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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">512</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2016-12-3-80-86</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Problems of diagnostics and treatment of uterine tube cancer (clinical case)</article-title><trans-title-group xml:lang="ru"><trans-title>Проблемы диагностики и лечения рака маточной трубы (клинический случай)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Levchenko</surname><given-names>N. E.</given-names></name><name xml:lang="ru"><surname>Левченко</surname><given-names>Н. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478,</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><email>levch.1975@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mushtenko</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Муштенко</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478,</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Savostikova</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Савостикова</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478,</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>T. I.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>Т. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478,</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «РОНЦ им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-11-24" publication-format="electronic"><day>24</day><month>11</month><year>2016</year></pub-date><volume>12</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>80</fpage><lpage>86</lpage><history><date date-type="received" iso-8601-date="2016-11-24"><day>24</day><month>11</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-11-24"><day>24</day><month>11</month><year>2016</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/512">https://ojrs.abvpress.ru/ojrs/article/view/512</self-uri><abstract xml:lang="en"><p>The clinical case of seldom found pathology – primary cancer of the uterine tube including at the same time both epithelial and sarcomatous component of a tumor is described. Data on a cancer of a uterine tube which, being a rare tumor are submitted, is morphologically similar to an ovary carcinoma. Predictively significant factors for this tumor are the disease stage, volume of residual tumoral masses, SA-125 indicators, and also as those the vascular invasion, degree of a differentiation of a tumor and age of patients are considered. On the basis of our supervision and clinical experience we came to a conclusion that this clinical case emphasizes not specificity of a current and complexity of timely diagnosis of a disease. Thus, an actual task is research of this problem for the purpose of improvement of quality of early diagnosis of primary cancer of uterine tube and use of new modern methods of treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Клиническое наблюдение редкой первичной эпителиально-мезенхимальной злокачественной опухоли маточной трубы и трудности ее дооперационной диагностики и последующего лечения легли в основу представленной статьи. Сопоставление собственных данных с международным опытом показало, что прогностически значимыми факторами для таких пациенток будут являться: возраст, стадия заболевания, объем остаточных опухолевых масс, уровень СА-125, степень сосудистой инвазии и дифференцировки эпителиального компонента. Проведенный анализ демонстрирует сложность ранней диагностики злокачественных новообразований маточных труб и непредсказуемость роста опухолей смешанного типа. В связи с этим мы считаем, что разбор особенностей редких морфологических форм опухолей является актуальным для расширения клинического опыта врачей.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cancer of uterine tube</kwd><kwd>sarcoma of uterine tube</kwd><kwd>carcinosarcoma</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак маточной трубы</kwd><kwd>саркома маточной трубы</kwd><kwd>карциносаркома</kwd><kwd>диагностика</kwd><kwd>лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Давыдов М.И., Аксель Е.М. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2008 г. Вестник РОНЦ 2010;21(2 прил. 1):52–86. [Davydov М.I., Аksel’ Е.М. Malignant tumors’ morbidity of the population of Russia and of CIS countries in 2008. RCRC Herald 2010;21(2 Suppl 1):52–86. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2008 г. Вестник РОНЦ 2010;21(2 прил. 1):52–86. [Davydov М.I., Аksel’ Е.М. Malignant tumors’ morbidity of the population of Russia and of CIS countries in 2008. RCRC Herald 2010;21(2 Suppl 1):52–86. