<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">310</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2009-0-3-4-276-287</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ЛЕЧЕНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">GENERAL PRINCIPLES OF DRUG TREATMENT FOR PRIMARY OPERABLE AND LOCALLY ADVANCED BREAST CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>ОБЩИЕ ПРИНЦИПЫ ЛЕКАРСТВЕННОГО ЛЕЧЕНИЯ ПЕРВИЧНО-ОПЕРАБЕЛЬНОГО И МЕСТНО-РАСПРОСТРАНЕННОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Artamonova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Артамонова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2009-11-10" publication-format="electronic"><day>10</day><month>11</month><year>2009</year></pub-date><issue>3-4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>29</fpage><lpage>33</lpage><history><date date-type="received" iso-8601-date="2014-09-10"><day>10</day><month>09</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-09-10"><day>10</day><month>09</month><year>2014</year></date></history><permissions><copyright-year>2009</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/310">https://ojrs.abvpress.ru/ojrs/article/view/310</self-uri><abstract xml:lang="en"><p>GENERAL PRINCIPLES OF DRUG TREATMENT FOR PRIMARY OPERABLE AND LOCALLY ADVANCED BREAST CANCER</p></abstract><trans-abstract xml:lang="ru"><p>ОБЩИЕ ПРИНЦИПЫ ЛЕКАРСТВЕННОГО ЛЕЧЕНИЯ ПЕРВИЧНО-ОПЕРАБЕЛЬНОГО И МЕСТНО-РАСПРОСТРАНЕННОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Gianni L., Baselga J., Eiermann W. et al. Feasibility and tolerability of sequential doxorubicin/paclitaxel followed by cyclophosphamide, methotrexate, and fluorouracil and its effects on tumor response as preoperative therapy. Clin Cancer Res 2005;11:8715—21.</mixed-citation><mixed-citation xml:lang="ru">Gianni L., Baselga J., Eiermann W. et al. Feasibility and tolerability of sequential doxorubicin/paclitaxel followed by cyclophosphamide, methotrexate, and fluorouracil and its effects on tumor response as preoperative therapy. Clin Cancer Res 2005;11:8715—21.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Fisher B., Bryant J., Wolmark N. et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol 1998;16:2672—85.</mixed-citation><mixed-citation xml:lang="ru">Fisher B., Bryant J., Wolmark N. et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol 1998;16:2672—85.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Rastogi P., Anderson S.G., Bear H.D. et al. Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. J Clin Oncol 2008;26:778—85.</mixed-citation><mixed-citation xml:lang="ru">Rastogi P., Anderson S.G., Bear H.D. et al. Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. J Clin Oncol 2008;26:778—85.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Von Minckwitz G., Kummel S., Vogel P. et al. Neoadjuvant vinorelbine-capecitabine versus docetaxel-doxorubicin-cyclophos- phamide in early nonresponsive breast can- cer: phase III randomized GeparTrio trial. J Natl Cancer Inst 2008;100(8):521—3.</mixed-citation><mixed-citation xml:lang="ru">Von Minckwitz G., Kummel S., Vogel P. et al. Neoadjuvant vinorelbine-capecitabine versus docetaxel-doxorubicin-cyclophos- phamide in early nonresponsive breast can- cer: phase III randomized GeparTrio trial. J Natl Cancer Inst 2008;100(8):521—3.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Lazaridis G., Pentheroudakis G., Pavlidis N. Integrating trastuzumab in the neoadjuvant treatment of primary breast cancer: Accumulating evidence of efficacy, synergy and safety. Crit Rev Oncol Hematol 2008;66(1):31—41.</mixed-citation><mixed-citation xml:lang="ru">Lazaridis G., Pentheroudakis G., Pavlidis N. Integrating trastuzumab in the neoadjuvant treatment of primary breast cancer: Accumulating evidence of efficacy, synergy and safety. Crit Rev Oncol Hematol 2008;66(1):31—41.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Gralow J.R., Burstein H.J., Wood W. et al. Preoperative therapy in invasive breast cancer: Pathologic assessment and systemic therapy issues in operable dis- ease. J Clin Oncol 2008;26:814—9.</mixed-citation><mixed-citation xml:lang="ru">Gralow J.R., Burstein H.J., Wood W. et al. Preoperative therapy in invasive breast cancer: Pathologic assessment and systemic therapy issues in operable dis- ease. J Clin Oncol 2008;26:814—9.