Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus

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  • Authors: Tyulyandina A.S.1,2, Ulrikh E.A.3,4, Kolomiets L.A.5, Krasilnikov S.E.6, Kedrova A.G.7,8, Rumyantsev A.A.1, Raskin G.A.9,10, Nesterova A.I.11,12, Volkonskiy M.V.13, Churuksaeva O.N.5, Goryainova A.Y.14,15, Zhavoronkova V.V.16,17, Dmitriev V.N.18,19, Nazranova S.T.20, Shkradyuk A.V.21, Volkova K.S.22, Arutyunova A.I.23, Kunitskaya S.N.21, Stepura L.V.24, Zolotoreva T.G.22, Shakhnovich E.B.25, Ponomareva E.V.21, Strokova M.A.21, Danilova A.S.13, Martynova E.S.26
  • Affiliations:
    1. N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
    2. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
    3. N.N. Petrov National Medical Research Institute of Oncology, Ministry of Health of Russia
    4. I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
    5. Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
    6. Institute of Oncology and Neurosurgery, E.N. Meshalkin National Medical Research Center, Ministry of Health of Russia
    7. Department of Oncology, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation
    8. Department of Obstetrics and Gynecology, Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation
    9. Saint Petersburg State University
    10. Medical and Diagnostic Center of S. Berezin International Institute of Biological Systems
    11. Republican Clinical Oncology Dispensary, Ministry of Health of the Republic of Tatarstan
    12. Kazan Federal University
    13. Moscow City Oncology Hospital No. 62, Moscow Healthcare Department
    14. Clinical Oncology Dispensary No. 1
    15. Kuban State Medical University
    16. Volgograd Regional Clinical Oncology Dispensary
    17. Volgograd State Medical University, Ministry of Health of Russia
    18. Belgorod National Research University
    19. Belgorod Oncology Dispensary
    20. Oncology Dispensary, Ministry of Health of Kabardino-Balkar Republic
    21. V.M. Efetov Crimean Republican Oncology Clinical Dispensary
    22. Samara Regional Clinical Oncology Dispensary
    23. Pyatigorsk Regional Oncology Dispensary
    24. Oncology Dispensary in Shakhty
    25. Korolev City Hospital
    26. A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
  • Issue: Vol 18, No 4 (2022)
  • Pages: 138-146
  • Section: GYNECOLOGY. REVIEWS
  • Published: 01.12.2022
  • URL: https://ojrs.abvpress.ru/ojrs/article/view/1039
  • DOI: https://doi.org/10.17650/1994-4098-2022-18-4-138-146
  • ID: 1039

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Abstract

Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to identify patients at high risk of Lynch syndrome, evaluate the disease prognosis, and estimate the efficacy of immune checkpoint inhibitors and their combinations. This review details current concepts of MSI diagnostics and discusses its predictive value in patients with endometrial cancer. It also describes a new diagnostic algorithm for the detection of dMMR and MSI.

About the authors

A. S. Tyulyandina

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: atjulandina@mail.ru
ORCID iD: 0000-0002-6104-7473

Alexandra S. Tyulyandina.

23 Kashirskoe Shosse, Moscow 115478; 8/2 Trubetskaya St., Moscow 119991

Russian Federation

E. A. Ulrikh

N.N. Petrov National Medical Research Institute of Oncology, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-2701-8812

68 Leningradskaya St., Pesochniy Settlement, Saint Petersburg 197758; 41 Kirochnaya St., Saint Petersburg 191015

Russian Federation

L. A. Kolomiets

Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences

ORCID iD: 0000-0002-6854-8940

5 Kooperativnyy Pereulok, Tomsk 634009

Russian Federation

S. E. Krasilnikov

Institute of Oncology and Neurosurgery, E.N. Meshalkin National Medical Research Center, Ministry of Health of Russia

15 Rechkunovskaya St., Novosibirsk 630055

Russian Federation

A. G. Kedrova

Department of Oncology, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation; Department of Obstetrics and Gynecology, Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation

ORCID iD: 0000-0003-1031-9376

28 Orekhovyy Bulvar, Moscow 115682; 91 Volokolamskoe Shosse, Moscow 125371

Russian Federation

A. A. Rumyantsev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-4443-9974

23 Kashirskoe Shosse, Moscow 115478

Russian Federation

G. A. Raskin

Saint Petersburg State University; Medical and Diagnostic Center of S. Berezin International Institute of Biological Systems

ORCID iD: 0000-0002-7522-6552

7-9 Universitetskaya Naberezhnaya, Saint Petersburg 199034; 43 Karla Marksa St., Pesochnyy, Saint Petersburg 197758

Russian Federation

A. I. Nesterova

Republican Clinical Oncology Dispensary, Ministry of Health of the Republic of Tatarstan; Kazan Federal University

ORCID iD: 0000-0002-4880-4353

29 Sibirskiy Trakt, Kazan 420029; 18 Kremlevskaya St., Kazan 420008

Russian Federation

M. V. Volkonskiy

Moscow City Oncology Hospital No. 62, Moscow Healthcare Department

ORCID iD: 0000-0003-4060-5015

6 Staropetrovskiy Proezd, Moscow 125130

Russian Federation

O. N. Churuksaeva

Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences

ORCID iD: 0000-0003-3439-8830

5 Kooperativnyy Pereulok, Tomsk 634009

Russian Federation

A. Yu. Goryainova

Clinical Oncology Dispensary No. 1; Kuban State Medical University

ORCID iD: 0000-0001-7127-7945

146 Dimitrova St., Krasnodar 350040; 4 Mitrofana Sedina St., Krasnodar 350063

Russian Federation

V. V. Zhavoronkova

Volgograd Regional Clinical Oncology Dispensary; Volgograd State Medical University, Ministry of Health of Russia

ORCID iD: 0000-0002-3403-7931

78 Zemlyachki St., Volgograd 400138; 12 Ploschad Pavshykh Bortsov, Volgograd 400131

Russian Federation

V. N. Dmitriev

Belgorod National Research University; Belgorod Oncology Dispensary

ORCID iD: 0000-0002-5523-5718

85 Pobedy St., Belgorod 308015; 1 Kuybysheva St., Belgorod 308010

Russian Federation

S. T. Nazranova

Oncology Dispensary, Ministry of Health of Kabardino-Balkar Republic

23 Lermontova St., Nalchik 360051

Russian Federation

A. V. Shkradyuk

V.M. Efetov Crimean Republican Oncology Clinical Dispensary

49a Bespalova St., Simferopol 295023

Russian Federation

K. S. Volkova

Samara Regional Clinical Oncology Dispensary

50 Solnechnaya St., Samara 443031

Russian Federation

A. I. Arutyunova

Pyatigorsk Regional Oncology Dispensary

31 Prospekt Kalinina, Pyatigorsk 357502

Russian Federation

S. N. Kunitskaya

V.M. Efetov Crimean Republican Oncology Clinical Dispensary

49a Bespalova St., Simferopol 295023

Russian Federation

L. V. Stepura

Oncology Dispensary in Shakhty

ORCID iD: 0000-0002-1008-6085

153 Shevchenko St., Shakhty 346500

Russian Federation

T. G. Zolotoreva

Samara Regional Clinical Oncology Dispensary

50 Solnechnaya St., Samara 443031

Russian Federation

E. B. Shakhnovich

Korolev City Hospital

24 Tsiolkovskogo St., Korolev 141070

Russian Federation

E. V. Ponomareva

V.M. Efetov Crimean Republican Oncology Clinical Dispensary

49a Bespalova St., Simferopol 295023

Russian Federation

M. A. Strokova

V.M. Efetov Crimean Republican Oncology Clinical Dispensary

49a Bespalova St., Simferopol 295023

Russian Federation

A. S. Danilova

Moscow City Oncology Hospital No. 62, Moscow Healthcare Department

6 Staropetrovskiy Proezd, Moscow 125130

Russian Federation

E. S. Martynova

A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary

16 1-ya Smolenskaya St., Krasnoyarsk 660133

Russian Federation

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