Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press55910.17650/1994-4098-2017-13-4-24-28MAMMOLOGY. ORIGINAL REPORTSМАММОЛОГИЯ. ОРИГИНАЛЬНЫЕ СТАТЬИOWN EXPERIENCE OF LASER THERAPY FOR THE PREVENTION AND TREATMENT OF EARLY AND LATE RADIATION-INDUCED SKIN INJURIES IN PATIENTS WITH BREAST CANCER AFTER SIMULTANEOUS RECONSTRUCTIVE PLASTIC SURGERYСОБСТВЕННЫЙ ОПЫТ ПРИМЕНЕНИЯ ЛАЗЕРНОЙ ТЕРАПИИ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ РАННИХ И ПОЗДНИХ ЛУЧЕВЫХ ПОВРЕЖДЕНИЙ КОЖИ У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ ПОСЛЕ ОДНОМОМЕНТНОЙ РЕКОНСТРУКТИВНО-ПЛАСТИЧЕСКОЙ ОПЕРАЦИИTkachevS. I.ТкачевС. И.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

NazarenkoA. V.НазаренкоА. В.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

TimoshkinaE. V.ТимошкинаЕ. В.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

Екатерина Валерьевна Тимошкина.

115478 Москва, Каширское шоссе, 23

doctoretim@gmail.comTrofimovaO. P.ТрофимоваО. П.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

GlebovskayaV. V.ГлебовскаяВ. В.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

IvanovS. M.ИвановС. М.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

BorisovaT. N.БорисоваТ. Н.
Russian Federation

23 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 23

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России2112201713424282212201722122017https://ojrs.abvpress.ru/ojrs/article/view/559

Low-energy laser radiation has a good anti-inflammatory and stimulating effect on the damaged tissues; therefore, it can be used for the prevention and treatment of both early and late radiation-induced skin injuries in patients receiving radiotherapy. So far, the effect of low-energy laser radiation in the prevention of radiation-induced skin damage remains poorly understood. This article presents a brief overview of the results obtained in the latest foreign studies as well as own experience of laser therapy for the prevention and treatment of both early and late radiation-induced skin injuries in patients with breast cancer after simultaneous reconstructive plastic surgery.

Низкоэнергетическое лазерное излучение обладает противовоспалительным и стимулирующим действием на поврежденные ткани и потому может быть использовано для профилактики и лечения как ранних, так и поздних лучевых повреждений кожи у пациентов, получающих лучевую терапию. На данный момент использование низкоэнергетического лазерного излучения в профилактике лучевых повреждений кожи по-прежнему остается малоизученным. В настоящей работе представлен краткий обзор результатов современных зарубежных исследований и собственного опыта применения лазерной терапии для профилактики и лечения ранних и поздних лучевых повреждений кожи у больных раком молочной железы после одномоментной реконструктивно-пластической операции.

