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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">332</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2008-0-1-20-24</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ЛЕЧЕНИЕ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">TREATMENT OF THE T3—4N0M0 BREAST CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>ЛЕЧЕНИЕ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ Т3—4N0M0 СТАДИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maximov</surname><given-names>K. V.</given-names></name><name xml:lang="ru"><surname>Максимов</surname><given-names>К. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Visotzkaya</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Высоцкая</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yermilova</surname><given-names>V. D.</given-names></name><name xml:lang="ru"><surname>Ермилова</surname><given-names>В. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Letyagin</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Летягин</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pogodina</surname><given-names>Ye. M.</given-names></name><name xml:lang="ru"><surname>Погодина</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chemeris</surname><given-names>G. Yu.</given-names></name><name xml:lang="ru"><surname>Чемерис</surname><given-names>Г. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zikiryakhodzhayev</surname><given-names>A. D.</given-names></name><name xml:lang="ru"><surname>Зикиряходжаев</surname><given-names>А. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kim</surname><given-names>Ye. A.</given-names></name><name xml:lang="ru"><surname>Ким</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Martinova</surname><given-names>G. V.</given-names></name><name xml:lang="ru"><surname>Мартынова</surname><given-names>Г. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Cancer Research Center of Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru">ГУ РОНЦ им. Н.Н. Блохина РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2008-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2008</year></pub-date><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>20</fpage><lpage>24</lpage><history><date date-type="received" iso-8601-date="2014-09-15"><day>15</day><month>09</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-09-15"><day>15</day><month>09</month><year>2014</year></date></history><permissions><copyright-year>2008</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/332">https://ojrs.abvpress.ru/ojrs/article/view/332</self-uri><abstract xml:lang="en"><p>The aim of the study was to determine the most effective regimens of the neo- and adjuvant therapy of the primary breast cancer of the T3—4N0M0 stages. The data of the clinical observations of the 145 patients with the locally advanced T3—4N0M0 breast cancer, who underwent treatment in the N.N.Blokhin CRC over the period of 1998—2003, were used in the study. The mean age of the patients was 55,3±12,9 years (from 19 to 83 years, median-55 years). The duration of the observation of the patients was 46,5±28,51 months (from 3,6 to 109,4 months, median-44,5 months). For patients with the breast cancer of the T3—4N0M0 stages combined treatment modality was implemented with the use of neo- and adjuvant therapy in all the cases.</p></abstract><trans-abstract xml:lang="ru"><p>ЛЕЧЕНИЕ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ Т3—4N0M0 СТАДИЙ</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ. М.; 2005.</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ. М.; 2005.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Давыдов М.И., Летягин В.П. Стандарты лечения больных первичным раком молочной железы. М.; 2003.</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Летягин В.П. Стандарты лечения больных первичным раком молочной железы. М.; 2003.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Возный Э.К., Добровольская Н.Ю., Гуров С.Н. Некоторые аспекты неоадъювантной терапии местнораспространенного рака молочной железы. Юбилейный сборник «Этюды химиотерапии». М.; 2000. с. 90—8.</mixed-citation><mixed-citation xml:lang="ru">Возный Э.К., Добровольская Н.Ю., Гуров С.Н. Некоторые аспекты неоадъювантной терапии местнораспространенного рака молочной железы. Юбилейный сборник «Этюды химиотерапии». М.; 2000. с. 90—8.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Летягин В.П. Первичные опухоли молочной железы. Практическое руководство по лечению. М., Миклош; 2004.</mixed-citation><mixed-citation xml:lang="ru">Летягин В.П. Первичные опухоли молочной железы. Практическое руководство по лечению. М., Миклош; 2004.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Летягин В.П., Погодина Е.М., Высоцкая И.В. и др. Лечение больных раком молочной железы стадии T2N1M0 — T3N0M0. Высокие технологии в онкологии. Материалы V Всероссийского съезда онкологов. Казань, 4—7 октября 2000 г. Т. 3. с. 55—6 (б).</mixed-citation><mixed-citation xml:lang="ru">Летягин В.П., Погодина Е.М., Высоцкая И.В. и др. Лечение больных раком молочной железы стадии T2N1M0 — T3N0M0. Высокие технологии в онкологии. Материалы V Всероссийского съезда онкологов. Казань, 4—7 октября 2000 г. Т. 3. с. 55—6 (б).</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Портной С.М., Лактионов К.