Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press6010.17650/1994-4098-2013-0-3-4-67-71GYNECOLOGY. DIAGNOSISГИНЕКОЛОГИЯ. ДИАГНОСТИКАTumor markers in the diagnosis of cancer of the corpus uteri (a review of literature)Опухолевые маркеры в диагностике рака тела матки (обзор литературы)OlkinD. B.ОлькинД. Б.
Russian Federation
olkindmitry@yandex.ruBokinaL. I.БокинаЛ. И.
Russian Federation
MustafinaE. A.МустафинаЕ. А.
Russian Federation
BarinovV. V.БариновВ. В.
Russian Federation
BokinI. I.БокинИ. И.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва220920133-4677122072014220720142013https://ojrs.abvpress.ru/ojrs/article/view/60

Towards the end of the past century, cancer of the corpus uteri achieved the status of leading gynecologic cancer not only in developed countries, but also in Third World countries. The leading determinants of prognosis and treatment policy are tumor extent and grade at diagnosis. It is important to search for the informative and significant indicators of biological tumor activity, which are determined by pre- and postoperative mini-invasive laboratory studies, the combination of which could additionally judge the extent and grade of a tumor. At present, there are no significant tumor markers for the screening for and evaluation of progressive cancer of the corpus uteri, which would have a high specificity and sensitivity although their search is constantly underway worldwide.

Рак тела матки к концу прошлого столетия приобрел статус ведущей онкогинекологической патологии не только в экономиче- ски развитых странах, но и в странах третьего мира. Ведущими факторами, определяющими прогноз заболевания и выбор так- тики лечения, являются распространенность опухоли и степень ее дифференцировки к моменту диагностики. Актуальным яв- ляется поиск информативных и значимых показателей биологической активности опухоли, определяемых малоинвазивными лабораторными методами в до- и послеоперационном периодах, комбинация которых позволила бы дополнительно судить о рас- пространенности и степени дифференцировки опухоли. В настоящее время не существует значимых опухолевых маркеров для скрининга и оценки прогрессирования рака тела матки, которые обладали бы высокой специфичностью и чувствительностью, хотя постоянно ведется их поиск.

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