Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press56110.17650/1994-4098-2017-13-4-34-43MAMMOLOGY. REVIEWSМАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИCYCLIN-DEPENDENT KINASE INHIBITOR, PALBOCICLIB – A NEW DRUG FOR THE TREATMENT OF METASTATIC BREAST CANCERИНГИБИТОР ЦИКЛИНЗАВИСИМЫХ КИНАЗ ПАЛБОЦИКЛИБ – НОВЫЙ ПРЕПАРАТ ДЛЯ ЛЕЧЕНИЯ МЕТАСТАТИЧЕСКОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫImyanitovE. N.ИмянитовЕ. Н.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015; 2 Litovskaya St., Saint Petersburg 194100

Евгений Наумович Имянитов.

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015 Санкт-Петербург, ул. Кирочная, 41; 194100 Санкт-Петербург, ул. Литовская, 2

evgeny@imyanitov.spb.ruSemiglazovaT. Yu.СемиглазоваТ. Ю.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

Татьяна Юрьевна Семиглазова.

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015 Санкт-Петербург, ул. Кирочная, 41

tsemiglazova@mail.ruN.N. Petrov National Medical Research Center of Onclology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииSaint Petersburg State Pediatric Medical University, Ministry of Health of RussiaФГБОУ ВО «Cеверо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииГБОУ ВПО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииN.N. Petrov National Medical Research Center of Onclology, Ministry of Health of RussiaI.I. Mechnikov North-Western State Medical University Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииФГБОУ ВО «Cеверо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России2112201713434432212201722122017https://ojrs.abvpress.ru/ojrs/article/view/561

The sequential use of several lines of endocrine therapy is considered the standard for the treatment of metastatic breast cancer, expressing estrogen or progesterone receptors. PALOMA-1, -2 and -3 studies showed that the combination of the inhibitor of CDK4/6, palbociclib, with endocrine therapy significantly increases the time to progression compared to the use of monotherapy with antagonists of the estrogen signaling cascade.

Последовательное применение нескольких линий гормональной терапии считается стандартом лечения метастатического рака молочной железы, экспрессирующего рецепторы эстрогенов или прогестерона. Исследования PALOMA-1, -2 и -3 показали, что сочетание ингибитора CDK4/6 палбоциклиба с гормональной терапией значительно увеличивает время до прогрессирования по сравнению с монотерапией антагонистами сигнального каскада эстрогенов.

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