Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press30510.17650/1994-4098-2009-0-3-4-5-10MAMMOLOGY. TOPICAL ISSUEМАММОЛОГИЯ. АКТУАЛЬНАЯ ТЕМАLONG-TERM PROGNOSIS IN PATIENTS WITH A LOCAL BREAST CANCER RELAPSE AFTER ORGAN-SAVING TREATMENTОТДАЛЕННЫЙ ПРОГНОЗ У ПАЦИЕНТОК С МЕСТНЫМ РЕЦИДИВОМ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ ПОСЛЕ ОРГАНОСОХРАНЯЮЩЕГО ЛЕЧЕНИЯUimanovV. A.УймановВ. А.
Russian Federation
v.uimanov@mail.ruNechushkinM. I.НечушкинМ. И.
Russian Federation
GladilinaI. A.ГладилинаИ. А.
Russian Federation
TrigolosovA. V.ТриголосовА. В.
Russian Federation
MolodikovaN. R.МолодиковаН. Р.
Russian Federation
ChernykhM. V.ЧерныхМ. В.
Russian Federation
Radiology Department, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowОтделение радиохирургии ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва101120093-451010092014100920142009https://ojrs.abvpress.ru/ojrs/article/view/305

The paper presents the results of a follow-up of 861 patients who have undergone organ-saving treatment (OST) for early breast can- cer. The relapse rate was 7.3% (63/861). The main task was to study an association of survival rates with the predictors characteriz- ing a local relapse. Five-year overall survival after the start of treatment for a local relapse was 65.7% (standard error 8.3). A Cox multivariance regression analysis led to the conclusion that the local relapse is a statistically significant factor of worsening survival without distant metastases when it develops within 3 years after primary OST.

Представлены результаты наблюдения за 861 пациенткой, которой проведено органосохраняющее лечение (ОСЛ) по поводу ранних ста- дий рака молочной железы. Частота рецидивирования составила 7,3% (63 больные из 861). Основной задачей являлось изучение зависимо- сти выживаемости от прогностических факторов, характеризующих местный рецидив. Уровень общей 5-летней выживаемости от мо- мента лечения местного рецидива составил 65,7% (стандартная ошибка 8,3). На основе мультифакторного регрессионного анализа по модели Кокса был сделан вывод о том, что местный рецидив является статистически значимым фактором ухудшения выживаемости без отдаленных метастазов в том случае, если он развивается в сроки до 3 лет после первичного ОСЛ.

