Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press20210.17650/1994-4098-2011-0-4-72-75GYNECOLOGY. PROBLEMГИНЕКОЛОГИЯ. ПРОБЛЕМАAnalysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteriАнализ экспрессии генов пролиферации и апоптоза при цервикальных интраэпителиальных неоплазиях и раке шейки маткиBozhenkoV. K.БоженкоВ. К.
Russian Federation
AshrafyanL. A.АшрафянЛ. А.AntonovaI. B.АнтоноваИ. Б.MelnikovaN. V.МельниковаН. В.BurmenskayaO. N.БурменскаяО. Н.TrofimovD. Yu.ТрофимовД. Ю.KudinovaE. A.КудиноваЕ. А.KhunovaL. Z.ХуноваЛ. З.khunova@mail.ruSlonovA. V.СлоновА. В.BliznyukovO. P.БлизнюковО. П.Russian X-Ray Radiology Research Center, Ministry of Health and Social Development of RussiaФГУ РНЦРР Минздравсоцразвития РоссииOAO DNA-Technology, MoscowОАО ДНК-технология, Москва181120114727521082014210820142011https://ojrs.abvpress.ru/ojrs/article/view/202

The viral nature of many female genital cancers is now beyond question. By taking into account this fact, the problem of qualitative assessment ofthenatureofcervicalintraepithelialneoplasia(CIN)anditsfocusonprogressiontoinvasivecarcinomabecomesquitenatu ral.Studiesof a number of biological markers of carcinogenesis have recently provided a possibility for prospective prediction. The paper con siders the as- pects of importance of the molecular biological markers of proliferation and apoptosis in the etiopathogenesis of genital cancers. It gives the results of examinations of 16 patients with histologically verified squamous cell carcinoma of the cervix uteri, 40 patients di agnosed as having CIN of different grades (CIN-1, CIN-2, CIN-3 — squamous cell carcinoma in situ), and 6 patients with the morphologically unaltered cervi- calepithelium,whosecervicalscrapeswereanalyzedfortheexpressionofthemRNAgenesССNB1,Ki-67,BA G,BCL-2,ESR1,andPRG. It is shown that the molecular genetic findings may be new prognostic markers that reflect the possible disease developmental pathways, sug- gesting the need for further investigation of biomarkers in order to prevent malignancies and to reduce their morbidity.

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