<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">22</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2014-0-2-23-29</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ЛЕЧЕНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Radiotherapy following organ-sparing surgery for breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Лучевая терапия после органосохраняющих операций на молочной железе</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gladilina</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Гладилина</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>0152@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nechushkin</surname><given-names>M. I.</given-names></name><name xml:lang="ru"><surname>Нечушкин</surname><given-names>М. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Uimanov</surname><given-names>V. А.</given-names></name><name xml:lang="ru"><surname>Уйманов</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vysotskaya</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Высоцкая</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chernykh</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Черных</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yegorova</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Егорова</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chulkova</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Чулкова</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff6"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва</institution></aff></aff-alternatives><aff id="aff6"><institution>N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow</institution></aff><pub-date date-type="pub" iso-8601-date="2014-07-17" publication-format="electronic"><day>17</day><month>07</month><year>2014</year></pub-date><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>23</fpage><lpage>29</lpage><history><date date-type="received" iso-8601-date="2014-07-18"><day>18</day><month>07</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-07-18"><day>18</day><month>07</month><year>2014</year></date></history><permissions/><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/22">https://ojrs.abvpress.ru/ojrs/article/view/22</self-uri><abstract xml:lang="en"><p>The paper gives a major update on the most optimal use of radiotherapy following breast-sparing surgery. It discusses indications for and contraindications to the technique in different age categories and in different prognostic factors.</p></abstract><trans-abstract xml:lang="ru"><p>В статье приводятся основные современные данные, касающиеся наиболее оптимального применения лучевой терапии после ор- ганосохраняющих операций на молочной железе. Обсуждаются показания и противопоказания использования метода в различных возрастных категориях, а также при различных прогностических факторах.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>radiotherapy</kwd><kwd>organ-saving surgery</kwd><kwd>brachytherapy</kwd><kwd>removed tumor bed</kwd><kwd>conformal radiation therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>лучевая терапия</kwd><kwd>органосохраняющие операции</kwd><kwd>брахитерапия</kwd><kwd>ложе удаленной опухоли</kwd><kwd>конформная лучевая терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Arriagada R., Lê M.G., Rochard F., Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns</mixed-citation><mixed-citation xml:lang="ru">Arriagada R., Lê M.G., Rochard F., Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol 1996;14(15):1558–64.</mixed-citation></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">2. Clark R.M., McCulloch P.B., Levine M.N. et al. Randomized clinical trial to assess</mixed-citation><mixed-citation xml:lang="ru">Clark R.M., McCulloch P.B., Levine M.N. et al. Randomized clinical trial to assess</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><mixed-citation>the effectiveness of breast irradiation following lumpectomy and axillary dissection for node- negative breast cancer J Natl Cancer Inst 1992;84(9):683–9.</mixed-citation></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">3. Fisher B., Anderson S., Bryant J. et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347(8):1233–41.</mixed-citation><mixed-citation xml:lang="ru">Fisher B., Anderson S., Bryant J. et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347(8):1233–41.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">4. Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.</mixed-citation><mixed-citation xml:lang="ru">Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><mixed-citation>N Engl J Med 2002;347(16):1227–32.