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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">178</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2011-0-3-56-64</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. PROBLEM</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ПРОБЛЕМА</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Early ovarian cancer: our view of the problem</article-title><trans-title-group xml:lang="ru"><trans-title>Ранний рак яичников: наш взгляд на проблему</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhordania</surname><given-names>K. I.</given-names></name><name xml:lang="ru"><surname>Жорданиа</surname><given-names>К. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khokhlova</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Хохлова</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>svkhokhlova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Cancerogenesis Research Institute, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">НИИ клинической онкологии РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-08-14" publication-format="electronic"><day>14</day><month>08</month><year>2011</year></pub-date><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>56</fpage><lpage>64</lpage><history><date date-type="received" iso-8601-date="2014-08-18"><day>18</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-18"><day>18</day><month>08</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/178">https://ojrs.abvpress.ru/ojrs/article/view/178</self-uri><abstract xml:lang="en"><p>The paper considers some pathogenetic aspects of ovarian tumor development, on the basis of which the authors recommend to perform more aggressive chemotherapy in patients with the so-called early stages of ovarian cancer.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассматриваются некоторые патогенетические аспекты развития опухолей яичников, на основании которых авторы рекомендуют проводить более агрессивную химиотерапию больным, страдающим так называемыми ранними стадиями рака яичников.</p></trans-abstract><kwd-group xml:lang="en"><kwd>early ovarian cancer</kwd><kwd>pathogenesis</kwd><kwd>metastases</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ранний рак яичников</kwd><kwd>патогенез</kwd><kwd>метастазы</kwd><kwd>лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2006 г. Вестн РОНЦ им. Н.Н. Блохина РАМН 2008;19(2 Прил 1).</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2006 г. Вестн РОНЦ им. Н.Н. Блохина РАМН 2008;19(2 Прил 1).</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Карселадзе А.И. Морфология эпителиальных опухолей яичников. Автореф. дис. ... д-ра мед. наук. М., 1989.</mixed-citation><mixed-citation xml:lang="ru">Карселадзе А.И. Морфология эпителиальных опухолей яичников. Автореф. дис. ... д-ра мед. наук. М., 1989.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Kindelberger D.W, Lee Y., Miron A. et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 2007;31:161–9.</mixed-citation><mixed-citation xml:lang="ru">Kindelberger D.W, Lee Y., Miron A. et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 2007;31:161–9.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Глазунов М.Ф. Опухоли яичников. Л., 1961.</mixed-citation><mixed-citation xml:lang="ru">Глазунов М.Ф. Опухоли яичников. Л., 1961.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Прокопенко П.Г., Борисенко С.А., Полторанина В.С. и др. Опухоли яичников: особенности эволюции, распространения, диагностики и профилактики. ОЖРС 2011;(1):63–9.</mixed-citation><mixed-citation xml:lang="ru">Прокопенко П.Г., Борисенко С.А., Полторанина В.С. и др. Опухоли яичников: особенности эволюции, распространения, диагностики и профилактики. ОЖРС 2011;(1):63–9.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Cliby W.A., Aletty G.D. et al. Is it justified to classify patients to stage IIIC epithelial ovarian cancer based on nodal involvement only? Gynecol Oncol 2006;12(103):797–801.</mixed-citation><mixed-citation xml:lang="ru">Cliby W.A., Aletty G.D. et al. Is it justified to classify patients to stage IIIC epithelial ovarian cancer based on nodal involvement only? Gynecol Oncol 2006;12(103):797–801.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Piver M.S., Marchetti D.L. Potential for cure in ovarian cancer. Comp Ther 1986; 12:13–20.</mixed-citation><mixed-citation xml:lang="ru">Piver M.S., Marchetti D.L. Potential for cure in ovarian cancer. Comp Ther 1986; 12:13–20.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Faber A.N., Rose P.G. Роль хирургии в лечении рака яичников. J Clin Oncol 2007;1(4):331–41.</mixed-citation><mixed-citation xml:lang="ru">Faber A.N., Rose P.G. Роль хирургии в лечении рака яичников. J Clin Oncol 2007;1(4):331–41.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Janni W. et al. Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse – a European pooled analysis. Düsseldorf: Frauenklinik der Heinrich- Heine-Universitat.</mixed-citation><mixed-citation xml:lang="ru">Janni W. et al. Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse – a European pooled analysis. Düsseldorf: Frauenklinik der Heinrich- Heine-Universitat.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Braun S et al. Occult tumor cells in bone marrow of patients with locoregionally restricted ovarian cancer predict early distant metastatic relapse. J Clin Oncol 2001;19(2):368–75.