Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press66210.17650/1994-4098-2019-15-3-44-53GYNECOLOGY. REVIEWSГИНЕКОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИMelanoma of the lower female genital tract (vulva, vagina, and cervix): literature review and own casesМеланома нижнего женского полового тракта (вульвы, влагалища и шейки матки): обзор литературы и собственные наблюденияSafronovaK. V.СафроноваК. В.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

Кристина Витальевна Сафронова

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015Санкт-Петербург, ул. Кирочная, 41

kristina-skalli@yandex.ruArtemyevaA. S.АртемьеваА. С.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

SidorukA. A.СидорукА. А.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

ChuglovaD. A.ЧугловаД. А.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

KhidishyanK. E.ХидишянК. Е.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

MikayaN. A.МикаяН. А.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

BerlevI. V.БерлевИ. В.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015Санкт-Петербург, ул. Кирочная, 41

UrmancheevaA. F.УрманчееваА. Ф.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015Санкт-Петербург, ул. Кирочная, 41

UlrikhE. A.УльрихЕ. А.
Russian Federation

68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68; 191015Санкт-Петербург, ул. Кирочная, 41

N.N. Petrov National Medical Research Center of Onclology, Ministry of Health of RussiaФГБУ«Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaФГБОУВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России1411201915344531411201914112019https://ojrs.abvpress.ru/ojrs/article/view/662

The article covers various aspects of clinical manifestations, diagnosis, and treatment of vulvar, vaginal, and cervical melanomas.

В статье освещены особенности диагностики, клиническая картина и различные подходы к лечению меланом вульвы, влагалища и шейки матки.

