Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press49210.17650/1994-4098-2016-12-2-35-45MAMMOLOGY. ORIGINAL ARTICLEМАММОЛОГИЯ. ОРИГИНАЛЬНАЯ СТАТЬЯPlace of pegylated liposomal doxorubicin in the therapy of metastatic breast cancerМесто пегилированного липосомального доксорубицина в терапии метастатического рака молочной железыArtamonovaE. V.АртамоноваЕ. В.
Russian Federation
artamonovae@mail.ruN.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «РОНЦ им. Н. Н. Блохина» Минздрава России1109201612235451109201611092016https://ojrs.abvpress.ru/ojrs/article/view/492

The review deals with trials of pegylated liposomal doxorubicin (PLD) used to treat metastatic breast cancer (mBC), including first-line monotherapy, maintenance therapy, combinations with other cytostatics, trastuzumab regimens for a HER-2-positive subvariant, and rescue therapy for intensively pretreated forms of the disease. PLD is shown to be highly competitive with conventional anthracyclines in efficacy and to greatly surpass them in safety particularly in patients at high cardiac risk; the lack of cumulative toxicity and maximum allowable dose makes it possible to perform therapy until the disease progresses, to use the drug as a support, and to effectively and safely combine PLD with trastuzumab in HER-2-positive mBC. A clinical benefit from the administration of PLD does not depend on susceptibility to anthracyclines. The drug is also an important treatment option for taxane-refractory mBC.

Обзор посвящен исследованиям пегилированного липосомального доксорубицина (ПЛД) при метастатическом раке молочной железы (мРМЖ), включая монотерапию 1-й линии, «поддерживающую» терапию, комбинации с другими цитостатиками, режимы с трастузумабом при HER-2-позитивном подварианте, а также «терапию спасения» при интенсивно предлеченных формах заболевания. Показано, что ПЛД не уступает обычным антрациклинам по эффективности и значительно превосходит их по безопасности, особенно у больных с высоким риском кардиальных осложнений; отсутствие кумулятивной токсичности и предельно допустимой дозы позволяет проводить терапию до прогрессирования, использовать препарат в качестве «поддержки», а также эффективно и безопасно комбинировать ПЛД с трастузумабом при HER-2-позитивном мРМЖ. Клиническая польза от назначения ПЛД не зависит от чувствительности к обычным антрациклинам. Препарат является также важной опцией лечения таксан-рефрактерного мРМЖ.

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