The role of platinum-based antineoplastic drugs and their impact on complete pathological response and prognosis in patients with BRCA-associated triple-negative breast cancer after neoadjuvant treatment: a single institution experience

D. A. Enaldieva; Еналдиева Д. А.; P. V. Krivorotko; Криворотько П. В.; E. N. Imyanitov; Имянитов Е. Н.; E. K. Zhiltsova; Жильцова Е. К.; R. V. Donskikh; Донских Р. В.; A. P. Sokolenko; Cоколенко А. П.; L. F. Shaykhelislamova; Шайхелисламова Л. Ф.; T. T. Tabagua; Табагуа Т. Т.; L. P. Gigolaeva; Гиголаева Л. П.; A. V. Komyakhov; Комяхов А. В.; K. S. Nikolaev; Николаев К. С.; K. Yu. Zernov; Зернов К. Ю.; S. S. Ereshchenko; Ерещенко С. С.; R. M. Paltuev; Палтуев Р. М.; A. A. Bessonov; Бессонов А. А.; A. S. Artemyeva; Артемьева А. С.; R. S. Pesotskiy; Песоцкий Р. С.; N. S. Amirov; Амиров Н. С.; A. S. Emelyanov; Емельянов А. С.; V. V. Mortada; Мортада В. В.; Ya. I. Bondarchuk; Бондарчук Я. И.; V. V. Semiglazov; Семиглазов В. В.; T. Yu. Semiglazova; Семиглазова Т. Ю.; V. F. Semiglazov; Семиглазов В. Ф.; A. M. Belyaev; Беляев А. М.

doi:10.17650/1994-4098-2023-19-1-48-55

The role of platinum-based antineoplastic drugs and their impact on complete pathological response and prognosis in patients with BRCA-associated triple-negative breast cancer after neoadjuvant treatment: a single institution experience

Authors: Enaldieva D.A.¹, Krivorotko P.V.¹, Imyanitov E.N.¹^,2, Zhiltsova E.K.¹, Donskikh R.V.¹, Sokolenko A.P.¹^,2, Shaykhelislamova L.F.¹, Tabagua T.T.¹, Gigolaeva L.P.¹, Komyakhov A.V.¹, Nikolaev K.S.¹, Zernov K.Y.¹, Ereshchenko S.S.¹, Paltuev R.M.¹, Bessonov A.A.³, Artemyeva A.S.¹, Pesotskiy R.S.¹, Amirov N.S.¹, Emelyanov A.S.¹, Mortada V.V.¹, Bondarchuk Y.I.¹, Semiglazov V.V.¹^,4, Semiglazova T.Y.¹, Semiglazov V.F.¹, Belyaev A.M.¹^,5
Affiliations:
1. N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia
2. Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
3. Leningrad Regional Clinical Oncological Dispensary named after L. D. Roman
4. I. P. Pavlov First Saint Petersburg State Medical University
5. I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Issue: Vol 19, No 1 (2023)
Pages: 48-55
Section: MAMMOLOGY. ORIGINAL REPORTS
Published: 25.06.2023
URL: https://ojrs.abvpress.ru/ojrs/article/view/1076
DOI: https://doi.org/10.17650/1994-4098-2023-19-1-48-55
ID: 1076

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

Background. BRCA-associated triple negative breast cancer (TNBC) is considered one of the most aggressive subtypes of breast cancer with high sensitivity to chemotherapy, which leads to increased interest in finding new treatment options for patients with this subtype of breast cancer.

Aim. To determine the role of adding a platinum drug to standard systemic neoadjuvant therapy (NAC) for patients with primary BRCA-associated TNBC with clinical stage T1–3N0–3M0, and to evaluate the effect of platinum-based drugs on recurrence-free survival in patients of this category.

Materials and methods. The study included 75 patients diagnosed with primary BRCA-associated TNBC. They were divided into 2 groups depending on the NAC provided, and then they were subdivided depending on the completion of the course of ongoing NAC, the final pathomorphological result and the presence of recurrence.

Results. Group I included 48 (64 %) patients who received the AC–T regimen; in group II (n = 27 (36 %)) patients received NAC according to the AC–TCarb regimen. Patients of group II showed a higher frequency of achieving pathological complete response (pCR) compared with patients of group I (73.7 % versus 41.2 %, respectively, p = 0.0433). Taking into account the NAC regimens being carried out, patients of group I had a slightly higher risk of recurrence compared to patients of group II (p = 0.099).

Conclusion. In patients with primary BRCA-associated TNBC, the addition of platinum compounds to the systemic NAC resulted in achieving of pCR in 73.7 % cases compared with 41.2 % pCR after the standard anthracycline-taxane NAC, which entails a reduced risk recurrence in this category of patients. Performing a full course of planned NAC has a positive trend in achieving pCR in patients of this category.

Keywords

BRCA1 / 2 mutation, triple-negative breast cancer, breast cancer recurrence, platinum preparations, complete pathomorphological regression, neoadjuvant chemotherapy

About the authors

D. A. Enaldieva

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: dianaenaldieva932@gmail.com
ORCID iD: 0000-0002-2773-3111

Diana Arturovna Enaldieva

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

P. V. Krivorotko

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-4898-9159

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

E. N. Imyanitov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

ORCID iD: 0000-0003-4529-7891

197758

68 Leningradskaya St.

194100

2 Litovskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

E. K. Zhiltsova

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-2029-4582

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

R. V. Donskikh

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-9391-5327

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

A. P. Sokolenko

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia; Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia

ORCID iD: 0000-0001-6304-1609

197758

68 Leningradskaya St.

194100

2 Litovskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

L. F. Shaykhelislamova

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0001-9623-3877

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

T. T. Tabagua

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-1471-9473

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

L. P. Gigolaeva

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0001-7654-4336

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

A. V. Komyakhov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-6598-1669

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

K. S. Nikolaev

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-3377-6369

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

K. Yu. Zernov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-2138-3982

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

S. S. Ereshchenko

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-5090-7001

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

R. M. Paltuev

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-0871-9453

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

A. A. Bessonov

Leningrad Regional Clinical Oncological Dispensary named after L. D. Roman

ORCID iD: 0000-0002-6649-7641

191014

37–39 Liteinyy prospect

Saint Petersburg

Russian Federation

A. S. Artemyeva

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-2948-397X

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

R. S. Pesotskiy

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-2573-2211

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

N. S. Amirov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-2421-3284

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

A. S. Emelyanov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-0528-9937

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

V. V. Mortada

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-1982-5710

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

Ya. I. Bondarchuk

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-6442-0106

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

V. V. Semiglazov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia; I. P. Pavlov First Saint Petersburg State Medical University

ORCID iD: 0000-0002-8825-5221

197758

68 Leningradskaya St.

197022

6–8 Lva Tolstogo St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

T. Yu. Semiglazova

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0002-4305-6691

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

V. F. Semiglazov

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia

ORCID iD: 0000-0003-0077-9619

197758

68 Leningradskaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

A. M. Belyaev

N. N. Petrov Research Institute of Oncology, Ministry of Health of Russia; I. I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

ORCID iD: 0000-0001-5580-4821

197758

68 Leningradskaya St.

191015

41 Kirochnaya St.

Pesochnyy Settlement

Saint Petersburg

Russian Federation

References

Supplementary files

Supplementary Files

Action

1. JATS XML

Download

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register