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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">604</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2018-14-3-25-39</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>MAMMOLOGY. REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>МАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Main risk factors for breast cancer and proposals for its prevention</article-title><trans-title-group xml:lang="ru"><trans-title>Основные риски развития рака молочной железы и предложения по его профилактике</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Portnoy</surname><given-names>S. M.</given-names></name><name xml:lang="ru"><surname>Портной</surname><given-names>С. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Build. 7, 5 Lefortovskiy Val, Moscow 111116 </p></bio><bio xml:lang="ru"><p>111116 Москва, Лефортовский вал, 5, стр. 7 </p></bio><email>sportnoj@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Frau Clinic, LLC</institution></aff><aff><institution xml:lang="ru">ООО «Фрау Клиник»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-10-16" publication-format="electronic"><day>16</day><month>10</month><year>2018</year></pub-date><volume>14</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>25</fpage><lpage>39</lpage><history><date date-type="received" iso-8601-date="2018-10-15"><day>15</day><month>10</month><year>2018</year></date><date date-type="accepted" iso-8601-date="2018-10-15"><day>15</day><month>10</month><year>2018</year></date></history><permissions><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/604">https://ojrs.abvpress.ru/ojrs/article/view/604</self-uri><abstract xml:lang="en"><p>This systematic literature review aims to explore currently accepted risk factors for breast cancer, including reproductive status, overweight, radiation, breast radiological density, benign lesions, family history of breast cancer and mutations in breast cancer predisposition genes. The review also covers measures to prevent breast cancer.</p></abstract><trans-abstract xml:lang="ru"><p>Настоящий обзор литературы посвящен современному представлению о рисках развития рака молочной железы (РМЖ), к которым относятся особенности репродуктивной жизни женщины, избыточная масса тела, радиация, рентгенологическая плотность ткани молочной железы, наличие доброкачественных поражений, отягощенная наследственность по РМЖ, мутации генов предрасположенности к развитию РМЖ. Рассмотрены также меры профилактики развития РМЖ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>risk of breast cancer</kwd><kwd>BRCA1</kwd><kwd>BRCA2</kwd><kwd>ATM</kwd><kwd>BLM</kwd><kwd>BRIP1</kwd><kwd>CDH1</kwd><kwd>CHEK2</kwd><kwd>LKB1</kwd><kwd>NBS1</kwd><kwd>MLH1</kwd><kwd>PALB2</kwd><kwd>PTEN</kwd><kwd>RECQL</kwd><kwd>TP53</kwd><kwd>preventive mastectomy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>риск развития рака молочной железы, BRCA1, BRCA2, ATM, BLM, BRIP1, CDH1, CHEK2, LKB1, NBS1, MLH1, PALB2, PTEN, RECQL, TP53, профилактическая мастэктомия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Злокачественные новообразования в России в 2016 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦР» Минздрава России, 2017. 250 с. 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