</mixed-citation></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">5. Клиническая онкология. Под ред. Н.Н. Блохина, Б.Е. Петерсона. 2-е изд. М.: Медицина, 1979.</mixed-citation><mixed-citation xml:lang="ru">Клиническая онкология. Под ред. Н.Н. Блохина, Б.Е. Петерсона. 2-е изд. М.: Медицина, 1979.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">6. Вишнякова В.В. Эффективность эко- номных операций при раке молочной железы. Вопр онкол 1990;36(5):540–5.</mixed-citation><mixed-citation xml:lang="ru">Вишнякова В.В. Эффективность эко- номных операций при раке молочной железы. Вопр онкол 1990;36(5):540–5.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">7. Практическое руководство по клиниче- ской маммологии. Под ред. М.И. Давыдо- ва, В.П. Летягина. М., 2004. С. 59–62.</mixed-citation><mixed-citation xml:lang="ru">Практическое руководство по клиниче- ской маммологии. Под ред. М.И. Давыдо- ва, В.П. Летягина. М., 2004. С. 59–62.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">8. Давыдов М.И., Летягин В.П. Семинар по клинической маммологии. М., 2006. С. 59–63.</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Летягин В.П. Семинар по клинической маммологии. М., 2006. С. 59–63.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">9. Высоцкая И.В., Кушлинский Н.Е., Погодина Е.М. и др. Практическая маммо- логия. Под ред. М.И. Давыдова, В.П. Летягина. М., 2007. 272 с.</mixed-citation><mixed-citation xml:lang="ru">Высоцкая И.В., Кушлинский Н.Е., Погодина Е.М. и др. Практическая маммо- логия. Под ред. М.И. Давыдова, В.П. Летягина. М., 2007. 272 с.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">10. Первичные опухоли молочной железы. Практическое руководство по лечению. Под ред. В.П. Летягина. М., 2004. 330 с.</mixed-citation><mixed-citation xml:lang="ru">Первичные опухоли молочной железы. Практическое руководство по лечению. Под ред. В.П. Летягина. М., 2004. 330 с.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">11. Gilligan M.A., Kneusel R.T., Hoffmann R.G. Persistent differences in sociodemographic determinants of breast conserving treatment despite overall increased adoption. Med Care 2005;40(3):181–9.</mixed-citation><mixed-citation xml:lang="ru">Gilligan M.A., Kneusel R.T., Hoffmann R.G. Persistent differences in sociodemographic determinants of breast conserving treatment despite overall increased adoption. Med Care 2005;40(3):181–9.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">12. Johansson S., Svensson H., Denekamp J. Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys 2000;48(3):745–50.</mixed-citation><mixed-citation xml:lang="ru">Johansson S., Svensson H., Denekamp J. Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys 2000;48(3):745–50.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">13. Veronesi U., Luini A., Del Vecchio M. et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med 1993;328(22):1587–91. 14. Antonini N., Jones H., Horiot J.C. et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881–10882. Radiother Oncol 2007;82(3):265–71.</mixed-citation><mixed-citation xml:lang="ru">Veronesi U., Luini A., Del Vecchio M. et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med 1993;328(22):1587–91. 14. Antonini N., Jones H., Horiot J.C. et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881–10882. Radiother Oncol 2007;82(3):265–71.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">15. Foote R.L., Johnson R.E., Donohue J.H. et al. Trends in surgical treatment of breast cancer at Mayo Clinic 1980–2004. Breast 2008;17(6):555–62.</mixed-citation><mixed-citation xml:lang="ru">Foote R.L., Johnson R.E., Donohue J.H. et al. Trends in surgical treatment of breast cancer at Mayo Clinic 1980–2004. Breast 2008;17(6):555–62.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">16. Morrow M., White J., Moughan J. et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. Am J Clin Oncol 2001;19(8):2254–62.</mixed-citation><mixed-citation xml:lang="ru">Morrow M., White J., Moughan J. et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. Am J Clin Oncol 2001;19(8):2254–62.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">17. National Comprehensive Cancer Network. Breast cancer. NCCN clinical practice guidelines in oncology: Version 3.2012. http:// www.nccn.org/professionals/physician_gls.</mixed-citation><mixed-citation xml:lang="ru">National Comprehensive Cancer Network. Breast cancer. NCCN clinical practice guidelines in oncology: Version 3.2012. http:// www.nccn.org/professionals/physician_gls.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">18. Pezner R.D., Wagman L.D., Ben-Ezra J., Odom-Maryon T. Breast conservation therapy: local tumor control in patients with pathologically clear margins who receive 5000 cGy breast irradiation without local boost. Breast Cancer Res Treat 1994;32(3):261–7.