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15- year survival: an overview of the ran- domised trials. Lancet 2005;365:1687—717.</mixed-citation><mixed-citation xml:lang="ru">Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15- year survival: an overview of the ran- domised trials. Lancet 2005;365:1687—717.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. EBCTCG. New advances in the treat- ment of breast cancer. SABCS, San Antonio, TX, 2007.</mixed-citation><mixed-citation xml:lang="ru">EBCTCG. New advances in the treat- ment of breast cancer. SABCS, San Antonio, TX, 2007.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Coombes R.C., Kilburn L.S., Snowdon C.F. et al. Survival and safety of exemestane versus tamoxifen after 2—3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised con- trolled trial. Lancet 2007;369:559—70.</mixed-citation><mixed-citation xml:lang="ru">Coombes R.C., Kilburn L.S., Snowdon C.F. et al. Survival and safety of exemestane versus tamoxifen after 2—3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised con- trolled trial. Lancet 2007;369:559—70.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Jakesz R., Kaumann M., Gnant M. et al. Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and the ARNO 95 trial. Lancet 2005;366:455—62.</mixed-citation><mixed-citation xml:lang="ru">Jakesz R., Kaumann M., Gnant M. et al. Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and the ARNO 95 trial. Lancet 2005;366:455—62.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Jonat W., Gnant M., Boccardo F. et al. Effectiveness of switching from adjuvant tamoxifen to anastrozole in post- menopausal women with hormone-sensi- tive early-stage breast cancer: a meta- analysis. Lancet Oncol 2006;7:991—6.</mixed-citation><mixed-citation xml:lang="ru">Jonat W., Gnant M., Boccardo F. et al. Effectiveness of switching from adjuvant tamoxifen to anastrozole in post- menopausal women with hormone-sensi- tive early-stage breast cancer: a meta- analysis. Lancet Oncol 2006;7:991—6.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Forbes J.F., Cuzick J., Buzdar A.U. et al. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol 2008;9:45—53.</mixed-citation><mixed-citation xml:lang="ru">Forbes J.F., Cuzick J., Buzdar A.U. et al. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol 2008;9:45—53.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Buzdar A.U. Letrozole compared with tamoxifen as initial adjuvant therapy for breast cancer. J Clin Oncol 2007;25:486—92.</mixed-citation><mixed-citation xml:lang="ru">Buzdar A.U. Letrozole compared with tamoxifen as initial adjuvant therapy for breast cancer. J Clin Oncol 2007;25:486—92.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Goss P.E., Ingle J.N., Martino S. et al. Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updat- ed findings from NCIC CTG MA.17. J Natl Cancer Inst 2005;97:1262—71.</mixed-citation><mixed-citation xml:lang="ru">Goss P.E., Ingle J.N., Martino S. et al. Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updat- ed findings from NCIC CTG MA.17. J Natl Cancer Inst 2005;97:1262—71.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Mamounas E., Jeong J.-H., Wickerham L. et al. Benefit from exemestane (EXE) as extended adjuvant therapy after 5 years of tamoxifen (TAM): intent-to-treat analysis of NSABP B-33. Breast Cancer Res Treat 2006;100(Suppl 1):22. Abstr 49.</mixed-citation><mixed-citation xml:lang="ru">Mamounas E., Jeong J.-H., Wickerham L. et al. Benefit from exemestane (EXE) as extended adjuvant therapy after 5 years of tamoxifen (TAM): intent-to-treat analysis of NSABP B-33. Breast Cancer Res Treat 2006;100(Suppl 1):22. Abstr 49.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Piccart-Gebhart M.J., Procter M., Leyland-Jones H. et al. Trastuzumab after adjuvant chemotherapy in Her-2- positive breast cancer. N Engl J Med 2005;353:1659—72.</mixed-citation><mixed-citation xml:lang="ru">Piccart-Gebhart M.J., Procter M., Leyland-Jones H. et al. Trastuzumab after adjuvant chemotherapy in Her-2- positive breast cancer. N Engl J Med 2005;353:1659—72.