Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press5010.17650/1994-4098-2013-0-3-4-12-17MAMMOLOGY. TOPICAL ISSUEМАММОЛОГИЯ. АКТУАЛЬНАЯ ТЕМАRole of a cyclooxygenase-2 cascade in breast cancer cell disseminationРоль каскада циклооксигеназы-2 в метастазировании рака молочной железыTaipovM. A.ТаиповМ. А.
Russian Federation
taipoff.m@yandex.ruKudryavtsevI. A.КудрявцевИ. А.
Russian Federation
LaktionovK. P.ЛактионовК. П.
Russian Federation
LevchenkoN. E.ЛевченкоН. Е.
Russian Federation
ShevchenkoV. E.ШевченкоВ. Е.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва220920133-4121722072014220720142013https://ojrs.abvpress.ru/ojrs/article/view/50

Current therapeutic approaches based on a study of the genetic portrait of a tumor individualize treatment policy to a greater extent, which cre- ates real prospects for the increasing number of patients to recover. Experimental and clinical evidence suggest that the increased expression of the COX-2 gene increases the risk for breast cancer (BC) cell dissemination into distant organs. A number of recent studies have revealed that selec- tive COX-2 inhibitors are able to suppress proliferation, to induce apoptosis in the BC cells, and to inhibit tumor neoangiogenesis. However, this area contains many unclear and disputable problems to be still experimentally solved. Our review deals with the theoretical prerequisites for and the analysis of a role of COX-2 in BC cell dissemination.

Современные подходы в терапии, основанные на изучении генетического портрета опухоли, все сильнее индивидуализируют ле- чебную тактику, что создает реальные перспективы выздоровления все большего числа пациенток. Экспериментальные и кли- нические данные показали, что повышенная экспрессия гена СОХ-2 увеличивает риск метастазирования рака молочной железы (РМЖ) в отдаленные органы. В ряде исследований последних лет обнаружено, что селективные ингибиторы фермента СОХ-2 способны тормозить пролиферацию, индуцировать апоптоз клеток РМЖ и угнетать неоангиогенез в опухоли. Однако в этой области много неясных и спорных вопросов, экспериментальное решение которых еще впереди. Наш обзор посвящен теоретическим предпосылкам и анализу результатов исследований роли COX-2 в метастазировании РМЖ.

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