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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">163</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2011-0-2-56-64</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. DIAGNOSIS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ДИАГНОСТИКА</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Proteomics in the diagnosis of ovarian cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Протеомика в диагностике рака яичников</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shevchenko</surname><given-names>V. E.</given-names></name><name xml:lang="ru"><surname>Шевченко</surname><given-names>В. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>vshev@nm.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Arnotskaya</surname><given-names>N. E.</given-names></name><name xml:lang="ru"><surname>Арноцкая</surname><given-names>Н. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Makarov</surname><given-names>D. E.</given-names></name><name xml:lang="ru"><surname>Макаров</surname><given-names>Д. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pogosyan</surname><given-names>N. R.</given-names></name><name xml:lang="ru"><surname>Погосян</surname><given-names>Н. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhordania</surname><given-names>K. I.</given-names></name><name xml:lang="ru"><surname>Жорданиа</surname><given-names>К. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Oncoproteomics Laboratory, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">Лаборатория онкопротеомики  им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Gynecology Department N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">Гинекологическое отделение РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-05-25" publication-format="electronic"><day>25</day><month>05</month><year>2011</year></pub-date><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>56</fpage><lpage>64</lpage><history><date date-type="received" iso-8601-date="2014-08-11"><day>11</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-11"><day>11</day><month>08</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/163">https://ojrs.abvpress.ru/ojrs/article/view/163</self-uri><abstract xml:lang="en"><p>Proteomics has recently found wide application to account for the molecular mechanisms of cancer and to search for biomarkers that may be used to diagnose and/or predict the development of the disease. The paper briefly reviews proteomic studies to detect ovarian cancer biomarkers, by taking into account different types of biological samples.</p></abstract><trans-abstract xml:lang="ru"><p>В последнее время протеомика находит широкое применение для объяснения молекулярных механизмов возникновения рака и поиска биомаркеров, которые могут использоваться для диагностики и/или прогноза развития заболевания. В статье представлен краткий обзор протеомных исследований по обнаружению биомаркеров рака яичников с учетом различных типов биологических образцов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ovarian cancer</kwd><kwd>proteomics</kwd><kwd>biomarkers</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак яичников</kwd><kwd>протеомика</kwd><kwd>биомаркеры</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Heintz A.P., Odicino F., Maisonneuve P. et al. Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet 2006;95(Suppl 1):161–92.</mixed-citation><mixed-citation xml:lang="ru">Heintz A.P., Odicino F., Maisonneuve P. et al. Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet 2006;95(Suppl 1):161–92.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Young R.C., Walton L.A., Ellenberg S.S. et al. Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials. N Engl J Med 1990;322(15):1021–7.</mixed-citation><mixed-citation xml:lang="ru">Young R.C., Walton L.A., Ellenberg S.S. et al. Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials. N Engl J Med 1990;322(15):1021–7.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Armstrong D.K., Bundy B., Wenzel L. et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med 2006;354(1):34–43.</mixed-citation><mixed-citation xml:lang="ru">Armstrong D.K., Bundy B., Wenzel L. et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med 2006;354(1):34–43.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Markman M., Walker J.L. Intraperitoneal chemotherapy of ovarian cancer: a review, with a focus on practical aspects of treatment. J Clin Oncol 2006;24(6):988–94.</mixed-citation><mixed-citation xml:lang="ru">Markman M., Walker J.L. Intraperitoneal chemotherapy of ovarian cancer: a review, with a focus on practical aspects of treatment. J Clin Oncol 2006;24(6):988–94.