Tumors of female reproductive systemTumors of female reproductive systemОпухоли женской репродуктивной системы1994-40981999-8627Publishing House ABV Press99610.17650/1994-4098-2022-18-3-52-63MAMMOLOGY. REVIEWSМАММОЛОГИЯ. ОБЗОРНЫЕ СТАТЬИMicroRNA-dependent mechanisms of taxane resistance in breast cancerМикроРНК-зависимые механизмы резистентности клеток рака молочной железы к таксанамhttps://orcid.org/0000-0002-8196-9766ApollonovaV. S.АполлоноваВ. С.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0003-4174-2839SidinaE. I.СидинаЕ. И.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0001-6375-8335TkachenkoE. V.ТкаченкоЕ. В.
Russian Federation

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

https://orcid.org/0000-0001-5334-7292MalekA. V.МалекА. В.
Russian Federation

Anastasiya Valeryevna Malek

68 Leningradskaya St., Pesochnyy Settlement, Saint Petersburg 197758

Анастасия Валерьевна Малек 

197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

anastasia@malek.com.ruN. N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Петрова» Минздрава России0212202218352630212202202122022https://ojrs.abvpress.ru/ojrs/article/view/996

Breast cancer (BC) has a leading position in the statistics of oncological morbidity and mortality among women. Taxan-based polychemotherapy regimens are an essential component of the complex therapy of the BC. However, currently used algorithms of taxan-based regimens application do not always provide with desire effect. It indicates the need to identify new prognostic markers and to develop new approaches to modify response of BC cells to standard therapeutic regimens. MicroRNAs, small RNA molecules regulating protein synthesis, are considered as promising markers and potential modulators of the BC cells sensitivity to taxanes.

The review includes a brief summary of the molecular mechanisms of action of the taxanes and the mechanism BC resistance to the process of microtubules depolymerization, provides with analysis of recent experimental and observational studies of the role of microRNAs in control of these mechanisms, and evaluates prospects for the development of new approaches to predict and to improve the cytostatic effects of taxanes through the analysis and modification of cellular microRNAs.

Рак молочной железы (РМЖ) занимает лидирующие позиции в статистике онкологической заболеваемости и смертности среди женщин. схемы полихимиотерапии, включающие препараты группы таксанов, являются важным компонентом комплексной терапии РМЖ. существующие алгоритмы применения таксансодержащих режимов химиотерапии не всегда обеспечивают желаемый эффект. Это указывает на необходимость поиска новых прогностических факторов и разработки методов модификации ответа клеток РМЖ на стандартные схемы терапии. микроРНК, короткие молекулы РНК, формирующие систему регуляции белкового синтеза, рассматриваются как перспективные маркеры и потенциальные модуляторы чувствительности клеток РМЖ к таксанам.

В обзоре кратко описаны молекулярные механизмы цитостатического эффекта таксанов и механизмы резистентности клеток к нарушению процесса деполимеризации микротрубочек, проведен анализ современных экспериментальных и описательных исследований роли молекул микроРНК в регуляции этих механизмов, дана оценка перспектив разработки методов прогнозирования и оптимизации цитостатического эффекта таксанов на основе анализа или модификации состава внутриклеточных микроРНК.

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