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Perez E.A., Romond E.H., Suman V.J. et al. Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/with-out trastuzumab in patients with Her-2- positive breast cancer. ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2007;25(18):512.</mixed-citation><mixed-citation xml:lang="ru">Perez E.A., Romond E.H., Suman V.J. et al. Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/with-out trastuzumab in patients with Her-2- positive breast cancer. ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2007;25(18):512.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Slamon D., Eiermann W., Robert N. et al. Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of Her-2-positive early breast cancer patients: second interim efficacy analysis. SABCS, 2006. Abstr 209.</mixed-citation><mixed-citation xml:lang="ru">Slamon D., Eiermann W., Robert N. et al. Phase III trial comparing AC-T with AC-TH and with TCH in the adjuvant treatment of Her-2-positive early breast cancer patients: second interim efficacy analysis. SABCS, 2006. Abstr 209.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Joensuu H., Kellokumpu-Lehtinen P.-L., Bono P. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006;354:809—20.</mixed-citation><mixed-citation xml:lang="ru">Joensuu H., Kellokumpu-Lehtinen P.-L., Bono P. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006;354:809—20.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Jones S., Holmes F., O'Shaughnessy J. et al. Extended follow-up and analysis by age of the US Oncology Adjuvant trial 9735: docetaxel/cyclophosphamide is associated with an overall survival benefit compared to doxorubicin/cyclophos- phamide and is well-tolerated in women 65 or older. Breast Cancer Res Treat 2007;106(Suppl 1):5. Abstr 12.</mixed-citation><mixed-citation xml:lang="ru">Jones S., Holmes F., O'Shaughnessy J. et al. Extended follow-up and analysis by age of the US Oncology Adjuvant trial 9735: docetaxel/cyclophosphamide is associated with an overall survival benefit compared to doxorubicin/cyclophos- phamide and is well-tolerated in women 65 or older. Breast Cancer Res Treat 2007;106(Suppl 1):5. Abstr 12.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Martin M., Pienkowsky T., Mackey J. et al. Adjuvant docetaxel for node-posi- tive breast cancer. N Engl J Med 2005;352(22):2302—12.</mixed-citation><mixed-citation xml:lang="ru">Martin M., Pienkowsky T., Mackey J. et al. Adjuvant docetaxel for node-posi- tive breast cancer. N Engl J Med 2005;352(22):2302—12.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Martin M., Lluch A., SeguТ M.A. et al. Toxicity and health-related quality of life in breast cancer patients receiving adjuvant docetaxel, doxorubicin, cyclophosphamide (TAC) or 5-fluorouracil, doxorubicin and cyclophosphamide (FAC): impact of adding primary prophylactic granulocyte- colony stimulating factor to the TAC regi- men. Ann Oncol 2006;17(8):1205—12.</mixed-citation><mixed-citation xml:lang="ru">Martin M., Lluch A., SeguТ M.A. et al. Toxicity and health-related quality of life in breast cancer patients receiving adjuvant docetaxel, doxorubicin, cyclophosphamide (TAC) or 5-fluorouracil, doxorubicin and cyclophosphamide (FAC): impact of adding primary prophylactic granulocyte- colony stimulating factor to the TAC regi- men. Ann Oncol 2006;17(8):1205—12.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Hayes D.F., Thor A.D., Dressler L.G. et al. Her-2 and response to paclitaxel in node-positive breast cancer. New Engl J Med 2007;357:1496-506.</mixed-citation><mixed-citation xml:lang="ru">Hayes D.F., Thor A.D., Dressler L.G. et al. Her-2 and response to paclitaxel in node-positive breast cancer. New Engl J Med 2007;357:1496-506.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Roche H., Fumoleau P., Spielmann M. et al. Sequential adjuvant epirubicin- based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial. J Clin Oncol 2006;24(36):5664—71.</mixed-citation><mixed-citation xml:lang="ru">Roche H., Fumoleau P., Spielmann M. et al. Sequential adjuvant epirubicin- based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial. J Clin Oncol 2006;24(36):5664—71.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
