Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press54610.17650/1994-4098-2017-13-2-75-84GYNECOLOGY. CLINICAL CASEГИНЕКОЛОГИЯ. КЛИНИЧЕСКИЙ СЛУЧАЙSMALL CELL CARCINOMA OF THE VAGINA (LITERATURE REVIEW AND CLINICAL OBSERVATIONS)МЕЛКОКЛЕТОЧНЫЙ РАК ВЛАГАЛИЩА (ОБЗОР ЛИТЕРАТУРЫ И КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ)TagibovaT. Sh.ТагибоваТ. Ш.
Russian Federation

24 Kashira Highway, Moscow 115478

Тамилия Шахабудиновна Тагибова.

115478 Москва, Каширское шоссе, 24

wokolad05@yandex.ruNikogosyanS. O.НикогосянС. О.
Russian Federation

24 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 24

KuznetsovV. V.КузнецовВ. В.
Russian Federation

24 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 24

AnurovaO. A.АнуроваО. А.
Russian Federation

24 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 24

IvanovA. M.ИвановА. М.
Russian Federation

24 Kashira Highway, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России2806201713275842906201729062017https://ojrs.abvpress.ru/ojrs/article/view/546

Small cell carcinoma of the vagina is a very rare manifestation of neuroendocrine tumors. In the article, a review of literature on this problem and description of the clinical course and treatment of small cell carcinoma of the vagina from 3 our observations are presented. Personalized approach and combination treatment are, in our opinion, the main principles of treatment of these patients.

Мелкоклеточный рак влагалища крайне редкое проявление нейроэндокринных опухолей. В статье представлен обзор мировой литературы по этой проблеме, а также описание клинического течения и лечения мелкоклеточного рака влагалища 3 собственных наблюдений. Индивидуальный подход и комбинированное лечение, на наш взгляд, это основные принципы терапии этой категории больных.

