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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">241</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2010-0-3-5-10</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. TOPICAL ISSUE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Prognostic factors in T3–Т4N0M0 breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Прогностические факторы при раке молочной железы T3–Т4N0M0 стадий</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vysotskaya</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Высоцкая</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>vysotskaya.irina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Letyagin</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Летягин</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maksimov</surname><given-names>K. V.</given-names></name><name xml:lang="ru"><surname>Максимов</surname><given-names>К. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Cancer Dispensary Four, South Administrative District, Moscow</institution></aff><aff><institution xml:lang="ru">Онкологический диспансер No4 ЮАО г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-08-28" publication-format="electronic"><day>28</day><month>08</month><year>2010</year></pub-date><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>5</fpage><lpage>10</lpage><history><date date-type="received" iso-8601-date="2014-08-28"><day>28</day><month>08</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-08-28"><day>28</day><month>08</month><year>2014</year></date></history><permissions><copyright-year>2010</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/241">https://ojrs.abvpress.ru/ojrs/article/view/241</self-uri><abstract xml:lang="en"><p>The study used the records of clinical observations of 145 patients with locally advanced T3–Т4N0M0 breast cancer (BC) who were treated at the N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, in 1998 to 2003. Based on the examined combination of prognostic factors, the authors identified the criteria that had the greatest impact on the prognosis of primary T3–Т4N0M0 BC, which must the standard for its determination in this category of patients.</p></abstract><trans-abstract xml:lang="ru"><p>В работе использованы материалы клинических наблюдений 145 пациенток с местно-распространенным раком молочной железы (РМЖ) T3–Т4N0M0 стадий, получавших лечение в ГУ РОНЦ им. Н.Н. Блохина РАМН в период с 1998 по 2003 г. На основании изученного комплекса прогностических факторов выделены критерии, оказывающие наибольшее влияние на прогноз при T3–Т4N0M0 стадиях первичного РМЖ, которые должны стать стандартом определения у данной категории больных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>locally advanced cancer</kwd><kwd>clinical and morphological prognostic factors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>местно-распространенный рак</kwd><kwd>клинические и морфологические факторы прогноза</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Аксель Е.М., Давыдов М.И. Статистика злокачественных новообразований в России и странах СНГ. М., 2005.</mixed-citation><mixed-citation xml:lang="ru">Аксель Е.М., Давыдов М.И. Статистика злокачественных новообразований в России и странах СНГ. 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