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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">288</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2009-0-1-2-41-43</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>PHARMACOTHERAPY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ФАРМАКОТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">ZOMETA IN COMPLEX TREATMENT FOR GENERALIZED BREAST CANCER: A CLINICAL CASE</article-title><trans-title-group xml:lang="ru"><trans-title>ЗОМЕТА В КОМПЛЕКСНОМ ЛЕЧЕНИИ ГЕНЕРАЛИЗОВАННОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bolotina</surname><given-names>L. V.</given-names></name><name xml:lang="ru"><surname>Болотина</surname><given-names>Л. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ibolotina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">P.A. Herzen Moscow Research Institute of Oncology</institution></aff><aff><institution xml:lang="ru">МНИОИ им. П.А. Герцена</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2009-05-01" publication-format="electronic"><day>01</day><month>05</month><year>2009</year></pub-date><issue>1-2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>41</fpage><lpage>43</lpage><history><date date-type="received" iso-8601-date="2014-09-01"><day>01</day><month>09</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-09-01"><day>01</day><month>09</month><year>2014</year></date></history><permissions><copyright-year>2009</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/288">https://ojrs.abvpress.ru/ojrs/article/view/288</self-uri><abstract xml:lang="en"><p>The paper describes a case of generalized breast cancer treated with Zometa in combination with chemotherapy. It shows it necessary to supplement chemotherapy with zoledronate in case of bone changes in order to improve the results the antitumor treatment performed.</p></abstract><trans-abstract xml:lang="ru"><p>Приведено клиническое наблюдение больной генерализованным раком молочной железы, для лечения которой был применен препарат Зо- мета в сочетании с химиотерапией. Продемонстрирована необходимость добавления золедроната к химиотерапии при наличии костных изменений для улучшения результатов проводимого противоопухолевого лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>bone involvement</kwd><kwd>Zometa</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>поражение костей</kwd><kwd>Зомета</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Coleman R.E. Skeletal complications of malignancy. 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