Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press44910.17650/1994-4098-2015-11-3-67-71GYNECOLOGY. DIAGNOSISГИНЕКОЛОГИЯ. ДИАГНОСТИКАRole of matrix metalloproteinase 7 in ovarian cancer (review of literature)Роль матриксной металлопротеиназы 7 при раке яичников (обзор литературы)KnyazevR. I.КнязевР. И.
Russian Federation
sluwba@mail.ruBokinI. I.БокинИ. И.
Russian Federation
BarinovV. V.БариновВ. В.
Russian Federation
Russian Medical Academy of Postgraduate Education, Ministry of Health of RussiaГБОУ ДПО РМАПО Минздрава России2/1 Barrikadnaya St., Moscow, 123995, RussiaРоссия, 123995, Москва, ул. Баррикадная, 2/1Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia2/1 Barrikadnaya St., Moscow, 123995, RussiaГБОУ ДПО РМАПО Минздрава РоссииРоссия, 123995, Москва, ул. Баррикадная, 2/1N.N. Blokhin Russian Cancer Research Center23 Kashirskoe Shosse, Moscow, 115478, RussiaФГБНУ «РОНЦ им. Н.Н. Блохина»Россия, 115478, Москва, Каширское шоссе, 231609201511367711509201515092015https://ojrs.abvpress.ru/ojrs/article/view/449

Ovarian carcinoma is one of the most aggressive cancer in women, and one of the leading causes of death from cancer of the reproductive system. Despite enhancement methods of prevention, early diagnosis, treatment, such as surgery, radiation, drugs, including targeted and hormone therapy, long-term results remain unsatisfactory. In this connection, much attention is paid to the search for molecular biological mechanisms involved in carcinogenesis and the development of laboratory tests for detecting patients at early stages of tumor process, to differentiate malignant and benign tumors, to determine the tactics of treatment of a particular patient, to assess the prognosis. One of the key aspects of the pathogenesis of ovarian cancer is the interaction of tumor tissue extracellular matrix, the protein degradation of which in most cases is controlled by proteolytic enzymes. Matrix metalloproteinase 7 (MMP-7), also known as matrilysin, like other members of the matrix metalloproteinase` family, demonstrates proteolytic activity against components of the extracellular matrix, the degradation of which is the basis of cancer invasion and metastasis. Matrilysin is also involved in the regulation of activities of bioactive molecules associated with cell physiology. The overview briefly highlights the role of MMP-7 in ovarian cancer. 

Рак яичников является одним из наиболее агрессивных опухолевых заболеваний у женщин и стойко занимает одно из ведущих мест среди причин смертности от онкологической патологии репродуктивной системы. Несмотря на совершенствование способов профилактики, ранней диагностики, а также наличие в арсенале онкологов современных методов лечения, включающих хирургический, лучевой, лекарственный, в том числе таргетную и гормонотерапию, отдаленные результаты остаются неудовлетворительными. В связи с этим большое внимание уделяется поиску молекулярно-биологических механизмов, участвующих в канцерогенезе, а также разработке лабораторных тестов, позволяющих выявить больных на ранних стадиях опухолевого процесса, дифференцировать злокачественные и доброкачественные опухоли, определить тактику лечения конкретного пациента и оценить прогноз. Одним из ключевых моментов этиопатогенеза рака яичников является взаимодействие опухолевой ткани с межклеточным веществом, распад протеинов которого в большинстве случаев контролируется протеолитическими ферментами. Матриксная металлопротеиназа 7 (ММП-7), или матрилизин, как и другие представители семейства ММП, проявляет протеолитическую активность в отношении компонентов межклеточного пространства, деградация которых лежит в основе механизмов инвазии и метастазирования опухолевых клеток. Матрилизин участвует также в регуляции биоактивных молекул, принимающих непосредственное участие в физиологии клетки. В обзоре кратко освещена роль ММП-7 при раке яичников. 

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