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Greenlee R.T., Murray T., Bolden S., Wingo P.A. Cancer statistics, 2000. CA Cancer J Clin 2000;50(1):7–33. PMID: 10735013.</mixed-citation><mixed-citation xml:lang="ru">Greenlee R.T., Murray T., Bolden S., Wingo P.A. Cancer statistics, 2000. CA Cancer J Clin 2000;50(1):7–33. PMID: 10735013.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Лазарева Н.И., Кузнецов В.В., Захарова Т.И. Саркомы. В кн.: Клиническая онкогинекология. Руководство для врачей. Под ред. В.П. Казаченко. М.: Медицина, 2005. С. 178–220. [Lazarevа N.I., Kuznetsov V.V., Zakharovа Т.I. Sarcomas. In: Clinical oncogynecology. Guidelines for physicians. Ed. by V.P. Kazachenko. Мoscow: Меditsina, 2005. Pp. 178–220. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Лазарева Н.И., Кузнецов В.В., Захарова Т.И. Саркомы. В кн.: Клиническая онкогинекология. Руководство для врачей. Под ред. В.П. Казаченко. М.: Медицина, 2005. С. 178–220. [Lazarevа N.I., Kuznetsov V.V., Zakharovа Т.I. Sarcomas. In: Clinical oncogynecology. Guidelines for physicians. Ed. by V.P. Kazachenko. Мoscow: Меditsina, 2005. Pp. 178–220. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Laury A.R., Ning G., Quick C.M. et al. Fallopian tube correlates of ovarian serous borderline tumors. Am J Surg Pathol 2011;35(12):1759–65. DOI: 10.1097/PAS.0b013e318233b0f7. PMID: 22089527.</mixed-citation><mixed-citation xml:lang="ru">Laury A.R., Ning G., Quick C.M. et al. Fallopian tube correlates of ovarian serous borderline tumors. Am J Surg Pathol 2011;35(12):1759–65. DOI: 10.1097/PAS.0b013e318233b0f7. PMID: 22089527.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Hu C., Taymor M., Hertig A. Primary carcinoma of the fallopian tube. Am J Obstet Gynecol 1950;59(1):58–67. PMID: 15399626.</mixed-citation><mixed-citation xml:lang="ru">Hu C., Taymor M., Hertig A. Primary carcinoma of the fallopian tube. Am J Obstet Gynecol 1950;59(1):58–67. PMID: 15399626.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Berek J.S., Hacker N.F. Practical Gynaecologic Oncology. 4th edn. Lippincott Williams and Wilkins, 2005. Pp. 511–41.</mixed-citation><mixed-citation xml:lang="ru">Berek J.S., Hacker N.F. Practical Gynaecologic Oncology. 4th edn. Lippincott Williams and Wilkins, 2005. Pp. 511–41.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Chen C., Li J., Yao G. et al. Tubal origin of ovarian low-grade serous carcinoma. Am J Clin Exp Obstet Gynecol 2013;1(1):13–36. PMID: 25346935.</mixed-citation><mixed-citation xml:lang="ru">Chen C., Li J., Yao G. et al. Tubal origin of ovarian low-grade serous carcinoma. Am J Clin Exp Obstet Gynecol 2013;1(1):13–36. PMID: 25346935.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Bodurka D.C., Gershenson D.M. Sarcomas of reproductive tract. Atlas Clin Oncol Soft Tissue Sarcomas 2002;15: 213–27.</mixed-citation><mixed-citation xml:lang="ru">Bodurka D.C., Gershenson D.M. Sarcomas of reproductive tract. Atlas Clin Oncol Soft Tissue Sarcomas 2002;15: 213–27.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Eddie S.L., Quartuccio S.M., MoyleHeyrman G. et al. Tumorigenesis and peritoneal colonization from fallopian tube epithelium. Oncotarget 2015;6(24):20500–12. DOI: 10.18632/oncotarget.3985. PMID: 25971410.</mixed-citation><mixed-citation xml:lang="ru">Eddie S.L., Quartuccio S.M., MoyleHeyrman G. et al. Tumorigenesis and peritoneal colonization from fallopian tube epithelium. Oncotarget 2015;6(24):20500–12. DOI: 10.18632/oncotarget.3985. PMID: 25971410.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Imachi M., Tsukamoto N., Shigematsu T. et al. Malignant mixed Mullerian tumor of the fallopian tube: report of two cases and review of literature. Gynecol Oncol 1992;47(1):114–24. PMID: 1330846.</mixed-citation><mixed-citation xml:lang="ru">Imachi M., Tsukamoto N., Shigematsu T. et al. Malignant mixed Mullerian tumor of the fallopian tube: report of two cases and review of literature. Gynecol Oncol 1992;47(1):114–24. PMID: 1330846.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Gagner J.P., Mittal K. Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. Gynecol Oncol 2005;97(1): 219–22. DOI: 10.1016/j.ygyno.2004.11.053. PMID: 15790462.</mixed-citation><mixed-citation xml:lang="ru">Gagner J.P., Mittal K. Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. Gynecol Oncol 2005;97(1): 219–22. DOI: 10.1016/j.ygyno.2004.11.053. PMID: 15790462.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Mundkur A., Rai L., Hebbar S. et al. Fallopian tube choriocarcinoma presenting as ovarian tumour: a case report. J Clin Diagn Res 2015;9(1):QD01–2. DOI: 10.7860/JCDR/2015/9018.5359. PMID: 25738040.