Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press41410.17650/1994-4098-2014-0-4-74-82GYNECOLOGY. CLINICAL LECTUREГИНЕКОЛОГИЯ. КЛИНИЧЕСКАЯ ЛЕКЦИЯTrophoblastic diseaseТрофобластическая болезньMeshcheryakovaL. A.МещеряковаЛ. А.
Russian Federation
2010am@mail.ruN. N. Blokhin Russian Cancer Research Center, MoscowФГБНУ «РОНЦ им. Н. Н. Блохина», Москва081120144748206012015060120152014https://ojrs.abvpress.ru/ojrs/article/view/414

Trophoblastic disease encompasses a group of trophoblast abnormalities always associated with pregnancy. The urgency of studying the problemof the diagnosis and treatment of this pathology is clear because of the young age of patients, the high efficiency of treatment for malignant forms of the disease even in distant metastases and the possibility of their complete cure in 98 % of the patients with preserved reproductive function. The keystone of success is the correct and timely diagnosis of the disease and current highly effective treatment in the specialized clinic having all diagnostic facilities and successful experience in treating these patients. Clinicians» knowledge of the problem allows the avoidance of frequent errors both in the diagnosis and choice of treatment policy for patients with malignant trophoblastic tumors that may be fatal for some patients. The paper illustrates theoretical aspects with the results of treatment in patients at the N. N. Blokhin Russian Cancer Research Center that is an expert in the diagnosis and treatment of trophoblastic tumors in Russia. The paper deals with the diagnosis, treatment, and monitoring of trophoblastic disease.

Трофобластическая болезнь включает группу патологических состояний трофобласта, всегда ассоциированных с беременностью. Актуальность изучения проблемы диагностики и лечения данной патологии очевидна в связи с молодым возрастом пациенток, высокой эффективностью лечения злокачественных форм болезни даже при отдаленных метастазах и возможностью полного излечения 98 % больных с сохранением у них репродуктивной функции. Залогом успеха являются: правильная и своевременная диагностика заболевания, проведение современного высокоэффективного лечения в специализированной клинике, обладающей всеми диагностическими возможностями и имеющей успешный опыт лечения таких больных. Знание клиницистами проблемы позволит избежать нередких ошибок как в диагностике, так и в выборе тактики лечения больных злокачественными трофобластическими опухолями, которые могут оказаться для части пациенток фатальными. Статья посвящена вопросам диагностики, лечения и мониторинга трофобластической болезни. Теоретические аспекты иллюстрированы результатами лечения больных в ФГБНУ «РОНЦ им. Н. Н. Блохина», являющемся экспертом в диагностике и лечении трофобластических опухолей в России.

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