low-energy laser radiationradiation-induced skin injuriesbreast cancerreconstructive plastic surgeryнизкоэнергетическое лазерное излучениелучевые повреждения кожирак молочной железыреконструктивно-пластическая операция1. Thiel H. Low power laser therapy – an introduction and a review of some biological effects. J Can Chiropr Assoc 1986;30(3):133–8.Thiel H. Low power laser therapy – an introduction and a review of some biological effects. J Can Chiropr Assoc 1986;30(3):133–8.2. Hawkins D., Abrahamse H. Biological effects of helium-neon laser irradiation on normal and wounded human skin fibroblasts. Photomed Laser Surg 2005;23(3):251–9. DOI: 10.1089/pho.2005.23.251.Hawkins D., Abrahamse H. Biological effects of helium-neon laser irradiation on normal and wounded human skin fibroblasts. Photomed Laser Surg 2005;23(3):251–9. DOI: 10.1089/pho.2005.23.251.3. Bray F.N., Simmons B.J., Wolfson A.H., Nouri K. Acute and chronic cutaneous reactions to ionizing radiation therapy. Dermatol Ther (Heidelb) 2016;6(2):185–206. DOI: 10.1007/s13555-016-0120-y.Bray F.N., Simmons B.J., Wolfson A.H., Nouri K. Acute and chronic cutaneous reactions to ionizing radiation therapy. Dermatol Ther (Heidelb) 2016;6(2):185–206. DOI: 10.1007/s13555-016-0120-y.4. Singh M., Alavi A., Wong R. et al. Radiodermatitis: a review of our current understanding. Am J Clin Dermatol 2016;17(3):277–92. DOI: 10.1007/s40257-016-0186-4.Singh M., Alavi A., Wong R. et al. Radiodermatitis: a review of our current understanding. Am J Clin Dermatol 2016;17(3):277–92. DOI: 10.1007/s40257-016-0186-4.5. Nevens D., Duprez F., Daisne J.F. et al. Radiotherapy induced dermatitis is a strong predictor for late fibrosis in head and neck cancer. The development of a predictive model for late fibrosis. Radiother Oncol 2017;122(2):212–6. DOI: 10.1016/j.radonc.2016.08.013.Nevens D., Duprez F., Daisne J.F. et al. Radiotherapy induced dermatitis is a strong predictor for late fibrosis in head and neck cancer. The development of a predictive model for late fibrosis. Radiother Oncol 2017;122(2):212–6. DOI: 10.1016/j.radonc.2016.08.013.6. Simonen P., Hamilton C., Ferguson S. et al. Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans? Radiother Oncol 1998;46(1):73–82. PMID: 9488130.Simonen P., Hamilton C., Ferguson S. et al. Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans? Radiother Oncol 1998;46(1):73–82. PMID: 9488130.7. O’Sullivan B., Levin W. Late radiation-related fibrosis: pathogenesis, manifestations and current management. Semin Radiat Oncol 2003;13(3):274–89. DOI: 10.1016/S1053-4296(03)00037-7.O’Sullivan B., Levin W. Late radiation-related fibrosis: pathogenesis, manifestations and current management. Semin Radiat Oncol 2003;13(3):274–89. DOI: 10.1016/S1053-4296(03)00037-7.8. Silva C.R, Cabral F.V., de Camargo C.F. et al. Exploring the effects of low-level laser therapy on fibroblasts and tumor cells following gamma radiation exposure. J Biophotonics 2016;9(11–12):1157–66. DOI: 10.1002/jbio.201600107.Silva C.R, Cabral F.V., de Camargo C.F. et al. Exploring the effects of low-level laser therapy on fibroblasts and tumor cells following gamma radiation exposure. J Biophotonics 2016;9(11–12):1157–66. DOI: 10.1002/jbio.201600107.9. Yu P. Breast reconstruction at the MD Anderson Cancer Center. Gland Surg 2016;5(4):416–21. DOI: 10.21037/gs.2016.05.03.Yu P. Breast reconstruction at the MD Anderson Cancer Center. Gland Surg 2016;5(4):416–21. DOI: 10.21037/gs.2016.05.03.10. El-Sabawi B., Carey J.N., Hagopian T.M. et al. Radiation and breast reconstruction: algorithmic approach and evidence-based outcomes. J Surg Oncol 2016;113(8):906–12. DOI: 10.1002/jso.24143.El-Sabawi B., Carey J.N., Hagopian T.M. et al. Radiation and breast reconstruction: algorithmic approach and evidence-based outcomes. J Surg Oncol 2016;113(8):906–12. DOI: 10.1002/jso.24143.11. Storz M.A., Gronwald B., Gottschling S. et al. Photobiomodulation therapy in breast cancer-related lymphedema: a randomized placebo-controlled trial. Photodermatol Photoimmunol Photomed 2017;33(1):32–40. DOI: 10.1111/phpp.12284.Storz M.A., Gronwald B., Gottschling S. et al. Photobiomodulation therapy in breast cancer-related lymphedema: a randomized placebo-controlled trial. Photodermatol Photoimmunol Photomed 2017;33(1):32–40. DOI: 10.1111/phpp.12284.12. Smoot B., Chiavola-Larson L., Lee J. et al. Effect of low-level laser therapy on pain and swelling in women with breast cancer-related lymphedema: a systematic review and meta-analysis. J Cancer Surviv 2015;9(2):287–304. DOI: 10.1007/s11764-014-0411-1.Smoot B., Chiavola-Larson L., Lee J. et al. Effect of low-level laser therapy on pain and swelling in women with breast cancer-related lymphedema: a systematic review and meta-analysis. J Cancer Surviv 2015;9(2):287–304. DOI: 10.1007/s11764-014-0411-1.13. Common Terminology Criteria for Adverse Events (CTCAE) v4.03. Available at: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf.Common Terminology Criteria for Adverse Events (CTCAE) v4.03. Available at: https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf.14. Rossi A.M., Nehal K.S., Lee E.H. Radiation-induced breast telangiectasias treated with the pulsed dye laser. J Clin Aesthet Dermatol 2014;7(12):34–7. PMID: 25584136.Rossi A.M., Nehal K.S., Lee E.H. Radiation-induced breast telangiectasias treated with the pulsed dye laser. J Clin Aesthet Dermatol 2014;7(12):34–7. PMID: 25584136.15. Langian S.W., Joannides T. Pulsed dye laser treatment of telangiectasia after radiotherapy for carcinoma of the breast. Br J Dermatol 2003;148(1):77–9. PMID: 12534598.Langian S.W., Joannides T. Pulsed dye laser treatment of telangiectasia after radiotherapy for carcinoma of the breast. Br J Dermatol 2003;148(1):77–9. PMID: 12534598.16. Censabella S., Claes S., Robijns J. et al. Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS® laser therapy in breast cancer patients. Support Care Cancer 2016;24(9):3925–33. DOI: 10.1007/s00520-016-3232-0.Censabella S., Claes S., Robijns J. et al. Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS® laser therapy in breast cancer patients. Support Care Cancer 2016;24(9):3925–33. DOI: 10.1007/s00520-016-3232-0.17. Costa M.M., Silva S.B., Quinto A.L. et al. Phototherapy 660 nm for the prevention of radiodermatitis in breast cancer patients receiving radiation therapy: study protocol for a randomized controlled trial. Trials 2014;15:330. DOI: 10.1186/1745-6215-15-330.Costa M.M., Silva S.B., Quinto A.L. et al. Phototherapy 660 nm for the prevention of radiodermatitis in breast cancer patients receiving radiation therapy: study protocol for a randomized controlled trial. Trials 2014;15:330. DOI: 10.1186/1745-6215-15-330.