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Adam B.L., Qu Y., Davis J.W. et al. Serum protein fingerprinting coupled with a pattern- matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. Cancer Res 2002;62(13):3609– 14.</mixed-citation><mixed-citation xml:lang="ru">Adam B.L., Qu Y., Davis J.W. et al. Serum protein fingerprinting coupled with a pattern- matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. Cancer Res 2002;62(13):3609– 14.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Jacobs I.J., Menon U. Progress and challenges in screening for early detection of ovarian cancer. Mol Cell Proteom 2004;3(4):355–66.</mixed-citation><mixed-citation xml:lang="ru">Jacobs I.J., Menon U. Progress and challenges in screening for early detection of ovarian cancer. Mol Cell Proteom 2004;3(4):355–66.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Rai A.J., Zhang Z., Rosenzweig J. et al. Proteomic approaches to tumor marker discovery. Arch Pathol Lab Med 2002;126(12):1518–26.</mixed-citation><mixed-citation xml:lang="ru">Rai A.J., Zhang Z., Rosenzweig J. et al. Proteomic approaches to tumor marker discovery. Arch Pathol Lab Med 2002;126(12):1518–26.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Sedlakova I., Vavrova J., Tosner J., Hanousek L. Lysophosphatidic acid: an ovarian cancer marker. Eur J Gynaecol Oncol 2008;29(5):511–4.</mixed-citation><mixed-citation xml:lang="ru">Sedlakova I., Vavrova J., Tosner J., Hanousek L. Lysophosphatidic acid: an ovarian cancer marker. Eur J Gynaecol Oncol 2008;29(5):511–4.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Moore R.G., McMeekin D.S., Brown A.K. et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol 2009;112(1):40–6.</mixed-citation><mixed-citation xml:lang="ru">Moore R.G., McMeekin D.S., Brown A.K. et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol 2009;112(1):40–6.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Visintin I., Feng Z., Longton G. et al. Diagnostic markers for early detection of ovarian cancer. Clin Cancer Res 2008;14(4):1065–72.</mixed-citation><mixed-citation xml:lang="ru">Visintin I., Feng Z., Longton G. et al. Diagnostic markers for early detection of ovarian cancer. Clin Cancer Res 2008;14(4):1065–72.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Ward B.G., McGuckin M.A., Ramm L.E. et al. The management of ovarian carcinoma is improved by the use of cancer-associated serum antigen and CA 125 assays. Cancer 1993;71(2):430–8.</mixed-citation><mixed-citation xml:lang="ru">Ward B.G., McGuckin M.A., Ramm L.E. et al. The management of ovarian carcinoma is improved by the use of cancer-associated serum antigen and CA 125 assays. Cancer 1993;71(2):430–8.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Moore R.G., Brown A.K., Miller M.C. et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol 2008;108(2):402–8.</mixed-citation><mixed-citation xml:lang="ru">Moore R.G., Brown A.K., Miller M.C. et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol 2008;108(2):402–8.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Jacobs I., Davies A.P., Bridges J. et al. Prevalence screening for ovarian cancer in postmenopausal women by CA 125 measurement and ultrasonography. BMJ 1993;306(6884):1030–4.</mixed-citation><mixed-citation xml:lang="ru">Jacobs I., Davies A.P., Bridges J. et al. Prevalence screening for ovarian cancer in postmenopausal women by CA 125 measurement and ultrasonography. BMJ 1993;306(6884):1030–4.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Woolas R.P., Conaway M.R., Xu F. et al. Combinations of multiple serum markers are superior to individual assays for discriminating malignant from benign pelvic masses. Gynecol Oncol 1995;59(1):111–6.</mixed-citation><mixed-citation xml:lang="ru">Woolas R.P., Conaway M.R., Xu F. et al. Combinations of multiple serum markers are superior to individual assays for discriminating malignant from benign pelvic masses. Gynecol Oncol 1995;59(1):111–6.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Zhang Z., Barnhill S.D., Zhang H. et al. Combination of multiple serum markers using an artificial neural network to improve specificity in discriminating malignant from benign pelvic masses. Gynecol Oncol 1999;73(1):56–61.</mixed-citation><mixed-citation xml:lang="ru">Zhang Z., Barnhill S.D., Zhang H. et al. Combination of multiple serum markers using an artificial neural network to improve specificity in discriminating malignant from benign pelvic masses. Gynecol Oncol 1999;73(1):56–61.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Skates S.J., Horick N., Yu Y. et al. Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions. J Clin Oncol 2004;22(20):4059–66.</mixed-citation><mixed-citation xml:lang="ru">Skates S.J., Horick N., Yu Y. et al. Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions. J Clin Oncol 2004;22(20):4059–66.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Petricoin E.F., Ardekani A.M., Hitt B.A. et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 2002;359(9306):572–7.</mixed-citation><mixed-citation xml:lang="ru">Petricoin E.F., Ardekani A.M., Hitt B.A. et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 2002;359(9306):572–7.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Omenn G.S., States D.J., Adamski M. et al. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 2005;5(13):3226–45.</mixed-citation><mixed-citation xml:lang="ru">Omenn G.S., States D.J., Adamski M. et al. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics 2005;5(13):3226–45.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Tammen H., Schulte I., Hess R. et al. Peptidomic analysis of human blood specimens: comparison between plasma specimens and serum by differential peptide display. Proteomics 2005;5(13):3414–22.</mixed-citation><mixed-citation xml:lang="ru">Tammen H., Schulte I., Hess R. et al. Peptidomic analysis of human blood specimens: comparison between plasma specimens and serum by differential peptide display. Proteomics 2005;5(13):3414–22.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Baggerly K.A., Morris J.S., Coombes K.R. Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics 2004;20(5):777–85.</mixed-citation><mixed-citation xml:lang="ru">Baggerly K.A., Morris J.S., Coombes K.R. Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments. Bioinformatics 2004;20(5):777–85.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Elwood M. Proteomic patterns in serum and identification of ovarian cancer. Lancet 2002;360(9327):170–1.</mixed-citation><mixed-citation xml:lang="ru">Elwood M. Proteomic patterns in serum and identification of ovarian cancer. Lancet 2002;360(9327):170–1.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Diamandis E.P. Proteomic patterns in serum and identification of ovarian cancer. Lancet 2002;360(9327):170–1.</mixed-citation><mixed-citation xml:lang="ru">Diamandis E.P. Proteomic patterns in serum and identification of ovarian cancer. Lancet 2002;360(9327):170–1.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Diamandis E.P. Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitations. Mol Cell Proteom 2004;3(4):367–78.</mixed-citation><mixed-citation xml:lang="ru">Diamandis E.P. Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitations. Mol Cell Proteom 2004;3(4):367–78.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Daly M.B., Ozols R.F. The search for predictive patterns in ovarian cancer: proteomics meets bioinformatics. Cancer Cell 2002;1(2):111–2.</mixed-citation><mixed-citation xml:lang="ru">Daly M.B., Ozols R.F. The search for predictive patterns in ovarian cancer: proteomics meets bioinformatics. Cancer Cell 2002;1(2):111–2.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Conrads T.P., Fusaro V.A., Ross S. et al. High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer 2004;11(2):163–78.</mixed-citation><mixed-citation xml:lang="ru">Conrads T.P., Fusaro V.A., Ross S. et al. High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer 2004;11(2):163–78.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Baggerly K.A., Edmonson S.R., Morris J.S., Coombes K.R. High-resolution serum proteomic patterns for ovarian cancer detection. Endocr Relat Cancer 2004;11(4):583–7.</mixed-citation><mixed-citation xml:lang="ru">Baggerly K.A., Edmonson S.R., Morris J.S., Coombes K.R. High-resolution serum proteomic patterns for ovarian cancer detection. Endocr Relat Cancer 2004;11(4):583–7.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Ye B., Cramer D.W., Skates S.J. et al. Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry. Clin Cancer Res 2003;9(8):2904–11.</mixed-citation><mixed-citation xml:lang="ru">Ye B., Cramer D.W., Skates S.J. et al. Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry. Clin Cancer Res 2003;9(8):2904–11.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Ahmed N., Barker G., Oliva K.T. et al. Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer. Br J Cancer 2004;91(1):129–40.</mixed-citation><mixed-citation xml:lang="ru">Ahmed N., Barker G., Oliva K.T. et al. Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer. Br J Cancer 2004;91(1):129–40.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Kozak K.R., Amneus M.W., Pusey S.M. et al. Identification of biomarkers for ovarian cancer using strong anion-exchange ProteinChips: potential use in diagnosis and prognosis. Proc Natl Acad Sci USA 2003;100(21):12343–8.</mixed-citation><mixed-citation xml:lang="ru">Kozak K.R., Amneus M.W., Pusey S.M. et al. Identification of biomarkers for ovarian cancer using strong anion-exchange ProteinChips: potential use in diagnosis and prognosis. Proc Natl Acad Sci USA 2003;100(21):12343–8.