small cell carcinoma of the vaginatreatment methodsмелкоклеточный рак влагалищаметоды лечения1. Albores-Saavedra J. Primary carcinoid of the uterine cervix. Pathologia 1972;10:185–93.Albores-Saavedra J. Primary carcinoid of the uterine cervix. Pathologia 1972;10:185–93.2. Scully R.E.; Aguirre P., DeLellis R.A. Argyrophilia, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 1984;3:51–70. PMID: 6145674.Scully R.E.; Aguirre P., DeLellis R.A. Argyrophilia, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 1984;3:51–70. PMID: 6145674.3. Cohen J.G., Chan J.K., Kapp D.S. The management of small-cell carcinomas of the gynecologic tract. Curr Opin Oncol 2012;24:572–9. DOI: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410.Cohen J.G., Chan J.K., Kapp D.S. The management of small-cell carcinomas of the gynecologic tract. Curr Opin Oncol 2012;24:572–9. DOI: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410.4. Tamura R., Yokoyama Y., Kobayashi A. et al. A case of small cell carcinoma of the vagina. Rare Tumors 2013;5: e58. DOI:10.4081/rt.2013.e58. PMID:24416492.Tamura R., Yokoyama Y., Kobayashi A. et al. A case of small cell carcinoma of the vagina. Rare Tumors 2013;5: e58. DOI:10.4081/rt.2013.e58. PMID:24416492.5. Oliveira R., Bocoli M.C. et al. Primary Small Cell Carcinoma of the Vagina. Case Reports in Obstetrics and Gynecology 2013;2013:4. DOI: 10.1155/2013/827037. PMID: 23878751.Oliveira R., Bocoli M.C. et al. Primary Small Cell Carcinoma of the Vagina. Case Reports in Obstetrics and Gynecology 2013;2013:4. DOI: 10.1155/2013/827037. PMID: 23878751.6. Brennan S.M., Gregory D.L., Stillie A. et al. Should extrapulmonary small cell cancer be managed like small cell lung cancer? Cancer 2010;116:888–95. DOI: 10.1002/cncr.24858. PMID: 20052730.Brennan S.M., Gregory D.L., Stillie A. et al. Should extrapulmonary small cell cancer be managed like small cell lung cancer? Cancer 2010;116:888–95. DOI: 10.1002/cncr.24858. PMID: 20052730.7. Duguid J., Kennedy A. Oat cell tumors of mediastinal glands. J Pathol Bacteriol 1930;33:93–99.Duguid J., Kennedy A. Oat cell tumors of mediastinal glands. J Pathol Bacteriol 1930;33:93–99.8. Petru E., Pasterk C., Reich O. et al. Small-cell carcinoma of the uterus and the vagina: experience with ten patients. Arch Gynecol Obstet 2005;271:316–9. DOI: 10.1007/s00404-004-0630-1. PMID: 15197564.Petru E., Pasterk C., Reich O. et al. Small-cell carcinoma of the uterus and the vagina: experience with ten patients. Arch Gynecol Obstet 2005;271:316–9. DOI: 10.1007/s00404-004-0630-1. PMID: 15197564.9. Hayashi M., Mori Y., Takagi Y. et al. Primary small cell neuroendocrine carcinoma of the vagina. Marked effect of combination chemotherapy: a case report. Oncology 2000;58:300–4. DOI: 12116. PMID: 10838495.Hayashi M., Mori Y., Takagi Y. et al. Primary small cell neuroendocrine carcinoma of the vagina. Marked effect of combination chemotherapy: a case report. Oncology 2000;58:300–4. DOI: 12116. PMID: 10838495.10. Singh V., Singh H., Leong C. et al. Vaginal small cell carcinoma: case report and review of literature. N Y Med J 2008.Singh V., Singh H., Leong C. et al. Vaginal small cell carcinoma: case report and review of literature. N Y Med J 2008.11. Prasad C.J., Ray J.A., Kessler S. Primary small cell carcinoma of the vagina arising in a background of atypical adenosis. Cancer 1992;70:2484–7. PMID: 1330282.Prasad C.J., Ray J.A., Kessler S. Primary small cell carcinoma of the vagina arising in a background of atypical adenosis. Cancer 1992;70:2484–7. PMID: 1330282.12. Slotman B., Faivre-Finn C., Kramer G. et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med 2007;357:664–72. DOI: 10.1056/NEJMoa071780. PMID: 17699816.Slotman B., Faivre-Finn C., Kramer G. et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med 2007;357:664–72. DOI: 10.1056/NEJMoa071780. PMID: 17699816.13. Gardner G.J., Reidy-Lagunes D., Gehrig P.A. Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. Gynecol Oncol 2011;122:190–8. DOI: 10.1016/j.ygyno.2011.04.011. PMID: 21621706.Gardner G.J., Reidy-Lagunes D., Gehrig P.A. Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. Gynecol Oncol 2011;122:190–8. DOI: 10.1016/j.ygyno.2011.04.011. PMID: 21621706.14. Wajchenberg B.L., Mendonca B.B., Liberman B. et al. Ectopic adreno-corticotropic hormone syndrome. Endocr Rev 1994;15:752–87. DOI: 10.1210/edrv-15-6-752. PMID: 7705280.Wajchenberg B.L., Mendonca B.B., Liberman B. et al. Ectopic adreno-corticotropic hormone syndrome. Endocr Rev 1994;15:752–87. DOI: 10.1210/edrv-15-6-752. PMID: 7705280.15. Colleran K.M., Burge M.R., Crooks L.A., Dorin R.I. Small cell carcinoma of the vagina causing Cushing’s syndrome by ectopic production and secretion of ACTH: a case report. Gynecol Oncol 1997;65:526–9. DOI: 10.1006/gyno1997.4701. PMID: 9190988.Colleran K.M., Burge M.R., Crooks