</mixed-citation><mixed-citation xml:lang="ru">Pezner R.D., Wagman L.D., Ben-Ezra J., Odom-Maryon T. Breast conservation therapy: local tumor control in patients with pathologically clear margins who receive 5000 cGy breast irradiation without local boost. Breast Cancer Res Treat 1994;32(3):261–7.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">19. Polednak A.P. Trends in, and predictors of, breast-conserving surgery and radiotherapy for breast cancer in Connecticut, 1988–1997. Int J Radiat Oncol Biol Phys 2002;53(1):157–6.</mixed-citation><mixed-citation xml:lang="ru">Polednak A.P. Trends in, and predictors of, breast-conserving surgery and radiotherapy for breast cancer in Connecticut, 1988–1997. Int J Radiat Oncol Biol Phys 2002;53(1):157–6.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">20. Shafiq J., Delaney G., Barton M.B. An evidence-based estimation of local control and survival benefit of radiotherapy for breast cancer. Radiother Oncol 2007;84(1):11–7.</mixed-citation><mixed-citation xml:lang="ru">Shafiq J., Delaney G., Barton M.B. An evidence-based estimation of local control and survival benefit of radiotherapy for breast cancer. Radiother Oncol 2007;84(1):11–7.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">21. Yarnold J., Ashton A., Bliss J. et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomized trial. Radiother Oncol 2005;75(1):9–17.</mixed-citation><mixed-citation xml:lang="ru">Yarnold J., Ashton A., Bliss J. et al. Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomized trial. Radiother Oncol 2005;75(1):9–17.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">22. Van Nes J.G.H., van de Velde C.J.H. The preferred treatment for young women with breast cancer – mastectomy versus breast conservation. Breast 2006;15(Suppl 2): 3–10.</mixed-citation><mixed-citation xml:lang="ru">Van Nes J.G.H., van de Velde C.J.H. The preferred treatment for young women with breast cancer – mastectomy versus breast conservation. Breast 2006;15(Suppl 2): 3–10.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">23. Silva O.T., Zurrida S. Breast сancer: а practical guide. 3th ed. NY: Elsevier, 2005. Рр. 171–83.</mixed-citation><mixed-citation xml:lang="ru">Silva O.T., Zurrida S. Breast сancer: а practical guide. 3th ed. NY: Elsevier, 2005. Рр. 171–83.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">24. Kunos C., Latson L., Overmoyer B. et al. Breast conservation surgery achieving &gt; or = 2 mm tumorfree margins results in decreased local regional recurrence rates. Breast J 2006;12(1):28–36.</mixed-citation><mixed-citation xml:lang="ru">Kunos C., Latson L., Overmoyer B. et al. Breast conservation surgery achieving &gt; or = 2 mm tumorfree margins results in decreased local regional recurrence rates. Breast J 2006;12(1):28–36.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">25. van Dongen J.A., Bartelink H., Fentiman I.S. et al. Randomized clinical trial to assess the value of breast conserving therapy in stage I and stage II breast cancer, EORTC 10801 trial. J Natl Cancer Inst Monogr 1992;(11):15–8.</mixed-citation><mixed-citation xml:lang="ru">van Dongen J.A., Bartelink H., Fentiman I.S. et al. Randomized clinical trial to assess the value of breast conserving therapy in stage I and stage II breast cancer, EORTC 10801 trial. J Natl Cancer Inst Monogr 1992;(11):15–8.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">26. Golhirsch A., Ingle J.N., Gelber R.D. et al. Thresholds for therapies: highlights</mixed-citation><mixed-citation xml:lang="ru">Golhirsch A., Ingle J.N., Gelber R.D. et al. Thresholds for therapies: highlights</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><mixed-citation>of the St Gallen International Expert Consensus on the рrimary therapy of early breast cancer. Ann Oncol 2009;20(8): 1319–29.</mixed-citation></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">27. Begg A., van der Kogel A. Clinical radiobiology in 2008. Radiother Oncol 2008;86(3):295–9.</mixed-citation><mixed-citation xml:lang="ru">Begg A., van der Kogel A. Clinical radiobiology in 2008. Radiother Oncol 2008;86(3):295–9.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">28. Budach W., Fourquet A., Poortmans P. Recent advances in breast cancer radiotherapy. Eur J Cancer Suppl 2008;6(7):13–4.</mixed-citation><mixed-citation xml:lang="ru">Budach W., Fourquet A., Poortmans P. Recent advances in breast cancer radiotherapy. Eur J Cancer Suppl 2008;6(7):13–4.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">29. NCCN GuidelinesTM Version 2.2011, Р. 38; NSABP Clinical Trials Overview, Protocol B-39/RTOG (in press). http://www.nsabp.pitt. edu.