Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press31210.17650/1994-4098-2009-0-3-4-39-42MAMMOLOGY. NEW TECHNOLOGIESМАММОЛОГИЯ. НОВЫЕ ТЕХНОЛОГИИCLINICAL PERSPECTIVES FOR STUDYING THE NUCLEAR TRANSCRIPTION FACTOR NF-κB IN BREAST CANCERКЛИНИЧЕСКИЕ ПЕРСПЕКТИВЫ ИССЛЕДОВАНИЯ ЯДЕРНОГО ТРАНСКРИПЦИОННОГО ФАКТОРА NF-κВ ПРИ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫGershteinE. S.ГерштейнЕ. С.
Russian Federation
PlatovaA. M.ПлатоваА. М.
Russian Federation
alevtina-platova@mail.ruLetyaginV. P.ЛетягинВ. П.
Russian Federation
KushlinskyN. E.КушлинскийН. Е.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowГУ РОНЦ им. Н.Н. Блохина РАМН, Москва101120093-4394210092014100920142009https://ojrs.abvpress.ru/ojrs/article/view/312

The paper describes a role of the nuclear transcription factor NF-κB in oncogenesis and presents studies of this factor in breast can- cer (BC). It also shows it promising to use the values of the transcription factor NF-κB activity to identify a hormone-resistant sub- group among the patients with receptor-positive BC, in its early stages in particular.

Дано представление о роли ядерного транскрипционного фактора NF-κB в онкогенезе, приведены исследования данного фактора при раке молочной железы (РМЖ). Показана перспективность использования показателей активности транскрипционного фактора NF-κB для выявления гормонорезистентной подгруппы среди больных рецепторположительным РМЖ, особенно на ранних стадиях заболевания.

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