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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Tumors of female reproductive system</journal-id><journal-title-group><journal-title xml:lang="en">Tumors of female reproductive system</journal-title><trans-title-group xml:lang="ru"><trans-title>Опухоли женской репродуктивной системы</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-4098</issn><issn publication-format="electronic">1999-8627</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">622</article-id><article-id pub-id-type="doi">10.17650/1994-4098-2018-14-4-72-79</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GYNECOLOGY. REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Lymphatic cysts after gynecological cancer surgery: risk factors, diagnosis and treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Лимфатические кисты после хирургического лечения онкогинекологических больных: факторы риска, диагностика и лечение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rogovskaya</surname><given-names>Т. Т.</given-names></name><name xml:lang="ru"><surname>Роговская</surname><given-names>Т. Т.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758</italic></p></bio><bio xml:lang="ru"><p><bold>Татьяна Томовна Роговская</bold></p><p><italic>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68</italic><italic/></p><p><bold/></p></bio><email>t.rogovskaya@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Berlev</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Берлев</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><italic>68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758, <italic>41 Kirochnaya St., Saint Petersburg 191015</italic></italic></p></bio><bio xml:lang="ru"><p><italic>197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68, </italic></p><p><italic>191015 Санкт-Петербург, ул. Кирочная, 41 </italic><italic/></p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.I. Mechnikov North-Western State Medical University Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-12-21" publication-format="electronic"><day>21</day><month>12</month><year>2018</year></pub-date><volume>14</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>72</fpage><lpage>79</lpage><history><date date-type="received" iso-8601-date="2019-02-21"><day>21</day><month>02</month><year>2019</year></date><date date-type="accepted" iso-8601-date="2019-02-21"><day>21</day><month>02</month><year>2019</year></date></history><permissions><copyright-year>2018</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ojrs.abvpress.ru/ojrs/article/view/622">https://ojrs.abvpress.ru/ojrs/article/view/622</self-uri><abstract xml:lang="en"><p>Lymphatic cysts, also known as lymphocele, are one of the most common complications after pelvic and paraaortic lymph node dissection in patients with gynecological cancers. Despite the high incidence of this complication, no specific guidelines on the diagnosis and treatment of lymphocele have been developed so far. This article analyzes the incidence of lymphatic cysts, risk factors, and currently available options for their diagnosis and treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Лимфатические кисты, или лимфоцеле – одно из самых частых осложнений тазовой и парааортальной лимфодиссекции у онкогинекологических больных. Несмотря на широкую встречаемость данного осложнения, в современной литературе не определены оптимальные рекомендации по лечению и диагностике лимфоцеле. В статье приводится обсуждение и анализ данных литературы о частоте возникновения лимфатических кист, факторах риска их формирования и существующих методах диагностики и лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>lymphatic cysts</kwd><kwd>lymphocele</kwd><kwd>pelvic lymphadenectomy</kwd><kwd>paraaortic lymphadenectomy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лимфатические кисты</kwd><kwd>лимфоцеле</kwd><kwd>тазовая лимфаденэктомия</kwd><kwd>парааортальная лимфаденэктомия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ballester M., Bendifallah S., Daraï E. European guidelines (ESMO-ESGOESTRO consensus conference) for the management of endometrial cancer. Bull Cancer 2017;104(12):1032–8. PMID: 29173977. DOI: 10.1016/j.bulcan.2017.10.006.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Cibula D., Pötter R., Planchamp F. et al. The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology guidelines for the management of patients with cervical cancer. Radiother Oncol 2018;127(3):404–16. PMID: 29728273. DOI: 10.1016/j.radonc.2018.03.003.