L.A., Dorin R.I. Small cell carcinoma of the vagina causing Cushing’s syndrome by ectopic production and secretion of ACTH: a case report. Gynecol Oncol 1997;65:526–9. DOI: 10.1006/gyno1997.4701. PMID: 9190988.16. Weberpals J., Djordjevic B., Khalifa M., Oza A. A rare case of ectopic adreno-corticotropic hormone syndrome in small cell carcinoma of the vagina: a case report. J Low Genit Tract Dis 2008;12:140–5. DOI: 10.1097/LGT.0b013e31815cda1e. PMID: 18369310.Weberpals J., Djordjevic B., Khalifa M., Oza A. A rare case of ectopic adreno-corticotropic hormone syndrome in small cell carcinoma of the vagina: a case report. J Low Genit Tract Dis 2008;12:140–5. DOI: 10.1097/LGT.0b013e31815cda1e. PMID: 18369310.17. Coleman N.M., Smith-Zagone MJ, Tanyi J et al. Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype. Am J Surg Pathol 2006;30:405–10. DOI: 10.1097/01.pas.0000194737.95421.9d. PMID: 16538063.Coleman N.M., Smith-Zagone MJ, Tanyi J et al. Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype. Am J Surg Pathol 2006;30:405–10. DOI: 10.1097/01.pas.0000194737.95421.9d. PMID: 16538063.18. Bhalodia J.N., Kapapura D.V., Parekh M.N. Primary small cell neuroendocrine carcinoma of vagina: a rare case report. Patholog Res Int 2011;2011:306921. DOI: 10.4061/2011/306921. PMID: 21977334.Bhalodia J.N., Kapapura D.V., Parekh M.N. Primary small cell neuroendocrine carcinoma of vagina: a rare case report. Patholog Res Int 2011;2011:306921. DOI: 10.4061/2011/306921. PMID: 21977334.19. Chafe W. Neuroepithelial small cell carcinoma of the vagina. Cancer 1989;64:1948–51. PMID: 2551478.Chafe W. Neuroepithelial small cell carcinoma of the vagina. Cancer 1989;64:1948–51. PMID: 2551478.20. Elsaleh H., Bydder S., Cassidy B., Thompson J. Small cell carcinoma of the vagina. Australas Radiol 2000;44:336–337. PMID: 10974733.Elsaleh H., Bydder S., Cassidy B., Thompson J. Small cell carcinoma of the vagina. Australas Radiol 2000;44:336–337. PMID: 10974733.21. Fukushima M., Twiggs L.B., Okagaki T. Mixed intestinal adenocarcinoma-argentaffin carcinoma of the vagina. Gynecol Oncol 1986;23:387–394.Fukushima M., Twiggs L.B., Okagaki T. Mixed intestinal adenocarcinoma-argentaffin carcinoma of the vagina. Gynecol Oncol 1986;23:387–394.22. Joseph R.E., Enghardt M.H., Doering D.L. et al. Small cell neuroendocrine carcinoma of the vagina. Cancer 1992;70:784–9. PMID: 1322783.Joseph R.E., Enghardt M.H., Doering D.L. et al. Small cell neuroendocrine carcinoma of the vagina. Cancer 1992;70:784–9. PMID: 1322783.23. Kaminski J.M., Anderson P.R., Han A.C. et al. Primary small cell carcinoma of the vagina. Gynecol Oncol 2003;88:451–455. PMID: 12648603.Kaminski J.M., Anderson P.R., Han A.C. et al. Primary small cell carcinoma of the vagina. Gynecol Oncol 2003;88:451–455. PMID: 12648603.24. Miliauskas J.R., Leong A.S. Small cell (neuroendocrine) carcinoma of the vagina. Histopathology 1992;21:371–4. PMID: 1328019.Miliauskas J.R., Leong A.S. Small cell (neuroendocrine) carcinoma of the vagina. Histopathology 1992;21:371–4. PMID: 1328019.25. Mirhashemi R., Kratz A., Weir M.M. et al. Vaginal small cell carcinoma mimicking a Bartholin’s gland abscess: a case report. Gynecol Oncol 1998;68:297–300. DOI: 10.1006/gyno.1998.4959. PMID: 9570984.Mirhashemi R., Kratz A., Weir M.M. et al. Vaginal small cell carcinoma mimicking a Bartholin’s gland abscess: a case report. Gynecol Oncol 1998;68:297–300. DOI: 10.1006/gyno.1998.4959. PMID: 9570984.26. Bing Z., Levine L., Lucci J.A. et al. Primary small cell neuroendocrine carcinoma of the vagina: a clinicopatho-logic study. Arch Pathol Lab Med 2004;128:857–62. DOI: 10.1043/1543–2165(2004)128<857:PSCNCO>2.0.CO;2. PMID: 15270619.Bing Z., Levine L., Lucci J.A. et al. Primary small cell neuroendocrine carcinoma of the vagina: a clinicopatho-logic study. Arch Pathol Lab Med 2004;128:857–62. DOI: 10.1043/1543–2165(2004)128<857:PSCNCO>2.0.CO;2. PMID: 15270619.27. Peters W.A., 3rd, Kumar N.B., Morley G.W. Carcinoma of the vagina. Factors influencing treatment outcome. Cancer 1985;55:892–97. PMID: 3967181.Peters W.A., 3rd, Kumar N.B., Morley G.W. Carcinoma of the vagina. Factors influencing treatment outcome. Cancer 1985;55:892–97. PMID: 3967181.28. Rusthoven J.J., Daya D. Small-cell carcinoma of the vagina. A clinicopatho-logic study. Arch Pathol Lab Med 1990;114:728–31. PMID: 1694657.Rusthoven J.J., Daya D. Small-cell carcinoma of the vagina. A clinicopatho-logic study. Arch Pathol Lab Med 1990;114:728–31. PMID: 1694657.29. Hopkins M.P., Kumar N.B., Lichter A.S. et al. Small cell carcinoma of the vagina with neuroendocrine features. A report of three cases. J Reprod Med 1989;34:486–91. PMID: 2549239.Hopkins M.P., Kumar N.B., Lichter A.S. et al. Small cell carcinoma of the vagina with neuroendocrine features. A report of three cases. J Reprod Med 1989;34:486–91. PMID: 2549239.