Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press21910.17650/1994-4098-2010-0-1-63-67GYNECOLOGY. DIAGNOSISГИНЕКОЛОГИЯ. ДИАГНОСТИКАSpecific features of the clinical picture, diagnosis, and treatment of trophoblastic tumor of the placental bedОсобенности клиники, диагностики
 и лечения трофобластической
 опухоли плацентарного ложаLisaevD. A.ЛисаевД. А.
Russian Federation
Lisaev84@mail.ruToloknovB. O.ТолокновБ. О.
Russian Federation
MakhovaE. E.МаховаЕ. Е.
Russian Federation
ZakharovaT. I.ЗахароваТ. И.
Russian Federation
MarkinaI. V.МаркинаИ. В.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesГУ РОНЦ им. Н.Н. Блохина РАМН, МоскваDepartment of Oncology, Moscow State University of Medicine and Dentistryкафедра онкологии ФПДО МГМСУ250220101636725082014250820142010https://ojrs.abvpress.ru/ojrs/article/view/219

Trophoblastic tumor of the placental bed is a highly malignant form of trophoblastic disease that occurs extremely rarely: 0.4-2% of all the trophoblastic tumors. In the world literature, there are reports on about 200 cases of this disease. The tumor occurs at a repro- ductive age (median age 30 years), occasionally even long after pregnancy, which makes the problem of diagnosis and treatment of the pathology particularly pressing. In 30% of cases, there are metastases more frequently to the lung and vagina. The diagnostic features of a placental bed tumor include the low serum levels of chorionic gonadotropin β-subunits and the higher level of human placental lactogen. Due to low tumor susceptibility to chemotherapy, the patients should undergo surgical intervention as uterine extirpation at the first treatment stage, which is followed by chemotherapy.

Трофобластическая опухоль плацентарного ложа — высоко-злокачественная форма трофобластической болезни, которая встречается крайне редко: 0,4—2% всех трофобластических опухолей. В мировой литературе опубликованы данные всего около 200 наблюдений этого заболевания. Опухоль возникает в репродуктивном возрасте (средний возраст — 30 лет), иногда даже спустя длительное время после беременности, что делает проблему диагностики и лечения патологии особенно актуальной. Метастазы наблюдаются в 30% случаев, чаще в легкие и влагалище. К особенностям диагностики опухоли плацентарного ложа относятся невысокие уровни β-субъединиц хориогонического гонадотропина в сыворотке крови и повышение уровня человеческого плацентарного лактогена. В связи с низкой чувствительностью опухоли к химиотерапии на первом этапе лечения пациентки подвергаются оперативному вмешательству в объеме экстирпации матки с последующей химиотерапией.

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