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Kozak K.R., Su F., Whitelegge J.P. et al. Characterization of serum biomarkers for detection of early stage ovarian cancer. Proteomics 2005;5(17):4589–96.</mixed-citation><mixed-citation xml:lang="ru">Kozak K.R., Su F., Whitelegge J.P. et al. Characterization of serum biomarkers for detection of early stage ovarian cancer. Proteomics 2005;5(17):4589–96.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Woong-Shick A., Sung-Pil P., Su-Mi B. et al. Identification of hemoglobin-alpha and -beta subunits as potential serum biomarkers for the diagnosis and prognosis of ovarian cancer. Cancer Sci 2005;96(3):197–201.</mixed-citation><mixed-citation xml:lang="ru">Woong-Shick A., Sung-Pil P., Su-Mi B. et al. Identification of hemoglobin-alpha and -beta subunits as potential serum biomarkers for the diagnosis and prognosis of ovarian cancer. Cancer Sci 2005;96(3):197–201.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Zhang Z., Bast R.C. Jr., Yu Y. et al. Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res 2004;64(16):5882–90.</mixed-citation><mixed-citation xml:lang="ru">Zhang Z., Bast R.C. Jr., Yu Y. et al. Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res 2004;64(16):5882–90.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Ahmed N., Oliva K.T., Barker G. et al. Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer. Proteomics 2005;5(17):4625–36.</mixed-citation><mixed-citation xml:lang="ru">Ahmed N., Oliva K.T., Barker G. et al. Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer. Proteomics 2005;5(17):4625–36.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Yu J.K., Zheng S., Tang Y., Li L. An integrated approach utilizing proteomics and bioinformatics to detect ovarian cancer. J Zhejiang Univ Sci B 2005;6(4):227–31.</mixed-citation><mixed-citation xml:lang="ru">Yu J.K., Zheng S., Tang Y., Li L. An integrated approach utilizing proteomics and bioinformatics to detect ovarian cancer. J Zhejiang Univ Sci B 2005;6(4):227–31.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Zhang H., Kong B., Qu X. et al. Biomarker discovery for ovarian cancer using SELDI-TOF-MS. Gynecol Oncol 2006;102(1):61–6.</mixed-citation><mixed-citation xml:lang="ru">Zhang H., Kong B., Qu X. et al. Biomarker discovery for ovarian cancer using SELDI-TOF-MS. Gynecol Oncol 2006;102(1):61–6.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Helleman J., van der Vlies D., Jansen M.P. et al. Serum proteomic patterns for ovarian cancer monitoring. Int J Gynecol Cancer 2008;18(5):985–95.</mixed-citation><mixed-citation xml:lang="ru">Helleman J., van der Vlies D., Jansen M.P. et al. Serum proteomic patterns for ovarian cancer monitoring. Int J Gynecol Cancer 2008;18(5):985–95.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Lopez M.F., Mikulskis A., Kuzdzal S. et al. A novel, high-throughput workflow for discovery and identification of serum carrier protein-bound peptide biomarker candidates in ovarian cancer samples. Clin Chem 2007;53(6):1067–74.</mixed-citation><mixed-citation xml:lang="ru">Lopez M.F., Mikulskis A., Kuzdzal S. et al. A novel, high-throughput workflow for discovery and identification of serum carrier protein-bound peptide biomarker candidates in ovarian cancer samples. Clin Chem 2007;53(6):1067–74.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Jackson D., Craven R.A., Hutson R.C. et al. Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer. Clin Cancer Res 2007;13(24):7370–9.</mixed-citation><mixed-citation xml:lang="ru">Jackson D., Craven R.A., Hutson R.C. et al. Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer. Clin Cancer Res 2007;13(24):7370–9.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Moshkovskii S.A., Serebryakova M.V., Kuteykin-Teplyakov K.B. et al. Ovarian cancer marker of 11.7 kDa detected by proteomics is a serum amyloid A1. Proteomics 2005;5(14):3790–7.</mixed-citation><mixed-citation xml:lang="ru">Moshkovskii S.A., Serebryakova M.V., Kuteykin-Teplyakov K.B. et al. Ovarian cancer marker of 11.7 kDa detected by proteomics is a serum amyloid A1. Proteomics 2005;5(14):3790–7.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Lin Y.W., Lin C.Y., Lai H.C. et al. Plasma proteomic pattern as biomarkers for ovarian cancer. Int J Gynecol Cancer 2006;16(Suppl 1):139–46.</mixed-citation><mixed-citation xml:lang="ru">Lin Y.W., Lin C.Y., Lai H.C. et al. Plasma proteomic pattern as biomarkers for ovarian cancer. Int J Gynecol Cancer 2006;16(Suppl 1):139–46.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">41. Boylan K.L., Andersen J.D., Anderson L.B. et al. Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum. Proteome Sci 2010;8:31.