Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press23610.17650/1994-4098-2010-0-2-84-88GYNECOLOGY. TREATMENTГИНЕКОЛОГИЯ. ЛЕЧЕНИЕEpithelioid trophoblastic tumor: Clinical presentation, diagnosis, and treatmentОсобенности клиники, диагностики и лечения эпителиоидной трофобластической опухолиLisayevD. A.ЛисаевД. А.
Russian Federation
lisaev84@mail.ruToloknovB. O.ТолокновБ. О.
Russian Federation
MakhovaE. E.МаховаЕ. Е.
Russian Federation
MarkinaI. V.МаркинаИ. В.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Department of Oncology, Moscow State University of Medicine and DentistryГУ РОНЦ им. Н.Н. Блохина РАМНкафедра онкологии ФПДО МГМСУN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Department of Oncology, Moscow State University of Medicine and DentistryГУ РОНЦ им. Н.Н. Блохина РАМНкафедра онкологии ФПДО МГМСУ270520102848827082014270820142010https://ojrs.abvpress.ru/ojrs/article/view/236

Epithelioid trophoblastic tumor (ETT) is a rare form of trophoblastic disease, which is characterized by high malignancy and a number of diagnostic features: a long interval between the last pregnancy and labor and the onset of the disease; a visual pattern at gynecological examination, relatively low β-chorionic gonadotropin (CG) levels, as well as the diffuse expression of cytokeratins-7 (+++) and -18 (+++), р63 (nuclear ++), E-cadherin (+++), EGFR (+), and CD-117(++) by tumor cells, as determined by immunohistochemical assay, and focal expression of CG (++) and PLAP (+) by these cells.

Эпителиоидная трофобластическая опухоль — чрезвычайно редкая форма трофобластической болезни, которая характеризуется высокой злокачественностью и рядом диагностических особенностей: длительный период времени от последней беременности и родов до начала заболевания, визуальная картина при гинекологическом обследовании, относительно низкий уровень β-хорионического гонадотропина и определение при иммуногистохимическом исследовании диффузной экспрессии клетками опухоли цитокератинов-7 (+++) и -18 (+++), р63 (ядерная ++), E-cadherin (+++), EGFR (+), CD-117(++), фокальной экспрессии этими клетками ХГ (++) и PLAP (+).

epithelioid trophoblastic tumorsquamous cell carcinoma of the cervix uteriintermediate trophoblastэпителиоидная трофобластическая опухольплоскоклеточный рак шейки маткипромежуточный трофобласт1. Fadare O., Parkash V., Carcangiu M.L., Hui P. Epithelioid trophoblastic tumor: сlinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol 2006;19:75–82.Fadare O., Parkash V., Carcangiu M.L., Hui P. Epithelioid trophoblastic tumor: сlinicopathological features with an emphasis on uterine cervical involvement. Mod Pathol 2006;19:75–82.2. Mazur M., Kurman R.J. Diagnosis of endometrial biopsies and curettings: a practical approach. 2nd ed. NY: Springer, 2004.Mazur M., Kurman R.J. Diagnosis of endometrial biopsies and curettings: a practical approach. 2nd ed. NY: Springer, 2004.3. Shih I.M., Kurman R.J. Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol 1998;22:1393–403.Shih I.M., Kurman R.J. Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol 1998;22:1393–403.4. Lo C., Low I., Tan A.L., Baranyai J. Epithelioid trophoblastic tumor: a case report. Int J Gynecol Can 2006;16:1473–6.Lo C., Low I., Tan A.L., Baranyai J. Epithelioid trophoblastic tumor: a case report. Int J Gynecol Can 2006;16:1473–6.5. Kuo K.T., Chen M.J., Lin M.C. Epithelioid trophoblastic tumor of the broad ligament: a case report and review of the literature. Am J Surg Pathol 2004;28:405–9.Kuo K.T., Chen M.J., Lin M.C. Epithelioid trophoblastic tumor of the broad ligament: a case report and review of the literature. Am J Surg Pathol 2004;28:405–9.6. Hamazaki S., Nakamato S., Okino T. et al. Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions. Hum Pathol 1999;30:1321–7.Hamazaki S., Nakamato S., Okino T. et al. Epithelioid trophoblastic tumor: morphological and immunohistochemical study of three lung lesions. Hum Pathol 1999;30:1321–7.7. Allison K.H., Love J.E., Garcia R.L. Epithelioid trophoblastic tumor. Review of a rare neoplasm of the chorionic-type intermediate trophoblast. Arch Pathol Lab Med 2006;130:1875–7.Allison K.H., Love J.E., Garcia R.L. Epithelioid trophoblastic tumor. Review of a rare neoplasm of the chorionic-type intermediate trophoblast. Arch Pathol Lab Med 2006;130:1875–7.8. Meydanli M.M., Kucukali T., Usubutun A. et al. Epithelioid trophoblastic tumor of the endocervix: a case report. Gynecol Oncol 2002;87:219–24.Meydanli M.M., Kucukali T., Usubutun A. et al. Epithelioid trophoblastic tumor of the endocervix: a case report. Gynecol Oncol 2002;87:219–24.9. Oldt R.J., Kurman R.J., Shih I.M. Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin. Am J Pathol 2002;161:1033–7.Oldt R.J., Kurman R.J., Shih I.M. Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin. Am J Pathol 2002;161:1033–7.10. Narita F., Takeuchi K., Hamana S. et al. Epithelioid trophoblastic tumor (ETT) initially interpreted as cervical cancer. Int J Gynecol Can 2003;13:551–4.Narita F., Takeuchi K., Hamana S. et al. Epithelioid trophoblastic tumor (ETT) initially interpreted as cervical cancer. Int J Gynecol Can 2003;13:551–4.11. Mao T., Seidman J.D., Kurman R.J., Shih I. Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor – an aid in differential diagnosis. Am J Surg Pathol 2006;30:1105–10.Mao T., Seidman J.D., Kurman R.J., Shih I. Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor – an aid in differential diagnosis. Am J Surg Pathol 2006;30:1105–10.12. Knox S., Brooks S.E., Wong-You- Cheong J. et al. Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with a hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report. Gynecol Oncol 2002;85:204–8.Knox S., Brooks S.E., Wong-You- Cheong J. et al. Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with a hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report. Gynecol Oncol 2002;85:204–8.