</mixed-citation><mixed-citation xml:lang="ru">NCCN GuidelinesTM Version 2.2011, Р. 38; NSABP Clinical Trials Overview, Protocol B-39/RTOG (in press). http://www.nsabp.pitt. edu.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">30. Pignol J., Olivotto I., Rakovitch E. et al. Plenary 1: Phase III randomized study of intensity modulated radiation therapy versus standard wedging technique for adjuvant breast radiotherapy. Int J Radiat Oncol Biol Phys 2006;66(3 Suppl):1.</mixed-citation><mixed-citation xml:lang="ru">Pignol J., Olivotto I., Rakovitch E. et al. Plenary 1: Phase III randomized study of intensity modulated radiation therapy versus standard wedging technique for adjuvant breast radiotherapy. Int J Radiat Oncol Biol Phys 2006;66(3 Suppl):1.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">31. Fourquet A., Campana F., Rosenwald J. et al. Breast irradiation in the lateral decubitus position technique of the Institute Curie. Radiother Oncol 1991;22(4):261–5.</mixed-citation><mixed-citation xml:lang="ru">Fourquet A., Campana F., Rosenwald J. et al. Breast irradiation in the lateral decubitus position technique of the Institute Curie. Radiother Oncol 1991;22(4):261–5.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">32. Donovan E. Randomized trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 2007;82(3):254–64.</mixed-citation><mixed-citation xml:lang="ru">Donovan E. Randomized trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 2007;82(3):254–64.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">33. Mathew J., Barthelmes L., Neminathan S. et al. Comparative study of lymphoedema with axillary node dissection versusaxillary node sampling with radiotherapy in patients undergoing breast conservation surgery. Eur J Surg Oncol 2006;32(7):729–32.</mixed-citation><mixed-citation xml:lang="ru">Mathew J., Barthelmes L., Neminathan S. et al. Comparative study of lymphoedema with axillary node dissection versusaxillary node sampling with radiotherapy in patients undergoing breast conservation surgery. Eur J Surg Oncol 2006;32(7):729–32.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">34. Pignol J.P., Olivotto I., Rakovitch E. et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008;26(13):2085–92.</mixed-citation><mixed-citation xml:lang="ru">Pignol J.P., Olivotto I., Rakovitch E. et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008;26(13):2085–92.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">35. Bartelink H., Horiot J.C., Poortmans P. et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001;345(19):1378–87.</mixed-citation><mixed-citation xml:lang="ru">Bartelink H., Horiot J.C., Poortmans P. et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001;345(19):1378–87.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">36. Brady L.W., Heilmann H.P., Molls M., Nieder C. Radiation оncology: аn еvidence- based approach. Medical radiology. 2008. Р. 11–127.</mixed-citation><mixed-citation xml:lang="ru">Brady L.W., Heilmann H.P., Molls M., Nieder C. Radiation оncology: аn еvidence- based approach. Medical radiology. 2008. Р. 11–127.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">37. Clarke M., Collins R., Darby S. et al. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. An overview of the randomized trials. Lancet 2005;366(9503):2087–106.</mixed-citation><mixed-citation xml:lang="ru">Clarke M., Collins R., Darby S. et al. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. An overview of the randomized trials. Lancet 2005;366(9503):2087–106.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">38. Favorable and unfavorable effects on long- term survival of radiotherapy for early breast cancer: an overview of the randomized trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet 2000;355(9217):1757–70.</mixed-citation><mixed-citation xml:lang="ru">Favorable and unfavorable effects on long- term survival of radiotherapy for early breast cancer: an overview of the randomized trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet 2000;355(9217):1757–70.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">39. Hepel J.T., Tokita M., MacAusland S.G. et al. Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2009;75(5):1290–6.</mixed-citation><mixed-citation xml:lang="ru">Hepel J.T., Tokita M., MacAusland S.G. et al. Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2009;75(5):1290–6.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">40. Van Dongen J.A., Bartelink H., Fentiman I.S. et al. Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10001, breast conservation compared with mastectomy in TNM stage I and II breast cancer. Eur J Cancer 1992;28:801–5.