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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">191</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2011-0-4-24-27</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. PROBLEM</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ПРОБЛЕМА</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The specific features of T cell immunity in breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности Т-клеточного иммунитета при раке молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skotarenko</surname><given-names>L. V.</given-names></name><name xml:lang="ru"><surname>Скотаренко</surname><given-names>Л. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>remrem84@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vorotnikov</surname><given-names>I. K.</given-names></name><name xml:lang="ru"><surname>Воротников</surname><given-names>И. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kadagidze</surname><given-names>Z. G.</given-names></name><name xml:lang="ru"><surname>Кадагидзе</surname><given-names>З. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamilov</surname><given-names>F. A.</given-names></name><name xml:lang="ru"><surname>Шамилов</surname><given-names>Ф. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ФГБУ РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-11-18" publication-format="electronic"><day>18</day><month>11</month><year>2011</year></pub-date><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>24</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2014-08-20"><day>20</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-20"><day>20</day><month>08</month><year>2014</year></date></history><permissions><copyright-year>2011</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/191">https://ojrs.abvpress.ru/ojrs/article/view/191</self-uri><abstract xml:lang="en"><p>The fact that the formation and growth of malignancies occur with pronounced immune impairments is beyond question now. In the past de- cades, great progress has been made in the studies of the immunology and immunotherapy of malignancies, including breast cancer. Despite intensive studies of the specific features of cell immunity in breast cancer, many points remain to be inadequately studied sofar and the avail- able information is controversial and scarce, which calls for further studies.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время не вызывает сомнений тот факт, что формирование и рост злокачественных новообразований происходят на фоне выраженных нарушений иммунной системы. За последние десятилетия достигнуты большие успехи в исследовании иммунологии и иммунотерапии злокачественных опухолей, в том числе рака молочной железы. Несмотря на активное исследование особенностей клеточного иммунитета при раке молочной железы, многие детали пока остаются недостаточно изученными, а имеющаяся информация — спорной и немногочисленной, что и диктует необходимость дальнейшего изучения этой проблемы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>antitumor immunity</kwd><kwd>Treg cells</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>противоопухолевый иммунитет</kwd><kwd>Treg-клетки</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Seino K., Motohashi S., Fujisawa T. et al. Natural killer T cell-mediated antitumor immune responses and their clinical applications. Cancer Sci 2006;97:807–12.</mixed-citation><mixed-citation xml:lang="ru">Seino K., Motohashi S., Fujisawa T. et al. 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