Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press54810.17650/1994-4098-2017-13-3-17-27MAMMOLOGY. REVIEWSМАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИDIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGISTДИАГНОСТИКА И ПРОФИЛАКТИКА КАРДИОТОКСИЧНОСТИ У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ С ПОЗИЦИЙ ОНКОЛОГА И КАРДИОЛОГАSemiglazovaT. Yu.СемиглазоваТ. Ю.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758; 41 Kirochnaya St., Saint Petersburg, 191015

Татьяна Юрьевна Семиглазова.

197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015, Санкт-Петербург, ул. Кирочная, 41

tsemiglazova@mail.ruTeletaevaG. M.ТелетаеваГ. М.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

KozyavinN. A.КозявинН. А.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

ZagatinaA. V.ЗагатинаА. В.
Russian Federation

Space 8H, lit. A, 23/25 Degtyarnaya St., Saint Petersburg, 191144

191144, Санкт-Петербург, ул. Дегтярная, 23/25 лит. А, помещение 8Н

N.N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииNorth-Western State Medical University named after I. I. Mechnikov, Ministry of Health of RussiaФГБОУ ВО «Cеверо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииMedica ClinicООО «Клиника “Медика”»0609201713317270609201706092017https://ojrs.abvpress.ru/ojrs/article/view/548

Knowledge of anthracycline antibiotics’ (AAs) pathogenesis and main risk factors allowed to develop various methods of prevention and early detection of cardiotoxicity as well as to create several guidelines on decreasing the risk of its development. Traditional AAs are a crucial option in treatment of metastatic breast cancer including their repeated prescription. However, their application is significantly limited by various manifestations of toxicity, especially cumulative cardiotoxicity. The most promising is use of pegylated liposomal pharmaceutical formulations of AAs. Among these formulations, pegylated liposomal doxorubicin almost fully lacks anthracycline cardiotoxicity because due to its unique formulation it accumulates almost exclusively in tumor tissue.

Знание патогенеза и основных факторов риска кардиотоксичности антрациклиновыми антибиотиками (АА) позволило разработать различные методики, направленные на предупреждение и раннее выявление кардиотоксичности, а также создать ряд рекомендаций по уменьшению риска ее развития. Традиционные АА являются важнейшей опцией лечения метастатического рака молочной железы, включая повторное их назначение. Однако возможности их применения значительно ограничены из-за различных проявлений токсичности, особенно кумулятивной кардиотоксичности. Наиболее перспективным является применение пегилированных липосомных лекарственных форм АА. И в их ряду пегилированный липосомальный доксорубицин благодаря своей уникальной формуле практически не обладает антрациклиновой кардиотоксичностью, так как накапливается преимущественно в опухолевой ткани.

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