</mixed-citation><mixed-citation xml:lang="ru">Van Dongen J.A., Bartelink H., Fentiman I.S. et al. Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10001, breast conservation compared with mastectomy in TNM stage I and II breast cancer. Eur J Cancer 1992;28:801–5.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">41. Whelan T.J., Julian J., Wright J. et al. Does loko-regional radiational therapy improve survival in breast cancer? A meta- analysis. J Clin Oncol 2000;18(6):1220–9.</mixed-citation><mixed-citation xml:lang="ru">Whelan T.J., Julian J., Wright J. et al. Does loko-regional radiational therapy improve survival in breast cancer? A meta- analysis. J Clin Oncol 2000;18(6):1220–9.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">42. Freedman, G.M., Anderson P.R., Goldstein L.J. et al. Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost. Int J Radiat Oncol Biol Phys 2007;68(2):347–53. 43. Golhirsch A., Glick J.H., Gelber R.D.</mixed-citation><mixed-citation xml:lang="ru">Freedman, G.M., Anderson P.R., Goldstein L.J. et al. Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost. Int J Radiat Oncol Biol Phys 2007;68(2):347–53. 43. Golhirsch A., Glick J.H., Gelber R.D.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><mixed-citation>et al. Meeting highlights: international expert consensus on the primary therapy of early breast cancer. ESO – Moscow breast cancer forum. 2005. Pp. 3–17.</mixed-citation></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">44. Louis-Sylvestre C., Clough K.B., Falcou M.C. et al. Radiotherapy for early breast cancer: 15 year results. 2001. Pp. 10–3. 45. Veronesi U., Luini A., Galimberti V. Zurrida S. Conservation approaches for the management of stage I/II carcinoma of the breast. Milan Cancer Institute trials World. J Surg 1994;18(1):70–5.</mixed-citation><mixed-citation xml:lang="ru">Louis-Sylvestre C., Clough K.B., Falcou M.C. et al. Radiotherapy for early breast cancer: 15 year results. 2001. Pp. 10–3. 45. Veronesi U., Luini A., Galimberti V. Zurrida S. Conservation approaches for the management of stage I/II carcinoma of the breast. Milan Cancer Institute trials World. J Surg 1994;18(1):70–5.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">46. Boecker W., Löchnert C., Korsching E. Differential expression of ER and Ki67 in normal breast tissue and proliferating breast disease: further support of the progenitor cell concept? Eur J Cancer 2007;3(5):4–5.</mixed-citation><mixed-citation xml:lang="ru">Boecker W., Löchnert C., Korsching E. Differential expression of ER and Ki67 in normal breast tissue and proliferating breast disease: further support of the progenitor cell concept? Eur J Cancer 2007;3(5):4–5.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">47. Mannino M., Yarnold J.R. Local relapse rates are falling after breast conserving surgery and systemic therapy for early breast cancer: сan radiotherapy ever be safely withheld? Radiother Oncol 2009;90(1):14–22.</mixed-citation><mixed-citation xml:lang="ru">Mannino M., Yarnold J.R. Local relapse rates are falling after breast conserving surgery and systemic therapy for early breast cancer: сan radiotherapy ever be safely withheld? Radiother Oncol 2009;90(1):14–22.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">48. Truong P.T., Bernstein V., Lesperace M. et al. Radiotherapy omission after breast- conserving surgery is associated with reduced breast cancer-specific survival in elderly women with breast cancer. Am J Surg 2006;191(6):749–55.</mixed-citation><mixed-citation xml:lang="ru">Truong P.T., Bernstein V., Lesperace M. et al. Radiotherapy omission after breast- conserving surgery is associated with reduced breast cancer-specific survival in elderly women with breast cancer. Am J Surg 2006;191(6):749–55.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">49. Winzer K.J., Sauer R., Sauerbrei W. et al.; German Breast Cancer Study Group. Radiation therapy after breast-conserving surgery: randomized trial in patients with low risk of recurrence. Eur J Cancer 2004;40(7):998–1005.</mixed-citation><mixed-citation xml:lang="ru">Winzer K.J., Sauer R., Sauerbrei W. et al.; German Breast Cancer Study Group. Radiation therapy after breast-conserving surgery: randomized trial in patients with low risk of recurrence. Eur J Cancer 2004;40(7):998–1005.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">50. Voordeckers G., Van de Steene J., Vinh-Hung V., Storme G. et al. Adjuvant radiotherapy after mastectomy for pT1-pT2 node negative (pN0) breast cancer: is it worth the effort? Radiother Oncol 2003;68(3): 227–31.