breast cancerlocal relapselong-term prognosisрак молочной железыместный рецидивотдаленный прогноз1. Моисеенко В.М. «Естественная история» роста рака молочной железы. Практ Онкол 2002;3(1): 6—14.Моисеенко В.М. «Естественная история» роста рака молочной железы. Практ Онкол 2002;3(1): 6—14.2. Fisher В., Fisher E. Biologic aspects of cancer-cell spread. Proceedings of the Fifth National Cancer Conference. Philadelphia, Pennsylvania: Lippincott, 1965. p. 105—22.Fisher В., Fisher E. Biologic aspects of cancer-cell spread. Proceedings of the Fifth National Cancer Conference. Philadelphia, Pennsylvania: Lippincott, 1965. p. 105—22.3. Van Dongen J.A., Voogd A.C., Fentiman I.S. et al. Long-term results of a randomized trial comparing breast- conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000;92:1143—50.Van Dongen J.A., Voogd A.C., Fentiman I.S. et al. Long-term results of a randomized trial comparing breast- conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000;92:1143—50.4. Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a ran- domized study comparing breast-con- serving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347:1217—32.Veronesi U., Cascinelli N., Mariani L. et al. Twenty-year follow-up of a ran- domized study comparing breast-con- serving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347:1217—32.5. Krauss D.J., Kestin L.L., Mitchell C. et al. Changes in temporal patterns of local failure after breast-conserving ther- apy and their prognostic implications. Int J Radiat Oncol Biol Phys 2004;60: 731—40.Krauss D.J., Kestin L.L., Mitchell C. et al. Changes in temporal patterns of local failure after breast-conserving ther- apy and their prognostic implications. Int J Radiat Oncol Biol Phys 2004;60: 731—40.6. Calle R., Vilcoq J.R., Zafrani B. et al. Local control and survival of breast can- cer treated by limited surgery followed by irradiation. Int J Radiat Oncol Biol Phys 1986;(12):873—8.Calle R., Vilcoq J.R., Zafrani B. et al. Local control and survival of breast can- cer treated by limited surgery followed by irradiation. Int J Radiat Oncol Biol Phys 1986;(12):873—8.7. Kurtz J.M., Amalric R., Brandone H. et al. Local recurrence after breast-con- serving surgery and radiotherapy. Frequency, time course, and prognosis. Cancer 1989;63(10):1912—7.Kurtz J.M., Amalric R., Brandone H. et al. Local recurrence after breast-con- serving surgery and radiotherapy. Frequency, time course, and prognosis. Cancer 1989;63(10):1912—7.8. Van Tienhoven G., Voogd A.C., Peterse J.L. et al. Prognosis after treat- ment for loco-regional recurrence after mastectomy or breast-conserving therapy in two randomised trials (EORTC 10801 and DBCG-82TM). EORTC Breast Cancer Cooperative Group and the Danish Breast Cancer Cooperative Group. Eur J Cancer 1999;35(1): 32—8.Van Tienhoven G., Voogd A.C., Peterse J.L. et al. Prognosis after treat- ment for loco-regional recurrence after mastectomy or breast-conserving therapy in two randomised trials (EORTC 10801 and DBCG-82TM). EORTC Breast Cancer Cooperative Group and the Danish Breast Cancer Cooperative Group. Eur J Cancer 1999;35(1): 32—8.9. Fisher B., Anderson S., Fisher E.R. et al. Significance of ipsilateral breast tumour recurrence after lumpectomy. Lancet 1991;338(8763):327—31.Fisher B., Anderson S., Fisher E.R. et al. Significance of ipsilateral breast tumour recurrence after lumpectomy. Lancet 1991;338(8763):327—31.10. Rouzier R., Extra J.-M., Carton M. et al. Primary chemotherapy for operable breast cancer: Incidence and prognostic significance of ipsilateral breast tumor recurrence after breast-conserving sur- gery. J Clin Oncol 2001;19(18):3828—35.Rouzier R., Extra J.-M., Carton M. et al. Primary chemotherapy for operable breast cancer: Incidence and prognostic significance of ipsilateral breast tumor recurrence after breast-conserving sur- gery. J Clin Oncol 2001;19(18):3828—35.11. Voogd A.C., van Oost F.J., Rutgers E.J. et al. Long-term prognosis of patients with local recurrence after conservative surgery and radiotherapy for early breast cancer. Eur J Cancer 2005:41(17):2637—2544.Voogd A.C., van Oost F.J., Rutgers E.J. et al. Long-term prognosis of patients with local recurrence after conservative surgery and radiotherapy for early breast cancer. Eur J Cancer 2005:41(17):2637—2544.12. Fredriksson I., Liljegren G., Arnesson L.G. et al. Local recurrence in the breast after conservative surgery — a study of prognosis and prognostic fac- tors in 391 women. Eur J Cancer 2002;(38):1860.Fredriksson I., Liljegren G., Arnesson L.G. et al. Local recurrence in the breast after conservative surgery — a study of prognosis and prognostic fac- tors in 391 women. Eur J Cancer 2002;(38):1860.13. Le^ M.G., Arriagada R., Spielmann M. et al. Prognostic factors for death after an isolated local recur- rence in patients with early-stage breast carcinoma. Cancer 2002;94(11): 2813—20.Le^ M.G., Arriagada R., Spielmann M. et al. Prognostic factors for death after an isolated local recur- rence in patients with early-stage breast carcinoma. Cancer 2002;94(11): 2813—20.14. Huang E., Buchholz T.A., Meric F. et al. Classifying local disease recurrences after breast conservation therapy based on location and histology: new primary tumors have more favorable outcomes than true local disease recurrences. Cancer 2002;95(10):2059—67.Huang E., Buchholz T.A., Meric F. et al. Classifying local disease recurrences after breast conservation therapy based on location and histology: new primary tumors have more favorable outcomes than true local disease recurrences. Cancer 2002;95(10):2059—67.15. Smith T.E., Lee D., Turner B. et al. True recurrence vs. new primary ipsilater- al breast tumor relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management. Int J Radiat Oncol Biol Phys 2000;48:1281—9.Smith T.E., Lee D., Turner B. et al. True recurrence vs. new primary ipsilater- al breast tumor relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management. Int J Radiat Oncol Biol Phys 2000;48:1281—9.16. Fortin A., Larochelle M., Laverdiere J. et al. Local failure is responsible for the decrease in survival for patients with breast cancer treated with conservative surgery and postoperative radiotherapy. J Clin Oncol 1999;17(1):101—9.Fortin A., Larochelle M., Laverdiere J. et al. Local failure is responsible for the decrease in survival for patients with breast cancer treated with conservative surgery and postoperative radiotherapy. J Clin Oncol 1999;17(1):101—9.17. Gage I., Schnitt S.J., Recht A. et al. Skin recurrences after breast-conserving therapy for early-stage breast cancer. J Clin Oncol 1998;16(2):480—6.Gage I., Schnitt S.J., Recht A. et al. Skin recurrences after breast-conserving therapy for early-stage breast cancer. J Clin Oncol 1998;16(2):480—6.18. Нечушкин М.И. Лечение больных раком молочной железы центральной и медиальной локализации с использованием радиохирургических методик. Дис. ... докт. мед. наук. М., 2001.Нечушкин М.И. Лечение больных раком молочной железы центральной и медиальной локализации с использованием радиохирургических методик. Дис. ... докт. мед. наук. М., 2001.