Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press85110.17650/1994-4098-2021-17-2-104-111GYNECOLOGY. CLINICAL CASEГИНЕКОЛОГИЯ. КЛИНИЧЕСКИЙ СЛУЧАЙModern possibilities of using immunotherapy in the treatment of cervical cancerСовременные возможности применения иммунотерапии в лечении рака шейки маткиTarasovaA. V.ТарасоваА. В.
Russian Federation

50 Solnechnaya St., Samara 443031, Russia

Россия, 443031 Самара, ул. Солнечная, 50

https://orcid.org/0000-0003-4944-2507GaninaK. A.ГанинаК. А.
Russian Federation

89 Chapaevskaya St., Samara 443099, Russia

Россия, 443099 Самара, ул. Чапаевская, 89

kristga@mail.ruMeshkovaM. A.МешковаМ. А.
Russian Federation

3 2 nd Botkinsky Proezd, Moscow 125284, Russia

Россия, 125284 Москва, 2‑й Боткинский проезд, 3

SolovyevaYu. V.СоловьеваЮ. В.
Russian Federation

89 Chapaevskaya St., Samara 443099, Russia

Россия, 443099 Самара, ул. Чапаевская, 89

IvanovaE. E.ИвановаЕ. Е.
Russian Federation

89 Chapaevskaya St., Samara 443099, Russia

Россия, 443099 Самара, ул. Чапаевская, 89

AkimovL. N.АкимовЛ. Н.
Russian Federation

Россия, 443099 Самара, ул. Чапаевская, 89

Samara Regional Clinical Oncological DispensaryГБУЗ «Самарский областной клинический онкологический диспансер»Samara State Medical University, Ministry of Health of RussiaФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РоссииP. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaМосковский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России200920211721809202118092021https://ojrs.abvpress.ru/ojrs/article/view/851

Cervical cancer (CC) is the fourth most common cancer in women worldwide. Every year, more than 500,000 women are diagnosed with CC, and the disease leads to more than 300,000 deaths worldwide. Infection with the human papillomavirus is the cause of CC in most cases. The disease is largely preventable through preventive vaccination. Approximately 90 % of CC cases are diagnosed in low-and middle-income countries where there are no organized human papillomavirus screening and vaccination programs. A special group in this disease consists of patients who develop recurrent / metastatic CC. To date, the most promising direction of drug treatment for this pathology is drugs that act on the control points of immunity – the PD-1 receptor / PD-L1 ligand, which are used by the tumor to block the immune system. The article presents a clinical case demonstrating the efficacy of the PD-1 inhibitor pembrolizumab for the treatment of recurrent / metastatic CC.

Рак шейки матки (РШМ) – 4‑й по распространенности рак среди женщин во всем мире. Каждый год более чем у 500 тыс. женщин диагностируется РШМ, и это заболевание становится причиной 300 тыс. смертей во всем мире. Инфицирование вирусом папилломы человека является причиной РШМ в большинстве случаев. Болезнь в значительной степени возможно предотвратить путем проведения профилактической вакцинации. Примерно 90 % случаев РШМ диагностируются в странах с низким и средним уровнем дохода, где отсутствуют организованные программы скрининга и вакцинации против вируса папилломы человека. Особую группу при этом заболевании составляют пациентки, у которых развивается рецидивирующий / метастатический РШМ. На сегодняшний день наиболее перспективным направлением лекарственного лечения при данной патологии являются препараты, действующие на контрольные точки иммунитета – рецептор PD-1 / лиганд PD-L1, которые используются опухолью для блокирования иммунной системы. В статье представлен клинический случай, демонстрирующий эффективность применения ингибитора PD-1 пембролизумаба для лечения рецидивирующего / метастатического РШМ.

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