</mixed-citation><mixed-citation xml:lang="ru">Voordeckers G., Van de Steene J., Vinh-Hung V., Storme G. et al. Adjuvant radiotherapy after mastectomy for pT1-pT2 node negative (pN0) breast cancer: is it worth the effort? Radiother Oncol 2003;68(3): 227–31.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">51. Borgen P.I., Sacchini V., Zurrida S. et al. Local control matters breast diseases. A Year Book Quarterly 2006;17(3):210–2.</mixed-citation><mixed-citation xml:lang="ru">Borgen P.I., Sacchini V., Zurrida S. et al. Local control matters breast diseases. A Year Book Quarterly 2006;17(3):210–2.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">52. Breast surgical techniques and interdisciplinary management. F.M. Dirbas, E.H. Carol, еds. Springer Science + Business Media, 2011. Рр. 813–28.</mixed-citation><mixed-citation xml:lang="ru">Breast surgical techniques and interdisciplinary management. F.M. Dirbas, E.H. Carol, еds. Springer Science + Business Media, 2011. Рр. 813–28.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">53. Fyles A.W., McCready D.R., Manchul L.A. et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 2004;351(10):963–70.</mixed-citation><mixed-citation xml:lang="ru">Fyles A.W., McCready D.R., Manchul L.A. et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 2004;351(10):963–70.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">54. Hughes K.S., Schnaper L.A., Berry D. et al. Lumpectomy plus tamoxifen with</mixed-citation><mixed-citation xml:lang="ru">Hughes K.S., Schnaper L.A., Berry D. et al. Lumpectomy plus tamoxifen with</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><mixed-citation>or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004;351(10):971–7.</mixed-citation></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">55. Bartelink H. Impact of a higher radiation dose on local control and survival in breast- conserving therapy of early breast cancer: 10-year results of the Randomized Boost Versus No Boost EORTC 22881–10882 Trial. J Clin Oncol 2007;25(22):3259–65.</mixed-citation><mixed-citation xml:lang="ru">Bartelink H. Impact of a higher radiation dose on local control and survival in breast- conserving therapy of early breast cancer: 10-year results of the Randomized Boost Versus No Boost EORTC 22881–10882 Trial. J Clin Oncol 2007;25(22):3259–65.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">56. Jones H., Antonini N., Colette L. et al. The impact of boost dose and margins on the local recurrence rate in breast conserving therapy: results from the EORTC boost-no boost trial. Int J Radiat Oncol Biol Phys 2007;69(Suppl 1):S2–3.</mixed-citation><mixed-citation xml:lang="ru">Jones H., Antonini N., Colette L. et al. The impact of boost dose and margins on the local recurrence rate in breast conserving therapy: results from the EORTC boost-no boost trial. Int J Radiat Oncol Biol Phys 2007;69(Suppl 1):S2–3.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">57. Bantema-Joppe E.J., van der Laan H.P., Maduro J.H. et al. Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. Radiat Oncol 2011;100:215–20.</mixed-citation><mixed-citation xml:lang="ru">Bantema-Joppe E.J., van der Laan H.P., Maduro J.H. et al. Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. Radiat Oncol 2011;100:215–20.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">58. Bantema-Joppe E.J., Schilstra C., de Bock G.H. et al. Tree-dimentional conformal simultaneously integrated boost technique for breast-conserving therapy: results on local control and survival. Int J Radiat Oncol Biol Phys 2012;83:471–7.</mixed-citation><mixed-citation xml:lang="ru">Bantema-Joppe E.J., Schilstra C., de Bock G.H. et al. Tree-dimentional conformal simultaneously integrated boost technique for breast-conserving therapy: results on local control and survival. Int J Radiat Oncol Biol Phys 2012;83:471–7.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">59. Hurkmans C.W., Meijer C.J., van Vliet-Vroegindeweij C. et al. High-dose simultaneosly intergated breast boost using intensity-modulated radiotherapy and inverse optimization. Int J Radiation Oncol Biol Phys 2006;66(3):923–30.</mixed-citation><mixed-citation xml:lang="ru">Hurkmans C.W., Meijer C.J., van Vliet-Vroegindeweij C. et al. High-dose simultaneosly intergated breast boost using intensity-modulated radiotherapy and inverse optimization. Int J Radiation Oncol Biol Phys 2006;66(3):923–30.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">60. Singla R., King S., Albuquerque K. et al. Simultaneous-integrated boost intensity- modulated radiation therapy (SIB-IMRT) in the treatment of early-stage left-sided breast carcinoma. Med Dosim 2006;31(3):190–6.