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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">530</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2017-13-1-14-19</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pharmacological effects and molecular mechanisms of action of a herbal medicine based on Vitex agnus-castus</article-title><trans-title-group xml:lang="ru"><trans-title>Фармакологические эффекты и молекулярные механизмы действия лечебного фитопрепарат а на основе Vitex agnus-castus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vysotskaya</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Высоцкая</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>vysotskaya.irina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Letyagin</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Летягин</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-05-05" publication-format="electronic"><day>05</day><month>05</month><year>2017</year></pub-date><volume>13</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>14</fpage><lpage>19</lpage><history><date date-type="received" iso-8601-date="2017-05-05"><day>05</day><month>05</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-05-05"><day>05</day><month>05</month><year>2017</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/530">https://ojrs.abvpress.ru/ojrs/article/view/530</self-uri><abstract xml:lang="en"><p>Dyshormonal breast dysplasia is the most frequent pathology encountered by practitioners. The interest of clinicians to these processes is associated with several factors. On the one hand effective treatment, relieves symptoms, ensures the quality of life. On the other hand, mastitis is a risk factor for subsequent malignant tumor. Therefore, timely correction is a variant of primary prevention of breast cancer. The choice of the adequate tactics of conducting such patients from the existing diversity of dosage forms is the key to success. The paper discusses the main molecular mechanisms that are implemented with the use of the drug Mastodynon.</p></abstract><trans-abstract xml:lang="ru"><p>Дисгормональные дисплазии молочных желез – самая частая патология, с которой встречаются практикующие врачи. Интерес клиницистов к данным процессам связан с несколькими обстоятельствами. С одной стороны, эффективное лечение, купирующеесимптомы, гарантирует качество жизни. С другой стороны, мастопатия – фактор риска развития в дальнейшем злокачественной опухоли. Поэтому своевременная коррекция дисплазии может рассматриваться как вариант первичной профилактики рака молочных желез. Выбор адекватной тактики ведения подобных пациентов из многообразия существующих лекарственных форм – залог успеха лечения.Статья посвящена рассмотрению основных молекулярных механизмов действия, которые реализуются при использовании препарата Мастодинон.</p></trans-abstract><kwd-group xml:lang="en"><kwd>dishormonal dysplasia</kwd><kwd>mastalgia</kwd><kwd>mastopathy</kwd><kwd>mastodynia</kwd><kwd>hyperprolactinemia</kwd><kwd>opioid receptors</kwd><kwd>receptors to estrogens</kwd><kwd>dopamine receptors</kwd><kwd>Mastodynon</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дисгормональная дисплазия</kwd><kwd>масталгия</kwd><kwd>мастопатия</kwd><kwd>мастодиния</kwd><kwd>гиперпролактинемия</kwd><kwd>опиоидные рецепторы</kwd><kwd>рецепторы эстрогенов</kwd><kwd>дофаминовые рецепторы</kwd><kwd>Мастодинон</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Высоцкая И. 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