melanomavulvavaginacervixмеланомавульвавлагалищешейка матки1. Tacastacas J.D., Bray J., Cohen Y.K. et al. Update on primary mucosal melanoma. J Am Acad Dermatol 2014;71 (2):366—75.Tacastacas J.D., Bray J., Cohen Y.K. et al. Update on primary mucosal melanoma. J Am Acad Dermatol 2014;71 (2):366—75.2. Creasman W.T., Phillips J.L., Menck H.R. A survey of hospital management practices for vulvar melanoma. J Am Coll Surg 1999;188:670-5.Creasman W.T., Phillips J.L., Menck H.R. A survey of hospital management practices for vulvar melanoma. J Am Coll Surg 1999;188:670-5.3. Stang A., Streller B., Eisinger B. et al. Population-based incidence rates of malignant melanoma of the vulva in Germany. Gynecol Oncol 2005;96:216-21.Stang A., Streller B., Eisinger B. et al. Population-based incidence rates of malignant melanoma of the vulva in Germany. Gynecol Oncol 2005;96:216-21.4. Chang A.E., Karnell L.H., Menck H.R. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664-78.Chang A.E., Karnell L.H., Menck H.R. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664-78.5. Vyas R., Thompson C., Zargar H. et al. Epidemiology of genitourinary melanoma in the United States: 1992 through 2012. J Am Acad Dermatol 2016;75 (1):144—50.Vyas R., Thompson C., Zargar H. et al. Epidemiology of genitourinary melanoma in the United States: 1992 through 2012. J Am Acad Dermatol 2016;75 (1):144—50.6. Hu D.N., Yu G.P., McCormick S.A. Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. Melanoma Res 2010;20:153-8.Hu D.N., Yu G.P., McCormick S.A. Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. Melanoma Res 2010;20:153-8.7. Stang A., Streller B., Eisinger B. et al. Population-based incidence rates of malignant melanoma of the vulva in Germany. Gynecol Oncol 2005;96:216-21.Stang A., Streller B., Eisinger B. et al. Population-based incidence rates of malignant melanoma of the vulva in Germany. Gynecol Oncol 2005;96:216-21.8. Sugiyama V.E., Chan J.K., Shin J.Y. et al. Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol 2007:110:296-301.Sugiyama V.E., Chan J.K., Shin J.Y. et al. Vulvar melanoma: a multivariable analysis of 644 patients. Obstet Gynecol 2007:110:296-301.9. Aulmann S., Sinn H.P., Penzel R. et al. Comparison of molecular abnormalities in vulvar and vaginal melanomas. Mod Pathol 2014:27:1386-93.Aulmann S., Sinn H.P., Penzel R. et al. Comparison of molecular abnormalities in vulvar and vaginal melanomas. Mod Pathol 2014:27:1386-93.10. Ragnarsson-Olding B., Johansson H., Rutqvist L.E. et al. Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long-term survival among 245 consecutive cases in Sweden 1960-1984. Cancer 1993;71:1893-7.Ragnarsson-Olding B., Johansson H., Rutqvist L.E. et al. Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long-term survival among 245 consecutive cases in Sweden 1960-1984. Cancer 1993;71:1893-7.11. Gökaslan H., Sişmanoğlu A., Pekin T. et al. Primary malignant melanoma of the vagina: a case report and review of the current treatment options. Eur J Obstet Gynecol Reprod Biol 2005;121:243-8.Gökaslan H., Sişmanoğlu A., Pekin T. et al. Primary malignant melanoma of the vagina: a case report and review of the current treatment options. Eur J Obstet Gynecol Reprod Biol 2005;121:243-8.12. Kalampokas E., Kalampokas T., Damaskos C. Primary vaginal melanoma, a rare and aggressive entity. A case report and review of the literature. In Vivo 2017:31:133-9.Kalampokas E., Kalampokas T., Damaskos C. Primary vaginal melanoma, a rare and aggressive entity. A case report and review of the literature. In Vivo 2017:31:133-9.13. Frumovitz M., Etchepareborda M., Sun C.C. et al. Primary malignant melanoma of the vagina. Obstet Gynecol 2010;116:1358-65.Frumovitz M., Etchepareborda M., Sun C.C. et al. Primary malignant melanoma of the vagina. Obstet Gynecol 2010;116:1358-65.14. Pusceddu S., Bajetta E., Carcangiu M.L. et al. A literature overview of primary cervical malignant melanoma: an exceedingly rare cancer. Crit Rev Oncol Hematol 2012;81:185-95.Pusceddu S., Bajetta E., Carcangiu M.L. et al. A literature overview of primary cervical malignant melanoma: an exceedingly rare cancer. Crit Rev Oncol Hematol 2012;81:185-95.15. Bishop K.D., Olszewski A.J. Epidemiology and survival outcomes of ocular and mucosal melanomas: a population-based analysis. Int J Cancer 2014;134:2961-71.Bishop K.D., Olszewski A.J. Epidemiology and survival outcomes of ocular and mucosal melanomas: a population-based analysis. Int J Cancer 2014;134:2961-71.16. Pleunis N., Schuurman M.S., Van Rossum M.M. et al. Rare vulvar malignancies; incidence, treatment and survival in the Netherlands. Gynecol Oncol 2016;142:440-5.Pleunis N., Schuurman M.S., Van Rossum M.M. et al. Rare vulvar malignancies; incidence, treatment and survival in the Netherlands. Gynecol Oncol 2016;142:440-5.17. Verschraegen C.F., Benjapibal M., Supakarapongkul