</mixed-citation><mixed-citation xml:lang="ru">Singla R., King S., Albuquerque K. et al. Simultaneous-integrated boost intensity- modulated radiation therapy (SIB-IMRT) in the treatment of early-stage left-sided breast carcinoma. Med Dosim 2006;31(3):190–6.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">61. van der Laan H.P., Dolsma W.V., Maduro J.H. et al. Three-dimensional conformal simultaneously integrated boost technique</mixed-citation><mixed-citation xml:lang="ru">van der Laan H.P., Dolsma W.V., Maduro J.H. et al. Three-dimensional conformal simultaneously integrated boost technique</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><mixed-citation>for breast-conserving radiotherapy. Int J Radiat Oncol Biol Phys 2007;68(4):1018–23.</mixed-citation></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">62. Guerrero M., Li X.A., Earl M.A. et al. Simultaneous integrated boost for breast cancer using IMRT: a radiobiological and treatment planning study. Int J Radiat Oncol Biol Phys 2004;59(5):1513–22.</mixed-citation><mixed-citation xml:lang="ru">Guerrero M., Li X.A., Earl M.A. et al. Simultaneous integrated boost for breast cancer using IMRT: a radiobiological and treatment planning study. Int J Radiat Oncol Biol Phys 2004;59(5):1513–22.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">63. Freedman G.M., White J.R., Artur D.W., Li X.A. et al. Accelerated fractionation with</mixed-citation><mixed-citation xml:lang="ru">Freedman G.M., White J.R., Artur D.W., Li X.A. et al. Accelerated fractionation with</mixed-citation></citation-alternatives></ref><ref id="B68"><label>68.</label><mixed-citation>a concurrent boost for early stage breast cancer. Radiat Oncol 2013;106: 15–20.</mixed-citation></ref><ref id="B69"><label>69.</label><citation-alternatives><mixed-citation xml:lang="en">64. McDonald M.W., Godette K.D., Whitaker D.J. et al. Three-year outcomes</mixed-citation><mixed-citation xml:lang="ru">McDonald M.W., Godette K.D., Whitaker D.J. et al. Three-year outcomes</mixed-citation></citation-alternatives></ref><ref id="B70"><label>70.</label><mixed-citation>of breast intensity-modulated radiation therapy with simultaneous integrated boost. Int</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>J Radiat Oncol Biol Phys 2010;77(2):523–30. 65. James M.L., Lehman M., Hider P.N. et al. An evidence-based estimation of local control and survival benefit of radiotherapy for breast cancer. Radiother Oncol 2007;84(1):11–7.</mixed-citation></ref><ref id="B72"><label>72.</label><citation-alternatives><mixed-citation xml:lang="en">66. Truong P.T., Jones S.O., Kader H.A. et al. Patients with T1 to T2 breast cancer with one to three positive nodes have higher local and regional recurrence risks compared with node- negative patients after breast-conserving surgery and whole-breast radiotherapy international. J Radiat Oncol Biol Phys 2009;73:357–64.</mixed-citation><mixed-citation xml:lang="ru">Truong P.T., Jones S.O., Kader H.A. et al. Patients with T1 to T2 breast cancer with one to three positive nodes have higher local and regional recurrence risks compared with node- negative patients after breast-conserving surgery and whole-breast radiotherapy international. J Radiat Oncol Biol Phys 2009;73:357–64.</mixed-citation></citation-alternatives></ref><ref id="B73"><label>73.</label><citation-alternatives><mixed-citation xml:lang="en">67. Ahn P.H., Vu H.T., Lannin D. et al. Sequence of radiotherapy with tamoxifen</mixed-citation><mixed-citation xml:lang="ru">Ahn P.H., Vu H.T., Lannin D. et al. Sequence of radiotherapy with tamoxifen</mixed-citation></citation-alternatives></ref><ref id="B74"><label>74.</label><mixed-citation>in conservatively managed breast cancer does not affect local relapse rates. J Clin Oncol 2005;23(1):17–23.</mixed-citation></ref><ref id="B75"><label>75.</label><citation-alternatives><mixed-citation xml:lang="en">68. Harris E.E., Christensen V.J., Hwang W.T. et al. Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment. J Clin Oncol 2005;23(1):11–23.</mixed-citation><mixed-citation xml:lang="ru">Harris E.E., Christensen V.J., Hwang W.T. et al. Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment. J Clin Oncol 2005;23(1):11–23.</mixed-citation></citation-alternatives></ref><ref id="B76"><label>76.</label><citation-alternatives><mixed-citation xml:lang="en">69. Pierce L.J., Hutchins L.F., Green S.R. et al. Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer. J Clin Oncol 2005;23(1):24–9.</mixed-citation><mixed-citation xml:lang="ru">Pierce L.J., Hutchins L.F., Green S.R. et al. Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer. J Clin Oncol 2005;23(1):24–9.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