</mixed-citation><mixed-citation xml:lang="ru">Boylan K.L., Andersen J.D., Anderson L.B. et al. Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum. Proteome Sci 2010;8:31.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">42. Kumar S., Tsai C.J., Nussinov R. Temperature range of thermodynamic stability for the native state of reversible two-state proteins. Biochemistry 2003;42(17):4864–73.</mixed-citation><mixed-citation xml:lang="ru">Kumar S., Tsai C.J., Nussinov R. Temperature range of thermodynamic stability for the native state of reversible two-state proteins. Biochemistry 2003;42(17):4864–73.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">43. Ye B., Skates S., Mok S.C. et al. Proteomic-based discovery and characterization of glycosylated eosinophil- derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin Cancer Res 2006;12(2):432–41.</mixed-citation><mixed-citation xml:lang="ru">Ye B., Skates S., Mok S.C. et al. Proteomic-based discovery and characterization of glycosylated eosinophil- derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin Cancer Res 2006;12(2):432–41.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">44. Petri A.L., Simonsen A.H., Yip T.T. et al. Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology. Acta Obstet Gynecol Scand 2009;88(1):18–26.</mixed-citation><mixed-citation xml:lang="ru">Petri A.L., Simonsen A.H., Yip T.T. et al. Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology. Acta Obstet Gynecol Scand 2009;88(1):18–26.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">45. Drenberg C.D., Saunders B.O., Wilbanks G.D. et al. Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer. Gynecol Oncol 2010;117(1):117–24.</mixed-citation><mixed-citation xml:lang="ru">Drenberg C.D., Saunders B.O., Wilbanks G.D. et al. Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer. Gynecol Oncol 2010;117(1):117–24.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">46. Adam R.A., Adam Y.G. Malignant ascites: past, present, and future. J Am Coll Surg 2004;198(6):999–1011.</mixed-citation><mixed-citation xml:lang="ru">Adam R.A., Adam Y.G. Malignant ascites: past, present, and future. J Am Coll Surg 2004;198(6):999–1011.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">47. Kassis J., Klominek J., Kohn E.C. Tumor microenvironment: what can effusions teach us? Diagn Cytopathol 2005;33(5):316–9.</mixed-citation><mixed-citation xml:lang="ru">Kassis J., Klominek J., Kohn E.C. Tumor microenvironment: what can effusions teach us? Diagn Cytopathol 2005;33(5):316–9.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">48. Tamsma J.T., Keizer H.J., Meinders A.E. Pathogenesis of malignant ascites: Starling’s law of capillary hemodynamics revisited. Ann Oncol 2001;12(10):1353–7.</mixed-citation><mixed-citation xml:lang="ru">Tamsma J.T., Keizer H.J., Meinders A.E. Pathogenesis of malignant ascites: Starling’s law of capillary hemodynamics revisited. Ann Oncol 2001;12(10):1353–7.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">49. Hu L., Hofmann J., Zaloudek C. et al. Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am J Pathol 2002;161(5):1917–24.</mixed-citation><mixed-citation xml:lang="ru">Hu L., Hofmann J., Zaloudek C. et al. Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am J Pathol 2002;161(5):1917–24.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">50. Berchuck A., Carney M. Human ovarian cancer of the surface epithelium. Biochem Pharmacol 1997;54(5):541–4.</mixed-citation><mixed-citation xml:lang="ru">Berchuck A., Carney M. Human ovarian cancer of the surface epithelium. Biochem Pharmacol 1997;54(5):541–4.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">51. Verheul H.M., Hoekman K., Jorna A.S. et al. Targeting vascular endothelial growth factor blockade: ascites and pleural effusion formation. Oncologist 2000;5(Suppl 1):45–50.</mixed-citation><mixed-citation xml:lang="ru">Verheul H.M., Hoekman K., Jorna A.S. et al. Targeting vascular endothelial growth factor blockade: ascites and pleural effusion formation. Oncologist 2000;5(Suppl 1):45–50.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">52. Gortzak-Uzan L., Ignatchenko A., Evangelou A.I. et al. A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers. J Proteome Res 2008;7(1):339–51.</mixed-citation><mixed-citation xml:lang="ru">Gortzak-Uzan L., Ignatchenko A., Evangelou A.I. et al. A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers. J Proteome Res 2008;7(1):339–51.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">53. Kuk C., Kulasingam V., Gunawardana C.G. et al. Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers. Mol Cell Proteomics 2009;8(4):661–9.</mixed-citation><mixed-citation xml:lang="ru">Kuk C., Kulasingam V., Gunawardana C.G. et al. Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers. Mol Cell Proteomics 2009;8(4):661–9.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">54. Davidson B., Espina V., Steinberg S.M. et al. Proteomic analysis of malignant ovarian cancer effusions as a tool for biologic and prognostic profiling. Clin Cancer Res 2006;12(3 Pt 1):791–9.</mixed-citation><mixed-citation xml:lang="ru">Davidson B., Espina V., Steinberg S.M. et al. Proteomic analysis of malignant ovarian cancer effusions as a tool for biologic and prognostic profiling. Clin Cancer Res 2006;12(3 Pt 1):791–9.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">55. Amon L.M., Law W., Fitzgibbon M.P. et al. Integrative proteomic analysis of serum and peritoneal fluids helps identify proteins that are up-regulated in serum of women with ovarian cancer. PLoS One 2010;5(6):11137.</mixed-citation><mixed-citation xml:lang="ru">Amon L.M., Law W., Fitzgibbon M.P. et al. Integrative proteomic analysis of serum and peritoneal fluids helps identify proteins that are up-regulated in serum of women with ovarian cancer. PLoS One 2010;5(6):11137.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">56. Wang H., Kachman M.T., Schwartz D.R. et al. A protein molecular weight map of ES2 clear cell ovarian carcinoma cells using a two-dimensional liquid separations/ mass mapping technique. Electrophoresis 2002;23(18):3168–81.</mixed-citation><mixed-citation xml:lang="ru">Wang H., Kachman M.T., Schwartz D.R. et al. A protein molecular weight map of ES2 clear cell ovarian carcinoma cells using a two-dimensional liquid separations/ mass mapping technique. Electrophoresis 2002;23(18):3168–81.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">57. Wang H., Kachman M.T., Schwartz D.R. et al. Comprehensive proteome analysis of ovarian cancers using liquid phase separation, mass mapping and tandem mass spectrometry: a strategy for identification of candidate cancer biomarkers. Proteomics 2004;4(8):2476–95.</mixed-citation><mixed-citation xml:lang="ru">Wang H., Kachman M.T., Schwartz D.R. et al. Comprehensive proteome analysis of ovarian cancers using liquid phase separation, mass mapping and tandem mass spectrometry: a strategy for identification of candidate cancer biomarkers. Proteomics 2004;4(8):2476–95.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">58. Gagne J.P., Ethier C., Gagne P. et al. Comparative proteome analysis of human epithelial ovarian cancer. Proteome Sci 2007;5:16.</mixed-citation><mixed-citation xml:lang="ru">Gagne J.P., Ethier C., Gagne P. et al. Comparative proteome analysis of human epithelial ovarian cancer. Proteome Sci 2007;5:16.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">59. He Q.Y., Zhou Y., Wong E. et al. Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies. Gynecol Oncol 2005;98(1):68–76.</mixed-citation><mixed-citation xml:lang="ru">He Q.Y., Zhou Y., Wong E. et al. Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies. Gynecol Oncol 2005;98(1):68–76.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">60. Yan X.D., Pan L.Y., Yuan Y. et al. Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines. J Proteome Res 2007;6(2):772–80.</mixed-citation><mixed-citation xml:lang="ru">Yan X.D., Pan L.Y., Yuan Y. et al. Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines. J Proteome Res 2007;6(2):772–80.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">61. Stewart J.J., White J.T., Yan X. et al. Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels. Mol Cell Proteom 2006;5(3):433–43.</mixed-citation><mixed-citation xml:lang="ru">Stewart J.J., White J.T., Yan X. et al. Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels. Mol Cell Proteom 2006;5(3):433–43.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">62. Chien J., Aletti G., Baldi A. et al. Serine protease HtrA1 modulates chemotherapy- induced cytotoxicity. J Clin Invest 2006;116(7):1994–2004.</mixed-citation><mixed-citation xml:lang="ru">Chien J., Aletti G., Baldi A. et al. Serine protease HtrA1 modulates chemotherapy- induced cytotoxicity. J Clin Invest 2006;116(7):1994–2004.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">63. Le Moguen K., Lincet H., Deslandes E. et al. Comparative proteomic analysis of cisplatin sensitive IGROV1 ovarian carcinoma cell line and its resistant counterpart IGROV1-R10. Proteomics 2006;6(19):5183–92.</mixed-citation><mixed-citation xml:lang="ru">Le Moguen K., Lincet H., Deslandes E. et al. Comparative proteomic analysis of cisplatin sensitive IGROV1 ovarian carcinoma cell line and its resistant counterpart IGROV1-R10. Proteomics 2006;6(19):5183–92.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">64. Song J., Shih Ie M., Salani R. et al. Annexin XI is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients. Clin Cancer Res 2007;13(22 Pt 1):6842–9.