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Weinberger V., Cibula D., Zikan M. Lymphocele: prevalence and management in gynecological malignancies. Expert Rev Anticancer Ther 2014;14(3):307–17. PMID: 24483760. DOI: 10.1586/14737140.2014.866043.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Ghezzi F., Uccella S., Cromi A. et al. Lymphoceles, lymphorrhea, and lymphedema after laparoscopic and open endometrial cancer staging. Ann Surg Oncol 2012;19(1):259–67. PMID: 21695563. DOI: 10.1245/s10434-011-1854-5.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Ilancheran A., Monaghan J.M. Pelvic lymphocyst – a 10-year experience. Gynecol Oncol 1988;29(3):333–6. PMID: 3345953.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Mori N. Clinical and experimental studies on the so-called lymphocyst which develops after radical hysterectomy in cancer of the uterine cervix. J Jpn Obstet Gynecol Soc 1955;2(2):178–203. PMID: 13286539.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Tam K.F., Lam K.W., Chan K.K., Ngan H.Y. Natural history of pelvic lymphocysts as observed by ultrasonography after bilateral pelvic lymphadenectomy. Ultrasound Obstet Gynecol 2008;32(1):87–90. PMID: 18548478. DOI: 10.1002/uog.5345.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>McMahon C.J., Rofsky N.M., Pedrosa I. Lymphatic metastases from pelvic tumors: anatomic classification, characterization, and staging. Radiology 2010;254:31–46. PMID: 20032141. DOI: 10.1148/radiol.2541090361.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lengele B., Scalliet P. Anatomical bases for the radiological delineation of lymph node areas. Part III: Pelvis and lower limbs. Radiother Oncol 2009;92(1):22–33. PMID: 19095323. DOI: 10.1016/j.radonc.2008.11.007.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Hedgire S.S., Pargaonkar V.K., Elmi A. et al. Pelvic nodal imaging. Radiol Clin North Am 2012;50(6):1111–25. PMID: 23122041. DOI: 10.1016/j.rcl.2012.08.002.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Tinelli A., Mynbaev O.A., Tsin D.A. et al. Lymphocele prevention after pelvic laparoscopic lymphadenectomy by a collagen patch coated with human coagulation factors: a matched case-control study. Int J Gynecol Cancer 2013;23(5):956–63. PMID: 23574881. DOI: 10.1097/IGC.0b013e31828eeea4.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Yin H., Gui T. Comparative analyses of postoperative complications and prognosis of different surgical procedures in stage II endometrial carcinoma treatment. Onco Targets Ther 2016;9:781–6. PMID: 26937200. DOI: 10.2147/OTT.S95806.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kim Y.H., Shin H.J., Ju W., Kim S.C. Prevention of lymphocele by using gelatinthrombin matrix as a tissue sealant after pelvic lymphadenectomy in patients with gynecologic cancers: a prospective randomized controlled study. J Gynecol Oncol 2017;28(3):e37. PMID: 28382800. DOI: 10.3802/jgo.2017.28.e37.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Hiramatsu K., Kobayashi E., Ueda Y. et al. Optimal timing for drainage of infected lymphocysts after lymphadenectomy for gynecologic cancer. Int J Gynecol Cancer 2015;25(2):337–41. PMID: 25594145. DOI: 10.1097/IGC.0000000000000353.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Kondo E., Tabata T., Shiozaki T. et al. Large or persistent lymphocyst increases the risk of lymphedema, lymphangitis, and deep vein thrombosis after retroperitoneal lymphadenectomy for gynecologic malignancy. Arch Gynecol Obstet 2013;288(3):587–93. PMID: 23455541. DOI: 10.1007/s00404-013-2769-0.</mixed-citation></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Oleynik V.V. Lymph cysts after extensive surgery for cervical and uterine cancer. Summary of thesis. … of candidate of medical sciences. Saint Petersburg, 1996. 25 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Олейник В.В. Лимфатические кисты после расширенных операций по поводу рака шейки матки и тела матки. Автореф. дис. … канд. мед. наук. СанктПетербург, 1996. 25 с.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><mixed-citation>Kim H.Y., Kim J.W., Kim S.H. et al. An analysis of the risk factors and management of lymphocele after pelvic lymphadenectomy in patients with gynecologic malignancies. Cancer Res Treat 2004;36(6):377–83. PMID: 20368832. DOI: 10.4143/crt.2004.36.6.377.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Charoenkwan K., Kietpeerakool C. Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in women with gynaecological malignancies. Cochrane Database Syst Rev 2017;6:CD007387. DOI: 10.1002/14651858.CD007387.pub4.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Achouri A., Huchon C., Bats A.S. et al. Complications of lymphadenectomy for gynecologic cancer. Eur J Surg Oncol 2013;39(1):81–6. PMID: 23117018. DOI: 10.1016/j.ejso.2012.10.011.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Zikan M., Daniela F., Pinkavova I. et al. A prospective study examining the incidence of asymptomatic and symptomatic lymphoceles following lymphadenectomy in patients with gynecological cancer. Gynecol Oncol 2015;137(2):291–8. PMID: 25720294. DOI: 10.1016/j.ygyno.2015.02.016.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Symmond R. Morbidity and complications of radical hysterectomy with pelvic lymph node dissection. Am J Obstet Gynecol 1966;94(5):663–78. PMID: 5906590.</mixed-citation></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Stepanov S.O., Novikova E.G., Skreptsova N.S. Ultrasound diagnosis and treatment strategy in patients with lymphoceles after gynecological cancer surgery. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2009;2(32):25–30. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Степанов С.О., Новикова Е.Г., Скрепцова Н.С. Ультразвуковая диагностика и тактика при лимфоцеле после онкогинекологических операций. Сибирский онкологический журнал 2009;2(32):25–30.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><mixed-citation>De Blasis I., Vinci V., Sergi M.E. et al. Early and late onset complications of gynaecologic surgery: a multimodality imaging approach. Facts Views Vis Obgyn 2017;9(1):5–14. PMID: 28721179.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Vansonnenberg E., Wittich G.R., Casola G. et al. Lymphoceles: imaging characteristics and percutaneous management. Radiology 1986;161(3):593–6. PMID: 3538133. DOI: 10.1148/radiology.161.3.3538133.</mixed-citation></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">Frantsev D.Yu. Postoperative pelvic lymphatic cysts. Klinicheskaya i eksperimentalnaya khirurgiya. Zhurnal im. akad. B.V. Petrovskogo = B.V. Petrovskiy Journal of Clinical and Experimental Surgery 2015;(4):113–20. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Францев Д.Ю. Послеоперационные лимфатические кисты таза: аналитический обзор. Клиническая и экспериментальная хирургия. Журнал им. акад. Б.В. Петровского 2015;(4):113–20.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><mixed-citation>Petru E., Tamussino K., Lahousen M. et al. Pelvic and paraaortic lymphocysts after radical surgery because of cervical and ovarian cancer. Am J Obstet Gynecol 1989;161(4):937–41. PMID: 2801842.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Sahbaz A., Gungorduk K., Gulseren V. et al. What are the risk factors for lymphocyst formation apart from lymphnode dissection and lymphnode count in gynecologic malignancy? Geburtsh Frauenheilk 2016;76(4):403–7. DOI: 10.1055/s-0041-110804.</mixed-citation></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">Kedrova A.G., Shablovskiy O.R., Levakov S.A. et al. Low-molecular-weight heparin in combination therapy for tumors of the female reproductive system. Opukholi zhenskoy reproduktivnoy sistemy = Tumors of Female Reproductive System 2017;13(2):47–55. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Кедрова А.Г., Шабловский О.Р., Леваков С.А. и др. Возможности применения низкомолекулярных гепаринов в комплексном лечении женщин с опухолями женской репродуктивной системы. Опухоли женской репродуктивной системы 2017;13(2):47–55.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><mixed-citation>Baraem Y., Ahn H., Kim M. et al. Nomogram predicting risk of lymphocele in gynecologic cancer patients undergoing pelvic lymph node dissection. Obstet Gynecol Sci 2017;60(5):440–8. PMID: 28989920. DOI: 10.5468/ogs.2017.60.5.440.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Van Nagell J., Schweitz D. Surgical adjuncts in radical hysterectomy and pelvic lymphadenectomy. Surg Gynecol Obstet 1976;143(5):735–7. PMID: 790612.</mixed-citation></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">Bokhman Ya.V. Gynecological oncology: a guideline. Leningrad: Meditsina, 1989. 464 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Бохман Я.В. Руководство по онкогинекологии. Л.: Медицина, 1989. 464 c.