Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press78210.17650/1994-4098-2020-16-4-91-99GYNECOLOGY. REVIEWSГИНЕКОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИHuman papillomavirus and endometrial cancer (review of literature and meta-analysis)Рак эндометрия и вирус папилломы человека (обзор литературы и метаанализ)https://orcid.org/0000-0001-8815-2786IbragimovaM. К.ИбрагимоваМ. К.
Russian Federation

5 Kooperativnyy St., Tomsk 634009

Марина Константиновна Ибрагимова 

634009 Томск, пер. Кооперативный, 5 

imk1805@yandex.ruKokorinaE. V.КокоринаЕ. В.
Russian Federation

5 Kooperativnyy St., Tomsk 634009

634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0001-7419-4512TsyganovМ. M.ЦыгановМ. М.
Russian Federation

5 Kooperativnyy St., Tomsk 634009

634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0003-3439-8830ChuruksaevaО. N.ЧуруксаеваО. Н.
Russian Federation

5 Kooperativnyy St., Tomsk 634009

634009 Томск, пер. Кооперативный, 5

https://orcid.org/0000-0002-0714-8927LitviakovN. V.ЛитвяковН. В.
Russian Federation

5 Kooperativnyy St., Tomsk 634009

634009 Томск, пер. Кооперативный, 5

Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of SciencesНИИ онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»13122020164919913032021130320212020https://ojrs.abvpress.ru/ojrs/article/view/782

The important role of human papillomavirus (HPV) of high carcinogenic risk in the emergence and development of cervical cancer is undeniable. Approximately 90 % of cases of verified cervical cancer are HPV positive. The level of infection with this virus exceeds that of gonococci, chlamydia and yeast infections. Currently, one of the most discussed issues is the possibility of the association of HPV with the risk of developing malignant neoplasms when localized in organs that are anatomically close to the cervix. One of these localizations is the body of the uterus. It is known that endometrial cancer is based on its pronounced hormone dependence. Nevertheless, many factors are involved in the carcinogenesis of endometrial neoplasms, including genetic and epigenetic disorders, as well as risk factors, which include alimentary, hormonal, hereditary causes. At the same time, a controversial issue is the involvement of HPV in the development of this type of cancer. The data on the presence of HPV in endometrial cancer are extremely contradictory: the researchers claim both the complete absence of the effect of the virus on the development of this type of cancer, and the detection of HPV in 60–80 % of cases of tumors. In this regard, it becomes necessary to systematize the currently available research results on this issue and to conduct a meta-analysis of the association of HPV infection with the risk of endometrial cancer.

Важнейшая роль вируса папилломы человека (ВПЧ) высокого канцерогенного риска в возникновении и развитии цервикального рака неоспорима. Более 90 % случаев верифицированного рака шейки матки являются ВПЧ-положительными. Уровень инфицированности данным вирусом превосходит уровень инфицированности гонококками, хламидиями и дрожжевой инфекцией. В настоящее время одним из самых обсуждаемых вопросов является возможность ассоциации ВПЧ с риском развития злокачественных новообразований при локализации в органах, анатомически близко расположенных к шейке матки. Одной из таких локализаций является тело матки. Известно, что в основе рака эндометрия лежит его выраженная гормонозависимость. Тем не менее в канцерогенез новообразований эндометрия вовлечено множество факторов, включая генетические и эпигенетические нарушения, а также факторы риска, к которым относятся алиментарные, гормональные, наследственные причины. При этом спорным вопросом является причастность к развитию данного типа рака инфицированности ВПЧ. Данные по наличию ВПЧ при раке эндометрия крайне противоречивы: исследователи заявляют как о полном отсутствии влияния вируса на развитие данного типа рака, так и об обнаружении ВПЧ в 60–80 % случаев опухолей. В связи с этим возникает необходимость систематизировать имеющиеся на настоящее время результаты исследований относительно данного вопроса и провести метаанализ ассоциации инфицированности ВПЧ с риском развития рака эндометрия.

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