</mixed-citation><mixed-citation xml:lang="ru">Song J., Shih Ie M., Salani R. et al. Annexin XI is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients. Clin Cancer Res 2007;13(22 Pt 1):6842–9.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">65. Tian Y., Tan A.C., Sun X. et al. Quantitative proteomic analysis of ovarian cancer cells identified mitochondrial proteins associated with paclitaxel resistance. Proteom Clin Appl 2009;3(11):1288–95.</mixed-citation><mixed-citation xml:lang="ru">Tian Y., Tan A.C., Sun X. et al. Quantitative proteomic analysis of ovarian cancer cells identified mitochondrial proteins associated with paclitaxel resistance. Proteom Clin Appl 2009;3(11):1288–95.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">66. Emmert-Buck M.R., Bonner R.F., Smith P.D. et al. Laser capture microdissection. Science 1996;274(5289):998–1001.</mixed-citation><mixed-citation xml:lang="ru">Emmert-Buck M.R., Bonner R.F., Smith P.D. et al. Laser capture microdissection. Science 1996;274(5289):998–1001.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">67. Banks R.E., Dunn M.J., Forbes M.A. et al. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis — preliminary findings. Electrophoresis 1999;20(4–5):689–700.</mixed-citation><mixed-citation xml:lang="ru">Banks R.E., Dunn M.J., Forbes M.A. et al. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis — preliminary findings. Electrophoresis 1999;20(4–5):689–700.</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><citation-alternatives><mixed-citation xml:lang="en">68. Ornstein D.K., Gillespie J.W., Paweletz C.P. et al. Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines. Electrophoresis 2000;21(11):2235–42.</mixed-citation><mixed-citation xml:lang="ru">Ornstein D.K., Gillespie J.W., Paweletz C.P. et al. Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines. Electrophoresis 2000;21(11):2235–42.</mixed-citation></citation-alternatives></ref><ref id="B69"><label>69.</label><citation-alternatives><mixed-citation xml:lang="en">69. Cazares L.H., Adam B.L., Ward M.D. et al. Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization</mixed-citation><mixed-citation xml:lang="ru">Cazares L.H., Adam B.L., Ward M.D. et al. Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization</mixed-citation></citation-alternatives></ref><ref id="B70"><label>70.</label><mixed-citation>mass spectrometry. Clin Cancer Res 2002;8(8):2541–52.</mixed-citation></ref><ref id="B71"><label>71.</label><citation-alternatives><mixed-citation xml:lang="en">70. Shekouh A.R., Thompson C.C., Prime W. et al. Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics 2003;3(10):1988–2001.</mixed-citation><mixed-citation xml:lang="ru">Shekouh A.R., Thompson C.C., Prime W. et al. Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics 2003;3(10):1988–2001.</mixed-citation></citation-alternatives></ref><ref id="B72"><label>72.</label><citation-alternatives><mixed-citation xml:lang="en">71. Melle C., Ernst G., Schimmel B. et al. A technical triade for proteomic identification and characterization of cancer biomarkers. Cancer Res 2004;64(12):4099–104.</mixed-citation><mixed-citation xml:lang="ru">Melle C., Ernst G., Schimmel B. et al. A technical triade for proteomic identification and characterization of cancer biomarkers. Cancer Res 2004;64(12):4099–104.</mixed-citation></citation-alternatives></ref><ref id="B73"><label>73.</label><citation-alternatives><mixed-citation xml:lang="en">72. Lawrie L.C., Curran S., McLeod H.L. et al. Application of laser capture microdissection and proteomics in colon cancer. Mol Pathol 2001;54(4):253–8.</mixed-citation><mixed-citation xml:lang="ru">Lawrie L.C., Curran S., McLeod H.L. et al. Application of laser capture microdissection and proteomics in colon cancer. Mol Pathol 2001;54(4):253–8.</mixed-citation></citation-alternatives></ref><ref id="B74"><label>74.</label><citation-alternatives><mixed-citation xml:lang="en">73. Cadron I., Van Gorp T., Amant F. et al. The use of laser microdissection and SELDI-TOF MS in ovarian cancer tissue to identify protein profiles. Anticancer Res 2009;29(4):1039–45.</mixed-citation><mixed-citation xml:lang="ru">Cadron I., Van Gorp T., Amant F. et al. The use of laser microdissection and SELDI-TOF MS in ovarian cancer tissue to identify protein profiles. Anticancer Res 2009;29(4):1039–45.</mixed-citation></citation-alternatives></ref><ref id="B75"><label>75.</label><citation-alternatives><mixed-citation xml:lang="en">74. Wang W., Guo T., Rudnick P.A. et al. Membrane proteome analysis of microdissected ovarian tumor tissues using capillary isoelectric focusing/reversed-phase liquid chromatography-tandem MS. Anal Chem 2007;79(3):1002–9.