П., Барканов А.И. Опыт лечения больных прогностически отягощенным местнораспространенным раком молочной железы. IV Ежегодная российская онкологическая конференция. Москва, 21—23 ноября 2000 г. с. 57—9.</mixed-citation><mixed-citation xml:lang="ru">Портной С.М., Лактионов К.П., Барканов А.И. Опыт лечения больных прогностически отягощенным местнораспространенным раком молочной железы. IV Ежегодная российская онкологическая конференция. Москва, 21—23 ноября 2000 г. с. 57—9.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Портной С.М, Лактионов К.П., Барканов А.И. Предварительные результаты органосохраняющих операций при раке молочной железы T2—3N0—2M0 после эффективной неоадьювантной терапии. Herald of the International Association of Plastic Surgeon and Oncologists, 2003;4:35.</mixed-citation><mixed-citation xml:lang="ru">Портной С.М, Лактионов К.П., Барканов А.И. Предварительные результаты органосохраняющих операций при раке молочной железы T2—3N0—2M0 после эффективной неоадьювантной терапии. Herald of the International Association of Plastic Surgeon and Oncologists, 2003;4:35.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Coskun U., Gunel N., Onuk E. et al. Effect of different neoadjuvant chemotherapy regiments on locally advanced breast cancer. Neoplasma 2003;50(3):210—6.</mixed-citation><mixed-citation xml:lang="ru">Coskun U., Gunel N., Onuk E. et al. Effect of different neoadjuvant chemotherapy regiments on locally advanced breast cancer. Neoplasma 2003;50(3):210—6.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Gajdos C., Tartter P.I., Bleiweiss I.J. et al. Stage 0 to stage III breast cancer in young women. J Am Coll Surg 2000;190(5):523—9.</mixed-citation><mixed-citation xml:lang="ru">Gajdos C., Tartter P.I., Bleiweiss I.J. et al. Stage 0 to stage III breast cancer in young women. J Am Coll Surg 2000;190(5):523—9.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Kaufmann M., Hortobagyi G.N., Goldhirsch A. et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol 2006;24:1940—9.</mixed-citation><mixed-citation xml:lang="ru">Kaufmann M., Hortobagyi G.N., Goldhirsch A. et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol 2006;24:1940—9.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Kaufmann M., von Minckwitz G., Rody A. Preoperative (neoadjuvant) sys- temic treatment of breast cancer. Breast 2005;14:576—81.</mixed-citation><mixed-citation xml:lang="ru">Kaufmann M., von Minckwitz G., Rody A. Preoperative (neoadjuvant) sys- temic treatment of breast cancer. Breast 2005;14:576—81.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Mauri D., Pavlidis N., Ioannidis J.P. Neoadjuvant versus adjuvant systemic treatment for breast cancer: a meta- analysis. J Natl Cancer Inst 2005;97:188—94.</mixed-citation><mixed-citation xml:lang="ru">Mauri D., Pavlidis N., Ioannidis J.P. Neoadjuvant versus adjuvant systemic treatment for breast cancer: a meta- analysis. J Natl Cancer Inst 2005;97:188—94.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Семиглазов В.Ф., Семиглазов В.В., Клецель А.Е. Неинвазивные и инвазивные опухоли молочной железы. С.-Пб.; 2006.</mixed-citation><mixed-citation xml:lang="ru">Семиглазов В.Ф., Семиглазов В.В., Клецель А.Е. Неинвазивные и инвазивные опухоли молочной железы. С.-Пб.; 2006.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Forguet A., Campana F., Scholl S. et al. Primary Chemotherapy of primary radiotherapy: a possibility to preserve the breast in large tumors. International Congress of Radiation Oncology 1993. June 21-25 Kyoto; 1993. p. 112.</mixed-citation><mixed-citation xml:lang="ru">Forguet A., Campana F., Scholl S. et al. Primary Chemotherapy of primary radiotherapy: a possibility to preserve the breast in large tumors. International Congress of Radiation Oncology 1993. June 21-25 Kyoto; 1993. p. 112.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Colleoni M., Litman H.J., Castiglione-Gertsch M. et al. International Breast Cancer Study Group; German Breast Cancer Study Group. Duration of adjuvant chemother- apy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF. Br J Cancer 2002;86(11):1705—14.</mixed-citation><mixed-citation xml:lang="ru">Colleoni M., Litman H.J., Castiglione-Gertsch M. et al. International Breast Cancer Study Group; German Breast Cancer Study Group. Duration of adjuvant chemother- apy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF. Br J Cancer 2002;86(11):1705—14.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Fisher E.R., Wang J., Bryant J. et al. Pathobiology of preoperative chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18. Cancer 2002;95(4):681—95.</mixed-citation><mixed-citation xml:lang="ru">Fisher E.R., Wang J., Bryant J. et al. Pathobiology of preoperative chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18. Cancer 2002;95(4):681—95.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Taghian A.G., Jeong J.H., Mamounas E.P. et al. Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel project randomized clinical trials. J Clin Oncol 2006;24(24):3927—32.</mixed-citation><mixed-citation xml:lang="ru">Taghian A.G., Jeong J.H., Mamounas E.P. et al. Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel project randomized clinical trials. J Clin Oncol 2006;24(24):3927—32.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