</mixed-citation><mixed-citation xml:lang="ru">Mundkur A., Rai L., Hebbar S. et al. Fallopian tube choriocarcinoma presenting as ovarian tumour: a case report. J Clin Diagn Res 2015;9(1):QD01–2. DOI: 10.7860/JCDR/2015/9018.5359. PMID: 25738040.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Leppien G. Non-uterine gynecological sarcomas. Arch Gynecol Obstet 1987;241(1):25–32. PMID: 3314737.</mixed-citation><mixed-citation xml:lang="ru">Leppien G. Non-uterine gynecological sarcomas. Arch Gynecol Obstet 1987;241(1):25–32. PMID: 3314737.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Mariani L., Quattrini M., Galati M. et al. Primary leiomyosarcoma of the fallopian tube: A case report. Eur J Gynaecol Oncol 2005;26(3):333–5. PMID: 15991540.</mixed-citation><mixed-citation xml:lang="ru">Mariani L., Quattrini M., Galati M. et al. Primary leiomyosarcoma of the fallopian tube: A case report. Eur J Gynaecol Oncol 2005;26(3):333–5. PMID: 15991540.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Lim B.J., Kim J.W., Yang W.I. et al. Malignant mixed mullerian tumor of fallopian tube with multiple distinct heterologous components. Int J Gynecol Cancer 2004;14(4):690–3. DOI: 10.1111/j.1048-891X.2004.14432.x. PMID: 15304169.</mixed-citation><mixed-citation xml:lang="ru">Lim B.J., Kim J.W., Yang W.I. et al. Malignant mixed mullerian tumor of fallopian tube with multiple distinct heterologous components. Int J Gynecol Cancer 2004;14(4):690–3. DOI: 10.1111/j.1048-891X.2004.14432.x. PMID: 15304169.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Horn L.C., Werschnik C., Bilek K., Emmert C. Diagnosis and clinical management in malignant Mullerian tumors of the fallopian tube. Arch Gynecol Obstet 1996;258(1): 47–53. PMID: 8789433.</mixed-citation><mixed-citation xml:lang="ru">Horn L.C., Werschnik C., Bilek K., Emmert C. Diagnosis and clinical management in malignant Mullerian tumors of the fallopian tube. Arch Gynecol Obstet 1996;258(1): 47–53. PMID: 8789433.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Le T., Krepart G.V., Lotocki R.J., Heywood M.S. Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20 year experience. Gynecol Oncol 1997;65(2):237–40. DOI: 10.1006/gyno.1997.4625. PMID: 9159331.</mixed-citation><mixed-citation xml:lang="ru">Le T., Krepart G.V., Lotocki R.J., Heywood M.S. Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20 year experience. Gynecol Oncol 1997;65(2):237–40. DOI: 10.1006/gyno.1997.4625. PMID: 9159331.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Kurman R.J., Carcangiu M.L., Herrington C.S., Young R.H. World Health Organization classification of Tumours of Female Reproductive Organs. 4th edn. Lyon: IARC Press, 2014. 307 p.</mixed-citation><mixed-citation xml:lang="ru">Kurman R.J., Carcangiu M.L., Herrington C.S., Young R.H. World Health Organization classification of Tumours of Female Reproductive Organs. 4th edn. Lyon: IARC Press, 2014. 307 p.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Prat J. Ovarian, fallopian tube and peritoneal cancer staging: Rationale and explanation of new FIGO staging 2013. Best Pract Res Clin Obstet Gynaecol 2015;29(6):858–69. DOI: 10.1016/j.bpobgyn.2015.03.006. PMID: 25890882.</mixed-citation><mixed-citation xml:lang="ru">Prat J. Ovarian, fallopian tube and peritoneal cancer staging: Rationale and explanation of new FIGO staging 2013. Best Pract Res Clin Obstet Gynaecol 2015;29(6):858–69. DOI: 10.1016/j.bpobgyn.2015.03.006. PMID: 25890882.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Ryu K.J., Kim I.S., Bae H.S. et al. Paratubal cancer found at the time of laparoscopic surgery for adnexal torsion: a case report and literature review. Eur J Gynaecol Oncol 2014;35(6):741–4. PMID: 25556286.</mixed-citation><mixed-citation xml:lang="ru">Ryu K.J., Kim I.S., Bae H.S. et al. Paratubal cancer found at the time of laparoscopic surgery for adnexal torsion: a case report and literature review. Eur J Gynaecol Oncol 2014;35(6):741–4. PMID: 25556286.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Singh N., Gilks C.B., Wilkinson N., McCluggage W.G. Assessment of a new system for primary site assignment in highgrade serous carcinoma of the fallopian tube, ovary, and peritoneum. Histopathology 2015;67(3):331–7. DOI: 10.1111/his.12651. PMID: 25640750.</mixed-citation><mixed-citation xml:lang="ru">Singh N., Gilks C.B., Wilkinson N., McCluggage W.G. Assessment of a new system for primary site assignment in highgrade serous carcinoma of the fallopian tube, ovary, and peritoneum. Histopathology 2015;67(3):331–7. DOI: 10.1111/his.12651. PMID: 25640750.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