</mixed-citation><mixed-citation xml:lang="ru">Wang W., Guo T., Rudnick P.A. et al. Membrane proteome analysis of microdissected ovarian tumor tissues using capillary isoelectric focusing/reversed-phase liquid chromatography-tandem MS. Anal Chem 2007;79(3):1002–9.</mixed-citation></citation-alternatives></ref><ref id="B76"><label>76.</label><citation-alternatives><mixed-citation xml:lang="en">75. Jones M.B., Krutzsch H., Shu H. et al. Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics 2002;2(1):76–84.</mixed-citation><mixed-citation xml:lang="ru">Jones M.B., Krutzsch H., Shu H. et al. Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics 2002;2(1):76–84.</mixed-citation></citation-alternatives></ref><ref id="B77"><label>77.</label><citation-alternatives><mixed-citation xml:lang="en">76. An H.J., Kim D.S., Park Y.K. et al. Comparative proteomics of ovarian epithelial tumors. J Proteom Res 2006;5(5):1082–90.</mixed-citation><mixed-citation xml:lang="ru">An H.J., Kim D.S., Park Y.K. et al. Comparative proteomics of ovarian epithelial tumors. J Proteom Res 2006;5(5):1082–90.</mixed-citation></citation-alternatives></ref><ref id="B78"><label>78.</label><citation-alternatives><mixed-citation xml:lang="en">77. Luo J., Qian J.H., Yu J.K. et al. Discovery of altered protein profiles in epithelial ovarian carcinogenesis by SELDI mass spectrometry. Eur J Gynaecol Oncol 2008;29(3):233–8.</mixed-citation><mixed-citation xml:lang="ru">Luo J., Qian J.H., Yu J.K. et al. Discovery of altered protein profiles in epithelial ovarian carcinogenesis by SELDI mass spectrometry. Eur J Gynaecol Oncol 2008;29(3):233–8.</mixed-citation></citation-alternatives></ref><ref id="B79"><label>79.</label><citation-alternatives><mixed-citation xml:lang="en">78. Bengtsson S., Krogh M., Szigyarto C.A. et al. Large-scale proteomics analysis of human ovarian cancer for biomarkers. J Proteome Res 2007;6(4):1440–50.</mixed-citation><mixed-citation xml:lang="ru">Bengtsson S., Krogh M., Szigyarto C.A. et al. Large-scale proteomics analysis of human ovarian cancer for biomarkers. J Proteome Res 2007;6(4):1440–50.</mixed-citation></citation-alternatives></ref><ref id="B80"><label>80.</label><citation-alternatives><mixed-citation xml:lang="en">79. Li X.Q., Zhang S.L., Cai Z. et al. Proteomic identification of tumor-associated protein in ovarian serous cystadenocarinoma. Cancer Lett 2009;275(1):109–16.</mixed-citation><mixed-citation xml:lang="ru">Li X.Q., Zhang S.L., Cai Z. et al. Proteomic identification of tumor-associated protein in ovarian serous cystadenocarinoma. Cancer Lett 2009;275(1):109–16.</mixed-citation></citation-alternatives></ref><ref id="B81"><label>81.</label><citation-alternatives><mixed-citation xml:lang="en">80. Cable S., Keller J.M., Colin S. et al. Peroxisomes in human colon carcinomas. A cytochemical and biochemical study. Virchows Arch B Cell Pathol Incl Mol Pathol 1992;62(4):221–6.</mixed-citation><mixed-citation xml:lang="ru">Cable S., Keller J.M., Colin S. et al. Peroxisomes in human colon carcinomas. A cytochemical and biochemical study. Virchows Arch B Cell Pathol Incl Mol Pathol 1992;62(4):221–6.</mixed-citation></citation-alternatives></ref><ref id="B82"><label>82.</label><citation-alternatives><mixed-citation xml:lang="en">81. Suto K., Kajihara-Kano H., Yokoyama Y. et al. Decreased expression of the peroxisomal bifunctional enzyme and carbonyl reductase in human hepatocellular carcinomas. J Cancer Res Clin Oncol 1999;125(2):83–8.</mixed-citation><mixed-citation xml:lang="ru">Suto K., Kajihara-Kano H., Yokoyama Y. et al. Decreased expression of the peroxisomal bifunctional enzyme and carbonyl reductase in human hepatocellular carcinomas. J Cancer Res Clin Oncol 1999;125(2):83–8.</mixed-citation></citation-alternatives></ref><ref id="B83"><label>83.</label><citation-alternatives><mixed-citation xml:lang="en">82. Faratian D., Um I., Wilson D.S. et al. Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy. Eur J Cancer 2011.</mixed-citation><mixed-citation xml:lang="ru">Faratian D., Um I., Wilson D.S. et al. Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy. Eur J Cancer 2011.</mixed-citation></citation-alternatives></ref><ref id="B84"><label>84.</label><citation-alternatives><mixed-citation xml:lang="en">83. El Ayed M., Bonnel D., Longuespee R. et al. MALDI imaging mass spectrometry in ovarian cancer for tracking, identifying, and validating biomarkers. Med Sci Monit 2010;16(8):233–45.</mixed-citation><mixed-citation xml:lang="ru">El Ayed M., Bonnel D., Longuespee R. et al. MALDI imaging mass spectrometry in ovarian cancer for tracking, identifying, and validating biomarkers. Med Sci Monit 2010;16(8):233–45.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