</mixed-citation><mixed-citation xml:lang="ru">Braun S et al. Occult tumor cells in bone marrow of patients with locoregionally restricted ovarian cancer predict early distant metastatic relapse. J Clin Oncol 2001;19(2):368–75.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Kaplan R.N., Riba R.D., Zacharoulis S. et al. VEGFR1 – positive haematopoetic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;8:(438):820–7.</mixed-citation><mixed-citation xml:lang="ru">Kaplan R.N., Riba R.D., Zacharoulis S. et al. VEGFR1 – positive haematopoetic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;8:(438):820–7.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Maffini M.V., Soto A.M., Callabro J.M. et al. The stroma as a crucial target in rat mammary gland carcinogenesis. J Cell Sci 2004;117:1495–502.</mixed-citation><mixed-citation xml:lang="ru">Maffini M.V., Soto A.M., Callabro J.M. et al. The stroma as a crucial target in rat mammary gland carcinogenesis. J Cell Sci 2004;117:1495–502.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Buys S.S., Partridge E., Black A. et al. Effect of screening on ovarian cancer mortality in the prostate, lung, color- ectal,ovarian cancer randomized screening trial. ASCO, 2011; abstr 5001.</mixed-citation><mixed-citation xml:lang="ru">Buys S.S., Partridge E., Black A. et al. Effect of screening on ovarian cancer mortality in the prostate, lung, color- ectal,ovarian cancer randomized screening trial. ASCO, 2011; abstr 5001.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Тамаева З.Э. Рецидивы рака яичника I–IIА стадии. Факторы прогноза, лечение. Автореф. дис. ... канд. мед. наук. М., 2005.</mixed-citation><mixed-citation xml:lang="ru">Тамаева З.Э. Рецидивы рака яичника I–IIА стадии. Факторы прогноза, лечение. Автореф. дис. ... канд. мед. наук. М., 2005.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Минимальные клинические рекомендации Европейского общества медицинской онкологии. Под ред. С.А. Тюляндина, Н.И. Переводчиковой, Д.А. Носова. М.: РОНЦ им. Н.Н. Блохина РАМН, 2007;с. 331–41.</mixed-citation><mixed-citation xml:lang="ru">Минимальные клинические рекомендации Европейского общества медицинской онкологии. Под ред. С.А. Тюляндина, Н.И. Переводчиковой, Д.А. Носова. М.: РОНЦ им. Н.Н. Блохина РАМН, 2007;с. 331–41.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Benedetti-Panici B., Maggioni A., Hacker N. et al. Systematic aortic and pelvic lymphadenectomy versus resection of bulky nodes only in optimally debulked advanced ovarian cancer: a randomized clinical trial. J Natl Cancer Inst 2005;97:560–6.</mixed-citation><mixed-citation xml:lang="ru">Benedetti-Panici B., Maggioni A., Hacker N. et al. Systematic aortic and pelvic lymphadenectomy versus resection of bulky nodes only in optimally debulked advanced ovarian cancer: a randomized clinical trial. J Natl Cancer Inst 2005;97:560–6.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Kim H., Ju W. et al. The efficacy of systemic lymphadenectomy for overal survival in epithelial ovarian cancer: a systematic review and meta-analysis by KOGYMAG. J Clin Oncol 2009;27; abstr 16509.</mixed-citation><mixed-citation xml:lang="ru">Kim H., Ju W. et al. The efficacy of systemic lymphadenectomy for overal survival in epithelial ovarian cancer: a systematic review and meta-analysis by KOGYMAG. J Clin Oncol 2009;27; abstr 16509.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Hoskins W.J., McGuire W.P., Brady M.F. et al. The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma. Am J Obstet Gynecol 1994;170(4):974–80.</mixed-citation><mixed-citation xml:lang="ru">Hoskins W.J., McGuire W.P., Brady M.F. et al. The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma. Am J Obstet Gynecol 1994;170(4):974–80.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Skirnisdottir I., Sorbe B. et al. Survival and prognostic factors in early-stage epithelial ovarian cancer treated with taxane-based adjuvant chemotherapy. Intern J Gynecol Cancer 2007.</mixed-citation><mixed-citation xml:lang="ru">Skirnisdottir I., Sorbe B. et al. Survival and prognostic factors in early-stage epithelial ovarian cancer treated with taxane-based adjuvant chemotherapy. Intern J Gynecol Cancer 2007.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Barrum-Gamez J. et al. Is there a high- risk subgroup of stage 1 of epithelial ovarian carcinoma that is most likely to benefit from 6 versus 3 cycles of adjuvant chemotherapy? Intern J Gynecol Cancer 2010;20(7).</mixed-citation><mixed-citation xml:lang="ru">Barrum-Gamez J. et al. Is there a high- risk subgroup of stage 1 of epithelial ovarian carcinoma that is most likely to benefit from 6 versus 3 cycles of adjuvant chemotherapy? Intern J Gynecol Cancer 2010;20(7).</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Winter-Roach B., Hooper L., Kitchener H. Systematic review of adjuvant therapy for early stage (epithelial) ovarian cancer. Intern J Gynecol Cancer 2003; 13(4):395–404.</mixed-citation><mixed-citation xml:lang="ru">Winter-Roach B., Hooper L., Kitchener H. Systematic review of adjuvant therapy for early stage (epithelial) ovarian cancer. Intern J Gynecol Cancer 2003; 13(4):395–404.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