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><mixed-citation>Benedetti-Panici P., Maneschi F., Cutillo G. et al. A randomized study comparing retroperitoneal drainage with no drainage after lymphadenectomy in gynecologic malignancies. Gynecol Oncol 1997;65(3):478–82. PMID: 9190979.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Franchi M., Trimbos J., Zanaboni F. et al. Randomised trial of drains versus no drains following radical hysterectomy and pelvic lymph node dissection: a European Organisation for Research and Treatment of Cancer-Gynaecological Cancer Group (EORTC-GCG) study in 234 patients. Eur J Cancer 2007;43(8):1265–8. PMID: 17466514. DOI: 10.1016/j.ejca.2007.03.011.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Suzuki M., Ohwada M., Sato I. Pelvic lymphocysts following retroperitoneal lymphadenectomy: retroperitoneal partial “no-closure” for ovarian and endometrial cancers. J Surg Oncol 1998;68(3):149–52.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Thome Saint Paul M., Bremond A., Rochet Y. Absence of peritonization after pelvic cancer surgery. Results in 157 cases. J Gynecol Obstet Biol Reprod 1991;20(7):957–60.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Franchi M., Ghezzi F., Zanaboni F. et al. Nonclosure of peritoneum at radical abdominal hysterectomy and pelvic node dissection: a randomized study. Obstet Gynecol 1997;90(4 Pt 1):622–7. PMID: 9380327.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Radosa M.P., Diebolder H., Camara O. et al. Laparoscopic lymphocele fenestration in gynaecological cancer patients after retroperitoneal lymph node dissection as a first-line treatment option. BJOG 2013;120(5):628–36. PMID: 23320834. DOI: 10.1111/1471-0528.12103.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Karcaaltincaba M., Akhan О. Radiologic imaging and percutaneous treatment of pelvic lymphocele. Eur J Radiol 2005;55(3):340–54. PMID: 15885959. DOI: 10.1016/j.ejrad.2005.03.007.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Kim J.K., Jeong Y.Y., Kim Y.H. et al. Postoperative pelvic lymphocele: treatment with simple percutaneous catheter drainage. Radiology 1999;212(2):390–4.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Conte M., Panici P.B., Guariglia L. et al. Pelvic lymphocele following radical para-aortic and pelvic lymphadenectomy for cervical carcinoma: incidence rate and percutaneous management. Obstet Gynecol 1990;76(2):268–71. PMID: 2196500.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Teruel J.L., Escobar E.M., Quereda C. et al. A simple and safe method for management of lymphocele after renal transplantation. J Urol 1983;130(6):1058–9. PMID: 6358528.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Alago W.Jr., Deodhar A., Michell H. et al. Management of postoperative lymphoceles after lymphadenectomy: percutaneous catheter drainage with and without povidone-iodine sclerotherapy. Cardiovasc Intervent Radiol 2013;36(2):466–71. PMID: 22484702. DOI: 10.1007/s00270-012-0375-3.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Rivera M., Marcen R., Burgos J. et al. Treatment of posttransplant lymphocele with povidone-iodine sclerosis: long-term follow-up. Nephron 1996;74(2):324–7. PMID: 8893149. DOI: 10.1159/000189329.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Zuckerman D.A., Yeager T.D. Percutaneous ethanol sclerotherapy of postoperative lymphoceles. Am J Roentgenol 1997;169(2):433–7. PMID: 9242748. DOI: 10.2214/ajr.169.2.9242748.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Elsandabesee D., Sharma B., Preston J. et al. Sclerotherapy with bleomycin for recurrent massive inguinal lymphoceles following partial vulvectomy and bilateral lymphadenectomy – case report and literature review. Gynecol Oncol 2004;92(2):716–8. PMID: 14766274. DOI: 10.1016/j.ygyno.2003.11.007.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Fernandes A.S., Costa A., Mota R. et al. Bleomycin sclerotherapy for severe symptomatic and persistent pelvic lymphocele. Case Rep Obstet Gynecol 2014;2014:624803. DOI: 10.1155/2014/624803.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Kurata H., Aoki Y., Tanaka K. Simple one-step catheter placement for the treatment of infected lymphocele. Eur J Obstet Gynecol Reprod Biol 2003;106(1):69–71. PMID: 12475585.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Kawamura I., Hirashima Y., Tsukahara M. et al. Microbiology of pelvic lymphocyst infection after lymphadenectomy for malignant gynecologic tumors. Surg Infect (Larchmt) 2015;16(3):244–6. PMID: 25651071. DOI: 10.1089/sur.2014.021.</mixed-citation></ref></ref-list></back></article>
