Murakami S. et al. Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer. Breast Cancer Res Treat 2002;71:67–75.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Slamon D.J., Godolphin W., Jones L.A. et al. Studies of the HER-2/neu proto- oncogene in human breast and ovarian cancer. Science 1989;244:707–12.</mixed-citation><mixed-citation xml:lang="ru">Slamon D.J., Godolphin W., Jones L.A. et al. Studies of the HER-2/neu proto- oncogene in human breast and ovarian cancer. Science 1989;244:707–12.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Cho H.S., Mason K., Ramyar K.X. et al. Structure of the extracellular regionof HER2 alone and in complex with the Herceptin Fab. Nature 2003;421:756–60.</mixed-citation><mixed-citation xml:lang="ru">Cho H.S., Mason K., Ramyar K.X. et al. Structure of the extracellular regionof HER2 alone and in complex with the Herceptin Fab. Nature 2003;421:756–60.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Slamon D.J., Leyland-Jones B., Shak S. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783–92.</mixed-citation><mixed-citation xml:lang="ru">Slamon D.J., Leyland-Jones B., Shak S. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783–92.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Smith I., Procter M., Gelber R.D. et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369:29–36.</mixed-citation><mixed-citation xml:lang="ru">Smith I., Procter M., Gelber R.D. et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369:29–36.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Romond E.H., Perez E.A., Bryant J. et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673–84.</mixed-citation><mixed-citation xml:lang="ru">Romond E.H., Perez E.A., Bryant J. et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673–84.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Nahta R., Yu D., Hung M.C. et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006;3:269–80.</mixed-citation><mixed-citation xml:lang="ru">Nahta R., Yu D., Hung M.C. et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006;3:269–80.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Pegram M.D. Challenges in HER2- positive breast cancer. Educational book. ASCO 2011:8–13.</mixed-citation><mixed-citation xml:lang="ru">Pegram M.D. Challenges in HER2- positive breast cancer. Educational book. ASCO 2011:8–13.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Geyer C.E., Forster J., Lindquist D. et al. Lapatinib plus capecitabine for Her- 2-positive advanced breast cancer. N Engl J Med 2006;355:2733–43.</mixed-citation><mixed-citation xml:lang="ru">Geyer C.E., Forster J., Lindquist D. et al. Lapatinib plus capecitabine for Her- 2-positive advanced breast cancer. N Engl J Med 2006;355:2733–43.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Cameron D., Casey M., Press M. et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008;112(3):533–43.</mixed-citation><mixed-citation xml:lang="ru">Cameron D., Casey M., Press M. et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008;112(3):533–43.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Johnston S., Pippen J.Jr., Pivot X. et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol</mixed-citation><mixed-citation xml:lang="ru">Johnston S., Pippen J.Jr., Pivot X. et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">2009;27(33):5538.</mixed-citation><mixed-citation xml:lang="ru">;27(33):5538.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">20. Lin N.U., Carey L.A., Liu M.C. et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2008;26:1993–9.</mixed-citation><mixed-citation xml:lang="ru">Lin N.U., Carey L.A., Liu M.C. et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2008;26:1993–9.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">21. Boccardo F., Kaufman B., Baselga J. et al. Evaluation of lapatinib (Lap) plus capecitabine (Cap) in patients with brain metastases (BM) from HER2-breast cancer (BC) enrolled in the Lapatinib Expanded Access Program (LEAP) and French Authorisation Temporaire d’Utilisation (ATU). J Clin Oncol 2008;26(15 Suppl):64; abstr 1094.</mixed-citation><mixed-citation xml:lang="ru">Boccardo F., Kaufman B., Baselga J. et al. Evaluation of lapatinib (Lap) plus capecitabine (Cap) in patients with brain metastases (BM) from HER2-breast cancer (BC) enrolled in the Lapatinib Expanded Access Program (LEAP) and French Authorisation Temporaire d’Utilisation (ATU). J Clin Oncol 2008;26(15 Suppl):64; abstr 1094.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">22. Lin N.U., Diéras V., Paul D. et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2- positive breast cancer. Clin Cancer Res 2009;15:1452–9.</mixed-citation><mixed-citation xml:lang="ru">Lin N.U., Diéras V., Paul D. et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2- positive breast cancer. Clin Cancer Res 2009;15:1452–9.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">23. www.clinicaltrials.gov</mixed-citation><mixed-citation xml:lang="ru">www.clinicaltrials.gov</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">24. Rugo H.S., Franco S., Munster P. et al. A phase II evaluation of lapatinib (L) and bevacizumab (B) in HER2+ metastatic breast cancer (MBC). J Clin Oncol 2008;26(15 Suppl):51; abstr 1042.