Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press47510.17650/1994-4098-2016-12-1-46-51MAMMOLOGY. TREATMENTМАММОЛОГИЯ. ЛЕЧЕНИЕRole of targeted therapy in the treatment of HER-2-positive breast cancer brain metastasesРоль таргетной терапии в лечении метастатического HER-2-положительного рака молочной железы с поражением головного мозгаDashyanG. A.ДашянГ. А.
Russian Federation
dgarik@mail.ruSemiglazovV. F.СемиглазовВ. Ф.
Russian Federation
Krivorot’koP. V.КриворотькоП. В.
Russian Federation
SemiglazovaT. Yu.СемиглазоваТ. Ю.
Russian Federation
TopuzovE. E.ТопузовЭ. Э.
Russian Federation
PaltuevR. M.ПалтуевР. М.
Russian Federation
ZernovK. Yu.ЗерновК. Ю.
Russian Federation
ApollonovaV. S.АполлоноваВ. С.
Russian Federation
EreshchenkoS. S.ЕрещенкоС. С.
Russian Federation
PetrovaA. V.ПетроваА. В.
Russian Federation
Zhil’tsovaE. K.ЖильцоваЕ. К.
Russian Federation
IvanovaO. A.ИвановаО. А.
Russian Federation
N.N. Petrov Research Institute of Oncology, Ministry of Health of RussiaФГБУ «Научно-исследовательский институт онкологии им. Н.Н. Петрова» Минздрава России68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, RussiaРоссия, 197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68I.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России41 Kirochnaya St., Saint Petersburg, 191015, RussiaРоссия, 191015, Санкт-Петербург, ул. Кирочная, 410606201612146510606201606062016https://ojrs.abvpress.ru/ojrs/article/view/475

Brain metastases are detectable in 25–35 % of patients with progressive HER-2-positve breast cancer. Even after spreading metastases into the brain, chemotherapy in combination with anti-HER- 2 therapy improves survival due to better control of the systemic disease. The paper presents the results of investigations substantiating the use of anti-HER-2 targeting agents, as well as the innovative agent T-DM1 to treat brain metastases.

При прогрессировании HER-2-положительного рака молочной железы метастазы в головной мозг выявляются у 25–35 % больных. Сочетание химиотерапии с анти-HER-2-терапией повышает выживаемость даже после развития метастазов в головной мозг благодаря улучшению контроля системного заболевания. В статье представлены результаты исследований, обосновывающие использование таргетных анти-HER-2-препаратов, а также инновационного препарата T-DM1 при метастатическом поражении головного мозга.

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