Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press52310.17650/1994-4098-2016-12-4-37-46MAMMOLOGY. REVIEWМАММОЛОГИЯ. ОБЗОРPaget’s disease of the breast (a review of literature)Рак Педжета молочной железы (обзор литературы)NikitinaE. A.НикитинаЕ. А.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

katuwa689@yandex.ruNechushkinM. I.НечушкинМ. И.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

TrigolosovA. V.ТриголосовА. В.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

VishnevskayaYa. V.ВишневскаяЯ. В.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России10122016124374609022017090220172016https://ojrs.abvpress.ru/ojrs/article/view/523

Paget’s disease (PD) of the nipple is a rare form of breast cancer, characterized by erythema, an scaling of the skin and eczematous changes of the nipple-areolar complex. Despite a significant increase in newly detected cases of breast cancer, PD is accounting for 0.5–5.0 % of all breast tumors in the world. In female patients with PD ages range from 24 to 90 years (average age range 50–60 years), predominantly menopausal age in 70 % of cases. But cases of PD in young person were reported.

Currently, the relevance of the PD of the nipple is preserved. There are different methods of treatment, but we haven’t specific international recommendations for treatment PD in surgery, irradiation and chemotherapy or target therapy. There are small numbers of randomized studies of PD. The use of modern methods of instrumental and molecular diagnostics can help designed algorithm the treatment of PD.

In this literature review the etiology, clinical features and current approaches to diagnosis and possible treatment of PD of the nipple.

Рак Педжета (РП) – редко встречающееся заболевание молочной железы, характеризующееся такими клиническими симптомами, как эритема, мацерация и экзематозные изменения сосково-ареолярного комплекса. Несмотря на значительный прирост числа вновь выявленных случаев рака молочной железы, статистика по РП остается стабильной – 0,5–5,0 % от общего числа заболевших в мире. Болеют женщины 24–90 лет (средний возраст 50–60 лет), преимущественно менопаузального возраста (70 %), хотя выявлены случаи РП и у подростков.

В настоящее время актуальность темы РП соска сохраняется, до сих пор ведутся споры о возможных способах его лечения. На данный момент нет выделенных международных рекомендаций по объему хирургического лечения, необходимости облучения и проведения таргетной или химиотерапии при данном заболевании. Редкость РП обусловливает малое количество крупных рандомизированных исследований, посвященных этой тематике, поэтому дальнейшее накопление материала, использование современных методов инструментальной и молекулярной диагностики позволит и дальше оптимизировать алгоритм лечения данной нозологии, что положительно скажется на отдаленных результатах.

В данном обзоре литературы освещены этиология, особенности клинического течения и современные подходы к диагностике и возможному лечению РП соска.

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