</mixed-citation><mixed-citation xml:lang="ru">Rugo H.S., Franco S., Munster P. et al. A phase II evaluation of lapatinib (L) and bevacizumab (B) in HER2+ metastatic breast cancer (MBC). J Clin Oncol 2008;26(15 Suppl):51; abstr 1042.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">25. Slamon D., Gomez H.L., Kabbinavar F.F. et al. Randomized study of pazopanib + lapatinib vs. lapatinib alone in patients with HER2- positive advanced or metastatic breast cancer. J Clin Oncol 2008;26(15 Suppl):45; abstr 1016.</mixed-citation><mixed-citation xml:lang="ru">Slamon D., Gomez H.L., Kabbinavar F.F. et al. Randomized study of pazopanib + lapatinib vs. lapatinib alone in patients with HER2- positive advanced or metastatic breast cancer. J Clin Oncol 2008;26(15 Suppl):45; abstr 1016.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">26. O’Shaughnessy J., Blackwell K.L., Burstein H.J. et al. A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy. J Clin Oncol 2008;26(15 Suppl):44; abstr 1015.</mixed-citation><mixed-citation xml:lang="ru">O’Shaughnessy J., Blackwell K.L., Burstein H.J. et al. A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy. J Clin Oncol 2008;26(15 Suppl):44; abstr 1015.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">27. Bernard-Marty C., Lebrun F., Awada A., Piccart M.J. Monoclonal antibody-based targeted therapy in breast cancer: current status and future directions. Drugs 2006;66:1577–91.</mixed-citation><mixed-citation xml:lang="ru">Bernard-Marty C., Lebrun F., Awada A., Piccart M.J. Monoclonal antibody-based targeted therapy in breast cancer: current status and future directions. Drugs 2006;66:1577–91.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">28. Agus D.B., Gordon M.S., Taylor C. et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol 2005;23:2534–43.</mixed-citation><mixed-citation xml:lang="ru">Agus D.B., Gordon M.S., Taylor C. et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol 2005;23:2534–43.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">29. Hayes D.F., Yamauchi H., Broadwater G. et al. for the Cancer and Leukemia Group B. Circulating HER-2/erbB-2/c-neu (HER-2) extracellular domain as a prognostic factor in patients with metastatic breast cancer: Cancer and Leukemia Group B Study 8662. Clin Cancer Res 2001;7:2703–11.</mixed-citation><mixed-citation xml:lang="ru">Hayes D.F., Yamauchi H., Broadwater G. et al. for the Cancer and Leukemia Group B. Circulating HER-2/erbB-2/c-neu (HER-2) extracellular domain as a prognostic factor in patients with metastatic breast cancer: Cancer and Leukemia Group B Study 8662. Clin Cancer Res 2001;7:2703–11.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">30. Baselga J., Gelmon K.A, Verma S. et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during</mixed-citation><mixed-citation xml:lang="ru">Baselga J., Gelmon K.A, Verma S. et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><mixed-citation>prior trastuzumab therapy. J Clin Oncol 2010;28(7):1138–44.</mixed-citation></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">31. Cortés J., Baselga J., Petrella T. et al. Pertuzumab monotherapy following trastuzumab-based treatment: activity and tolerability in patients with advanced HER2-positive breast cancer. J Clin Oncol 2009;27(15):1022.</mixed-citation><mixed-citation xml:lang="ru">Cortés J., Baselga J., Petrella T. et al. Pertuzumab monotherapy following trastuzumab-based treatment: activity and tolerability in patients with advanced HER2-positive breast cancer. J Clin Oncol 2009;27(15):1022.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">32. Rabindran S.K., Discafani C.M., Rosfjord E.C. et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004;64:3958–65.</mixed-citation><mixed-citation xml:lang="ru">Rabindran S.K., Discafani C.M., Rosfjord E.C. et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004;64:3958–65.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">33. Wong K.K., Fracasso P.M., Bukowski R.M. et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res 2009;15:2552–8.</mixed-citation><mixed-citation xml:lang="ru">Wong K.K., Fracasso P.M., Bukowski R.M. et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res 2009;15:2552–8.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">34. Krop I.E., Mita M., Burris H.A. et al. A phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients with advanced HER2+ breast cancer. Presented at: 31st Annual San Antonio Breast Cancer Symposium; December 10–14, 2008 San Antonio, TX. J Clin Oncol 2008;26(15 Suppl):1029; abstr 3136.</mixed-citation><mixed-citation xml:lang="ru">Krop I.E., Mita M., Burris H.A. et al. A phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients with advanced HER2+ breast cancer. Presented at: 31st Annual San Antonio Breast Cancer Symposium; December 10–14, 2008 San Antonio, TX. J Clin Oncol 2008;26(15 Suppl):1029; abstr 3136.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