W. et al. Vulvar melanoma at the M.D. Anderson Cancer center: 25 years later. Int J Gynecol Cancer 2011;11:359-64.Verschraegen C.F., Benjapibal M., Supakarapongkul W. et al. Vulvar melanoma at the M.D. Anderson Cancer center: 25 years later. Int J Gynecol Cancer 2011;11:359-64.18. Seifried S., Haydu L.E., Quinn M.J. et al. Melanoma of the vulva and vagina: principles of staging and their relevance to management based on a clinicopatho-logic analysis of 85 cases. Ann Surg Oncol 2015;22:1959-66.Seifried S., Haydu L.E., Quinn M.J. et al. Melanoma of the vulva and vagina: principles of staging and their relevance to management based on a clinicopatho-logic analysis of 85 cases. Ann Surg Oncol 2015;22:1959-66.19. Look K. Y., Roth L.M., Sutton G.P. Vulvar melanoma reconsidered. Cancer 1993;72:143-6.Look K. Y., Roth L.M., Sutton G.P. Vulvar melanoma reconsidered. Cancer 1993;72:143-6.20. Trimble E. L., Lewis J.L., Williams L.L. et al. Management of vulvar melanoma. Gynecol Oncol 1992;45:254-25.Trimble E. L., Lewis J.L., Williams L.L. et al. Management of vulvar melanoma. Gynecol Oncol 1992;45:254-25.21. Kirschner A.N., Kidd E.A., Dewees T., Perkins S.M. Treatment approach and outcomes of vaginal melanoma. Cancer 2013;23:1484-9.Kirschner A.N., Kidd E.A., Dewees T., Perkins S.M. Treatment approach and outcomes of vaginal melanoma. Cancer 2013;23:1484-9.22. Huang Q., Huang H., Wan T. et al. Clinical outcome of 31 patients with primary malignant melanoma of the vagina. J Gynecol Oncol 2013;24:330-5.Huang Q., Huang H., Wan T. et al. Clinical outcome of 31 patients with primary malignant melanoma of the vagina. J Gynecol Oncol 2013;24:330-5.23. Buchanan D.J., Schlaerth J., Kurosaki T. Primary vaginal melanoma: thirteenyear disease-free survival after wide local excision and review of recent literature. Am J Obstet Gynecol 1998;178:1177-84.Buchanan D.J., Schlaerth J., Kurosaki T. Primary vaginal melanoma: thirteenyear disease-free survival after wide local excision and review of recent literature. Am J Obstet Gynecol 1998;178:1177-84.24. Clark K.C., Butz W.R., Hapke M.R. Primary malignant melanoma of the uterine cervix: case report with world literature review. Int J Gynecol Pathol 1999;18:265-73.Clark K.C., Butz W.R., Hapke M.R. Primary malignant melanoma of the uterine cervix: case report with world literature review. Int J Gynecol Pathol 1999;18:265-73.25. Cantuaria G., Angioli R., Fernandez-Abril A., Penalver M. Primary malignant melanoma of the uterine cervix: case report and review of the literature. Prim Care Update Ob Gyns 1998;5:159-60.Cantuaria G., Angioli R., Fernandez-Abril A., Penalver M. Primary malignant melanoma of the uterine cervix: case report and review of the literature. Prim Care Update Ob Gyns 1998;5:159-60.26. Rohwedder A., Philips B., Malfetano J. et al. Vulvar malignant melanoma associated with human papillomavirus DNA: report of two cases and review of literature. Am J Dermatopathol 2002;24:230-40.Rohwedder A., Philips B., Malfetano J. et al. Vulvar malignant melanoma associated with human papillomavirus DNA: report of two cases and review of literature. Am J Dermatopathol 2002;24:230-40.27. Omholt K., Grafstrom E., Kanter Lewensohn L. KIT pathway alterations in mucosal melanomas of the vulva and other sites. Clin Cancer Res 2001;17:3933-42.Omholt K., Grafstrom E., Kanter Lewensohn L. KIT pathway alterations in mucosal melanomas of the vulva and other sites. Clin Cancer Res 2001;17:3933-42.28. Aulmann S., Sinn H.P., Penzel R. et al. Comparison of molecular abnormalities in vulvar and vaginal melanomas. Mod Pathol 2014;27:1386-93.Aulmann S., Sinn H.P., Penzel R. et al. Comparison of molecular abnormalities in vulvar and vaginal melanomas. Mod Pathol 2014;27:1386-93.29. Mordel N., Mor-Yosef S., Ben-Baruch N., Anteby S.O. Malignant melanoma of the uterine cervix: case report and review of the literature. Gynecol Oncol 1989;32:375-80.Mordel N., Mor-Yosef S., Ben-Baruch N., Anteby S.O. Malignant melanoma of the uterine cervix: case report and review of the literature. Gynecol Oncol 1989;32:375-80.30. An J., Li B., Wu L. et al. Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res 2009;19:267-70.An J., Li B., Wu L. et al. Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res 2009;19:267-70.31. Noguchi T., Ota N., Mabuchi Y. et al. A case of malignant melanoma of the uterine cervix with disseminated metastases throughout the vaginal wall. Case Rep Obstet Gynecol 2017: (2017):5656340.Noguchi T., Ota N., Mabuchi Y. et al. A case of malignant melanoma of the uterine cervix with disseminated metastases throughout the vaginal wall. Case Rep Obstet Gynecol 2017: (2017):5656340.32. Norris H.J., Taylor H.B. Melanomas of the vagina. Am J Clin Pathol 1966;46:420-6.Norris H.J., Taylor H.B. Melanomas of the vagina. Am J Clin Pathol 1966;46:420-6.33. Gleason B.G., Hirsch M.N., Nucci M.R. et al. Atypical genital nevi. A clinicopathologic analysis of 56 cases. Am J Surg Pathol 2008;32:51-7.Gleason B.G., Hirsch M.N., Nucci M.R. et al. Atypical genital nevi. A clinicopathologic analysis of 56 cases. Am J Surg Pathol 2008;32:51-7.34. Hou J.Y., Baptiste C., Hombalegowda R.B. et al. Vulvar and vaginal melanoma: a unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma. Cancer 2017;123:1333-44.Hou J.Y., Baptiste C., Hombalegowda R.B. et al. Vulvar and vaginal melanoma: a unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma. Cancer 2017;123:1333-44.35. Sugiyama V.E., Chan J.K., Kapp D.S. Management of melanomas of the female genital tract. Curr Opin Oncol 2008;20:565-9.Sugiyama V.E., Chan J.K., Kapp D.S. Management of melanomas of the female genital tract. Curr Opin Oncol 2008;20:565-9.36. Leitao Jr.M.M. Management of vulvar and vaginal melanomas: current and future strategies. Am Soc Clin Oncol Educ Book 2014:e277-81.Leitao Jr.M.M. Management of vulvar and vaginal melanomas: current and future strategies. Am Soc Clin Oncol Educ Book 2014:e277-81.37. Karasawa K., Wakatsuki M., Kato S. et al. Working Group for Gynecological Tumors. Clinical trial of carbon ion radiotherapy for gynecological melanoma. J Radiat Res 2014;55:343-50.Karasawa K., Wakatsuki M., Kato S. et al. Working Group for Gynecological Tumors. Clinical trial of carbon ion radiotherapy for gynecological melanoma. J Radiat Res 2014;55:343-50.38. Leitao Jr.M.M., Cheng X., Hamilton A.L. et al. Gynecologic Cancer Inter Group (GCIG) consensus review for vulvovaginal melanomas. Int J Gynecol Cancer 2014;24 (9 Suppl 3):S117—22.Leitao Jr.M.M., Cheng X., Hamilton A.L. et al. Gynecologic Cancer Inter Group (GCIG) consensus review for vulvovaginal melanomas. Int J Gynecol Cancer 2014;24 (9 Suppl 3):S117—22.39. Janco J.M., Markovic S.N., Weaver A.L. et al. Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. Gynecol Oncol 2013;129:533-7.Janco J.M., Markovic S.N., Weaver A.L. et al. Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. Gynecol Oncol 2013;129:533-7.40. Sinasac S.E., Petrella T.M., Rouzbah-man M. et al. Melanoma of the vulva and vagina: surgical management and outcomes based on a clinicopathologic review of 68 cases. J Obstet Gynaecol Can 2019;41(6):762-71.Sinasac S.E., Petrella T.M., Rouzbah-man M. et al. Melanoma of the vulva and vagina: surgical management and outcomes based on a clinicopathologic review of 68 cases. J Obstet Gynaecol Can 2019;41(6):762-71.41. Gadducci A., Carinelli S., Guerri-eri M.E., Aletti G.D. Melanoma of the lower genital tract: Prognostic factors and treatment modalities. Gynecol Oncol 2018;150(1):180-9.Gadducci A., Carinelli S., Guerri-eri M.E., Aletti G.D. Melanoma of the lower genital tract: Prognostic factors and treatment modalities. Gynecol Oncol 2018;150(1):180-9.42. Danish H.H., Patel K.R., Switchenko J.M. et al. The influence of postoperative lymph node radiation therapy on overall survival of patients with stage III melanoma, a National Cancer Database analysis. Melanoma Res 2016;26:595-603.Danish H.H., Patel K.R., Switchenko J.M. et al. The influence of postoperative lymph node radiation therapy on overall survival of patients with stage III melanoma, a National Cancer Database analysis. Melanoma Res 2016;26:595-603.43. Slingluff C.L., Flaherty K., Posenberg S. A. et al. Cutaneous melanoma. In: Cancer: Principles and practice of oncology. 9th edn. Eds.: V. T. DeVita, T. S. Lawrence, S.A. Rosenberg. Philadelphia: Lippincott Williams & Wilkins, 2011. Pp. 1643-1691.Slingluff C.L., Flaherty K., Posenberg S. A. et al. Cutaneous melanoma. In: Cancer: Principles and practice of oncology. 9th edn. Eds.: V. T. DeVita, T. S. Lawrence, S.A. Rosenberg. Philadelphia: Lippincott Williams & Wilkins, 2011. Pp. 1643-1691.44. Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol 2008;9:973-81.Piura B. Management of primary melanoma of the female urogenital tract. Lancet Oncol 2008;9:973-81.45. Wilson M.A., Schuchter L.M. Chemotherapy for melanoma. Cancer Treat Res 2016;167:209-29.Wilson M.A., Schuchter L.M. Chemotherapy for melanoma. Cancer Treat Res 2016;167:209-29.46. Harting M.S., Kim K.B. Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma. Melanoma Res 2004; 14:517-20.Harting M.S., Kim K.B. Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma. Melanoma Res 2004; 14:517-20.47. Volpe V.O., Klufas D.M., Hegde U. The new paradigm of systemic therapies for metastatic melanoma. J Am Acad Dermatol 2017;77:356-68.Volpe V.O., Klufas D.M., Hegde U. The new paradigm of systemic therapies for metastatic melanoma. J Am Acad Dermatol 2017;77:356-68.48. Chapman P.B., Hauschild A., Robert C. et al. BRIM-3 Study Group, Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.Chapman P.B., Hauschild A., Robert C. et al. BRIM-3 Study Group, Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16.